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Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Sung, Hyun Hwan,Jeon, Hwang Gyun,Jeong, Byong Chang,Seo, Seong Il,Jeon, Seong Soo,Lee, Hyun Moo,Choi, Han-Yong,Kwon, Ghee-Young,Park, Woong Yang,Lee, Jeeyun Neoplasia Press 2017 Translational oncology Vol.10 No.3
<P><I>PURPOSE:</I> Although targeting angiogenesis with tyrosine kinase inhibitors (TKIs) has become standard of care in the treatment of clear cell renal cell carcinoma (RCC), resistance mechanism are not fully understood, and there is a need to develop new therapeutic options overcoming them. <I>METHODS AND MATERIALS:</I> To develop a preclinical model that predicts clinical activity of novel agents in 19 RCC patients, we established patient-derived cell (PDC) and xenograft (PDX) models derived from malignant effusions or surgical specimen. RESULTS: Successful PDCs, defined as cells that maintained growth following two passages, were established in 5 of 15 malignant effusions and 1 of 4 surgical specimens. One PDC, clinically refractory to TKIs, was implanted and engrafted in mice, resulting in a comparable histology to the primary tumor. The PDC-PDX model also showed similar genomic features when tested using targeted sequencing of cancer-related genes. When we examined the drug effects of the PDX model, the tumor cells showed resistance to TKIs and everolimus <I>in vitro</I>. <I>CONCLUSION:</I> The results suggest that the PDC-PDX preclinical model we developed using malignant effusions can be a useful preclinical model to interrogate sensitivity to targeted agents based on genomic alterations.</P>
( Sung Hwan Sohn ),( Sung Jeen Jang ),( Jae Moung Kim ) 한국인터넷정보학회 2010 KSII Transactions on Internet and Information Syst Vol.4 No.4
Cognitive Radio is an advanced enabling technology for the efficient utilization of vacant spectrum due to its ability to sense the spectrum environment. It is important to determine accurate spectrum utilization of the primary system in a cognitive radio environment. In order to define the spectrum utilization state, many CR systems use what is known as the quiet period (QP) method. However, even when using a QP, interference can occur. This causes reduced system throughput and contrary to the basic condition of cognitive radio. In order to reduce the interference time, a frequency-hopping algorithm is proposed here. Additionally, to complement the loss of throughput in the FH, a HMM-based channel prediction algorithm and a channel allocation algorithm is proposed. Simulations were conducted while varying several parameters. The findings show that the proposed algorithm outperforms conventional channel allocation algorithms.
Jang, Kyu Yeon,Ahn, Sang Jung,Kwon, Ji-Hwan,Nam, Ki Min,Kim, Young Heon American Chemical Society 2019 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.123 No.16
<P>The phase transformation from a metastable wurtzite (WZ) CoO to stable rock-salt (RS) CoO nanocrystals via an intermediate spinel (SP) Co<SUB>3</SUB>O<SUB>4</SUB> was examined based on in situ transmission electron microscopy (TEM). Specifically, the atomic evolution during the phase transformation was monitored using high-resolution TEM images of individual nanocrystals. A two-step phase transformation was identified during the heating experiment: rapid oxidation of WZ CoO to SP Co<SUB>3</SUB>O<SUB>4</SUB> and reduction of SP Co<SUB>3</SUB>O<SUB>4</SUB> to RS CoO. In a low temperature range from 200 to 280 °C, the oxidation reaction, which was the first phase transformation from WZ CoO to SP Co<SUB>3</SUB>O<SUB>4</SUB>, occurred spontaneously via remnant oxygen in the TEM column. On the other hand, the reduction reaction, which was the second phase transformation from SP Co<SUB>3</SUB>O<SUB>4</SUB> to RS CoO at high temperatures of over 280 °C, occurred under a low oxygen partial pressure. The phase transformation phenomena were analyzed from thermodynamical and microstructural viewpoints.</P> [FIG OMISSION]</BR>
Jang, Jun Tae,Ko, Daehyun,Ahn, Geumho,Yu, Hye Ri,Jung, Haesun,Kim, Yeon Soo,Yoon, Chansoo,Lee, Sangik,Park, Bae Ho,Choi, Sung-Jin,Kim, Dong Myong,Kim, Dae Hwan Elsevier 2018 Solid-state electronics Vol.140 No.-
<P><B>Abstract</B></P> <P>We report the effect of the oxygen content of the LaAlO<SUB>3</SUB> layer on the synaptic behavior in the Pt/LaAlO<SUB>3</SUB>/Nb-doped SrTiO<SUB>3</SUB> memristor for neuromorphic applications. As the oxygen-content decreases, the current becomes larger and the spike time-dependent plasticity (STDP) becomes less sensitive to the time difference between pre- and post-synaptic spike voltage. In addition, the conduction mechanism, which was found to be a combination of thermionic and Poole-Frenkel emissions, and the effect of oxygen content are explained in association with the oxygen vacancy in the LaAlO<SUB>3</SUB> layer. The trade-off between large current and efficient STDP can be controlled by the oxygen content. Furthermore, the results of extracting the synaptic strength-based model parameters indicate that the Pt/LaAlO<SUB>3</SUB>/Nb-doped SrTiO<SUB>3</SUB> shows the efficient STDP characteristics in comparison to previously reported memristor materials.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Spike time-dependent plasticity (STDP) in the Pt/LaAlO<SUB>3</SUB>/Nb-doped SrTiO<SUB>3</SUB> memristor. </LI> <LI> The effect of oxygen content in the LaAlO<SUB>3</SUB> layer on synaptic behavior. </LI> <LI> The trade-off between large current and efficient STDP controlled by oxygen content. </LI> </UL> </P>
Jang, Guehwan,Won, Hokeun,Lee, Dong-Uk,Noh, Yun-Hee,Lee, Seung-Chul,Choi, Hwan-Won,Yoon, In-Joong,Lee, Yoo Jin,Sang Yoo, Han,Lee, Changhee Elsevier 2019 Veterinary microbiology Vol.231 No.-
<P><B>Abstract</B></P> <P>We have previously reported the generation of the attenuated KNU-141112-S DEL5/ORF3 virus by continuous propagation of highly virulent G2b porcine epidemic diarrhea virus (PEDV) in Vero cells. The present study aimed to assess the safety of S DEL5/ORF3 and to evaluate its effectiveness as a live vaccine for prime-booster vaccinations. Reversion to virulence experiments revealed that the S DEL5/ORF3 strain retains its attenuated phenotype and genetic stability after five successive passages in susceptible piglets. Pregnant sows were primed orally with an S DEL5/ORF3 live vaccine and boosted intramuscularly twice with a commercial killed vaccine at 2-week intervals prior to parturition. This sow vaccination regimen completely protected nursing piglets against virulent G2b challenge, as evidenced by the increase in survival rate from 0% to 100% and the significant reduction in diarrhea intensity, including the amount and duration of PEDV fecal shedding. In addition, despite a 2–3 day period of weight loss in piglets from vaccinated sows after challenge, their daily weight gain was recovered at 7 days post-challenge and became similar to that of unchallenged pigs from unvaccinated sows over the course of the experiment. Furthermore, strong antibody responses to PEDV were verified in the sera and colostrum of immunized sows with the prime-boost treatment and their offspring. Altogether, our data demonstrated that the attenuated S DEL5/ORF3 strain guarantees the safety to host animals with no reversion to virulence and is suitable as an effective primary live vaccine providing durable maternal lactogenic immunity for passive piglet protection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Attenuated G2b PEDV strain S DEL5/ORF3 was pioneered to develop an MLV vaccine. </LI> <LI> S DEL5/ORF3 did not revert to virulence after successive back passages in piglets. </LI> <LI> Prime-boost maternal vaccinations conferred complete protection against PEDV. </LI> <LI> Robust humoral immunity was observed in the sera and colostrum of vaccinated dams. </LI> <LI> Sufficient lactogenic immunity provides passive protection in suckling neonates. </LI> </UL> </P>