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Jang, Hye-Ock,Lee, Chang,Choi, Min-Gak,Shin, Sang-Hun,Chung, In-Kyo,Yun, Il The Korean Society of Pharmacology 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.3
To elucidate the molecular mechanism of pharmacological action of local anesthetics, we studied membrane actions of tetracaine, bupivacaine, lidocaine, prilocaine and procaine. Fluorescence polarization of n-(9-anthroyloxy)stearic acid (n-AS) was used to examine the effects of these local anesthetics on differential rotational mobility of different positions of the number of synaptosomal plasma membrane vesicle (SPMV) phospholipid carbon atoms. The four membrane components differed with respect to 3, 6, 9 and 16-(9-anthroyloxy)stearic acid (3-AS, 6-AS, 9-AS and 16-AP) probes, indicating that differences in the membrane fluidity might be present. Degrees of the rotational mobility of 3-AS, 6-AS, 9-AS and 16-AP were different depending on depth of hydrocarbon interior. In a dose-dependentmanner, tetracaine, bupivacaine, lidocaine, prilocaine and procaine decreased anisotropy of 3-AS, 6-AS, 9-AS and 16-AP in the hydrocarbon interior of the SPMV. These results indicate that local anesthetics have significant disordering effects on hydrocarbon interior of the SPMV, thus affecting the transport of $Na^+$ and $K^+$ in nerve membranes and leading to anesthetic action.
Jang, Hye-Ock,Cha, Seong-Kweon,Lee, Chang,Choi, Min-Gak,Huh, Sung-Ryul,Shin, Sang-Hun,Chung, In-Kyo,Yun, Il The Korean Society of Pharmacology 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.3
The aim of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine the effect of chlorhexidine digluconate on differential rotational mobility of different positions of the number of membrane bilayer phospholipid carbon atoms. The six membrane components differed with respect to 2, 3, 6, 9, 12, and 16-(9-anthroyloxy)stearic acid (2-AS, 3-AS, 6-AS, 9-AS, 12-AS and 16-AP) probes, indicating different membrane fluidity. Chlorhexidine digluconate increased the rate of rotational mobility of hydrocarbon interior of the cultured Porphyromonas gingivalis outer membranes (OPG) in a dose-dependent manner, but decreased the mobility of surface region (membrane interface) of the OPG. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.
Jang, Hye-Ock,Eom, Hyun-Sup,Roh, Sung-Bae,Yun, ll The Korean Society of Pharmacology 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.1
Very little research has been carried out on safflower seed for the prevention and treatment of the bone deficiency diseases, including osteoporosis, which are supported by scientific evidences. In the present study, $3{\mu}l$ of 0.1% dried crude extract or $2{\mu}l$ of 0.1% dried aqueous fraction were shown to significantly accelerate the rate of differentiation of osteoblast. Also, the crude extract and aqueous fraction increased the $[Ca^{2+}]_i$ of the cultured osteoblast cells: $3{\mu}l$ of 0.1% dried crude extract and $2{\mu}l$ of 0.1% dried aqueous fraction significantly increased the $[Ca^{2+}]_i$ of the cultured osteoblast cells ($8{\times}10^{-4}$) to the extent that it deserves a considerable attention. Furthermore, the crude extract and aqueous fraction increased the $[Ca^{2+}]_i$ of the cultured osteoblast cells, and $300{\mu}M$ $Cd^{2+}$, specific calcium channel blocker, completely blocked the increase. Therefore, the increased $[Ca^{2+}]_i$ of the cultured osteoblast cells by safflower seed component continued to activate calcium channel.
( Sang Joun Yu ),( In Chae Na ),( Han Wook Jang ),( Moon Jin Jung ),( Byung Ock Kim ) 조선대학교 치의학연구원 2015 Oral Biology Research (Oral Biol Res) Vol.39 No.1
Purpose: This study examined the width of keratinized gingiva and attached gingiva after an apically repositioned flap (APF group), APF combined with free gingival grafts (FGG group), and APF combined with collagen wound dressing (Collatape® group), both clinically and histomorphometrically. Materials and Methods: The right and left maxillary canine areas of eight mongrel dogs were used (16 surgical sites). In the maxilla, the canine areas were used as experimental sites. Three different surgical techniques were performed on the sixteen canine areas(apically repositioned flap; APF group, APF combined with free gingival grafts; FGG group, and APF combined with collagen wound dressing; Collatape® group). After 6 weeks, clinical and histomorphometric evaluation were done. Results: The FGG group showed more attached gingiva and a more favorable physiological appearance than the other groups. However, there was no significant difference in keratinized gingiva and attached gingiva among the three groups. According to the results of the histomorphometric examination, keratinized gingiva were formed in all groups. The FGG group showed thicker epithelium and connective tissue than the APF group. Collatape® group showed thicker connective tissue than the APF group. Conclusion: The clinical and histomorphometric results suggested that APF combined with collagen wound dressing promotes more favorable healing of the keratinized and attached gingiva.
The Effect of Dibucaine.HCl on the Physical Properties of Neuronal Membranes
Jang, Hye-Ock,Hyun, Cheol-Ho,Yoon, Jin-Hyeok,Kang, Yong-Gyu,Park, Sung-Min,Park, Young-Sik,Park, Jun-Seop,Ok, Jin-Seok,Lee, Dong-Hun,Bae, Moon-Kyung,Yun, Il Korean Society of Photoscience 2005 Journal of Photosciences Vol.12 No.2
Fluorescent probe techniques were used to evaluate the effect of dibucaine.HCl on the physical properties (transbilayer asymmetric lateral mobility, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex. An experimental procedure was used based on selective quenching of 1,3-di(l-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, and radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py. Dibucaine.HCl increased the bulk lateral mobility, and annular lipid fluidity in SPMV lipid bilayers, and had a greater fluidizing effect on the inner monolayer than the outer monolayer. The magnitude of increasing effect on annular lipid fluidity in SPMV lipid bilayer induced by dibucaine.HCl was significantly far greater than magnitude of increasing effect of the drug on the lateral mobility of bulk SPMV lipid bilayer. It also caused membrane proteins to cluster. These effects of dibucaine.HCl on neuronal membranes may be responsible for some, though not all, of the local anesthetic actions of dibucaine.HCl.
Jang, Hye-Ock,Kim, Ji-Suk,Kwon, Woo-Cheol,Kim, Jeong-Kuk,Ko, Myung-Suk,Kim, Dong-Hoo,Kim, Won-Il,Jeon, Young-Chan,Chung, In-Kyo,Shin, Sang-Hun,Chung, Jin,Bae, Moon-Kyung,Yun, Il 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.2
To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). $Pb^{2+}$ inhibited the immediate CRACI dose-dependent manner. Influx of $Pb^{2+}$ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of $Pb^{2+}$ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of $Ca^{2+}$ upon $Ca^{2+}$ readdition, is partially inhibited by $Pb^{2+}$ and (2) the influx of $Pb^{2+}$ was enhanced after CRACI had been induced.
Data Sharing of Web-GIS Based on OWS
Jang, In Sung,Choi, Hae Ock,Lee, Jong Hun 대한원격탐사학회 2001 International Symposium on Remote Sensing Vol.17 No.1
Recently, due to explosive in crease of user's interest and wide spread of the Internet, Internet users usually share geo-spatial object data through the WWW (World Wide Web). Therefore, there must be a standard for accessing, processing, and sharing various heterogeneous geo-spatial abject data without considering formats and locations of them. The objective of this paper is to design and implement a standard method for sharing heterogeneous geo-spatial object data distributed on the Internet. For it, we have adopts international standards and follows OWS(OGC Web Service) based on OGC' WM T(Web Map Testbed). Therefore can share various heterogeneous geo-spatial object data distributed through the Internet.