Gemcitabine And Cisplatin Followed by Chemo-Radiation for Advanced Nasopharyngeal Carcinoma

Jamshed, Arif,Hussain, Raza,Iqbal, Hassan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Concurrent chemo-radiation (CRT) has been established as the standard of care for non-metastatic loco-regionally advanced nasopharyngeal carcinoma (NPC) but recently the addition of induction chemotherapy in the already established regimen has presented an attractive multidisciplinary approach. This retrospective study was carried out to evaluate the efficacy of induction chemotherapy (IC) followed by CRT for the management of loco-regionally advanced NPC. Between July 2005 and September 2010, 99 patients were treated with cisplatin based IC followed by CRT. Induction chemotherapy included a 2 drug combination; intravenous gemcitabine $1000mg/m^2$ on day 1 and 8 and cisplatin $75mg/m^2$ on day 1 only. Radiotherapy (RT) was given as a phase treatment to a total dose of 70 Gy in 35 fractions. Concurrent cisplatin ($75mg/m^2$) was administered to all patients on days 1, 22 and 43. All patients were evaluated for tumor response and adverse effects after IC and 6 weeks after the completion of the treatment protocol. Statistical analysis was performed using SPSS version 17 and Kaplan Meier estimates were applied to project survival. Median follow-up duration was 20 months. The 5-year overall survival (OS), loco regional control (LRC) and relapse free survival (RFS) rates were 71%, 73% and 50%respectively. Acute grade 4 toxicity related to induction chemotherapy and concurrent chemo-radiation was 4% and 2% respectively, with only 3 toxicity-related hospital admissions. We conclude that induction gemcitabine and cisplatin followed by chemo-radiation is a safe and effective regimen in management of nasopharyngeal carcinoma, meriting further investigation in randomized clinical trials.

Revisiting Financial Inclusion and Income Inequality Nexus: Evidences from Selected Economies in Asia

Jamshed ALI,Muhammad Arshad KHAN,Misbah WADOOD,Usman Shaukat KHAN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.12

This study aims to measure financial inclusion and examine its impact on income inequality in a panel of 18 Asian countries over the period 1997–2017. Two alternative approaches for developing financial inclusion index are used: one approach following the methodology of Sarma (2008), while the other is the Dynamic Factor Model (DFM)-based index. The impact of individual indicators and index of financial inclusion on inequality in income is analyzed. The Generalized Method of Moment (GMM) approach is used for empirical analysis. The results indicate that micro-level financial inclusion has a weak negative and statistically significant impact on income inequality. Macro-level index and all individual indicators of financial inclusion do not affect income inequality in the selected sample of economies. The income inequality issues have different natures and cannot be fixed by financial inclusion only. It needs holistic structural reforms to enable fair distribution of income and make an equitable financial system. Financial inclusion is a relatively less important intervention tool regarding fixing the issue of income inequality. This is one of the first studies that used the DFM method for financial inclusion indices construction.

Issues and Misconceptions of Financial Inclusion Indices: Evidences from Selected Asian Economies

Jamshed ALI,Muhammad Arshad KHAN,Usman Shaukat KHAN,Misbah WADOOD 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.12

This study aims to revisit the issues and misconceptions about financial inclusion (FI) indices. For indices construction, this study uses two approaches: one approach following the methodology of Sarma (2008) which is based on UNDP methodology, while the other is the Dynamic Factor Model (DFM)-based index of Stock and Watson (2002) and Rehman et al. (2021). The data of 18 economies of Asia from 1997 till 2017 is used for indices construction and analysis. The authors constructed macro and micro-level financial inclusion indices based on the different types of financial inclusion indicators. Second, the authors have critically evaluated two different approaches, and the results show that Sarma (2008)-based index show financial inclusion’s level, while DFM-based index reveal fluctuation in the current year’s financial inclusion level due to the prior variations. For measuring the level of financial inclusion, the Sarma (2008) index is effective, while for forecasting the level of financial inclusion, the DFM approach is more appropriate. Furthermore, the micro and macro aspects of financial inclusion should be reflected in separate indices for better understanding and in-depth insights.

Trajectory Tracking Control of Multi-DOF Robot without Considering System Dynamics

Saad Jamshed Abbasi,Hamza Khan,이민철 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.9

In this study, two different control logics have been designed for the position control of a robot with five degrees of freedom (DOFs). First, a sliding mode control with a sliding perturbation observer (SMCSPO) has been proposed. The SMCSPO is robust against perturbation, which is the sum of nonlinearities, parametric uncertainties, and external disturbances. To implement the SMCSPO, linear parameters of the system are required; however, these are difficult to identify. Moreover, it is exigent to derive the equation of motion for the multi-DOF robot. Accordingly, an integral sliding mode control (ISMC) has been designed for the position control of this multi-DOF robot. The ISMC controller does not require a mathematical model of the system. The ISMC control input applies a switching gain to compensate for the perturbation and system dynamics. In comparison with the SMCSPO, the ISMC has improved the tracking performance of the system because of its unique characteristics. Both control schemes have been implemented in MATLAB/Simulink. It has been observed that the tracking error of each ISMC joint is lower than that of the SMCSPO.

Reaction Force Estimation of 1 Link Robotic Manipulator Using Robust Control

Saad Jamshed,Karam Dad Kallu,Min-Cheol Lee 제어로봇시스템학회 2018 제어로봇시스템학회 국내학술대회 논문집 Vol.2018 No.5

Investigation of entropy generation rate and its minimization in helical grooved tubes

Shamoon Jamshed,Shafiq R. Qureshi,Aqeel Shah,Ahmad Hussain 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.10

Surface enhancement in heat exchangers has been actively researched, but enhancements have been mainly on the tube side, involving optimization of the geometry. The effect of surface enhancement has been studied in great detail experimentally, but numerical studies are scarce and involve performance comparisons based on the friction factor and Nusselt number. However, true performance can be assessed based on entropy generation minimization. We performed a numerical study on tubes with helical groove formation to assess entropy generation minimization. The tube data were initially validated experimentally and tube performance was then examined via thermal enhancement factors and entropy generation minimization. The Reynolds number was taken as 5000 to 10000 in accordance with an experimental study. All the tubes had an enhancement factor greater than unity, meaning that they were thermally efficient. However, with regard to irreversibility, the tube with the minimum pitch-0.051 m-(GT02) produced the lowest value and hence the minimum entropy generation rate, and thus represented the optimal choice for heat exchangers.

Esterification of acetic and oleic acids within the Amberlyst 15 packed catalytic column

Yousuf Jamal,Jamshed Ali Khan,Afeeq Shahid,O’Neil Boulanger 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2

A packed column system was used to study the esterification of acetic and oleic acids by the macro-porous acidic resin, Amberlyst 15. All reactions were at a constant temperature (75 oC) and catalyst mass (3 g). The impact of column flow rate conditions and the molar fatty acid to ethanol feedstock ratio on ester production is reported. The maximum ester production was noted at a flow rate of 0.25mL/min. The maximum observed ester yield for acetic acid (95.2±0.5%) and oleic acid (43.8±1.3%) was observed at an acid:ethanol molar ratio of 1 : 3 and 1 : 1, respectively. The difference in yield indicates the importance of the fatty acid chain length to the reaction.

Comparison between Early and Late Onset Breast Cancer in Pakistani Women Undergoing Breast Conservative Therapy: is There any Difference?

Bhatti, Abu Bakar Hafeez,Jamshed, Aarif,Khan, Amina,Siddiqui, Neelam,Muzaffar, Nargis,Shah, Mazhar Ali Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: Early onset breast cancer is associated with poor outcomes but variable results have been reported. It is a significant problem in Pakistani women but remains under reported. Breast conservation plays an important role in surgical management of this younger patient group. The objective of this study was to determine the outcome of breast conservative therapy in patients with early onset breast cancer in our population and compare it with their older counterparts. Materials and Methods: A review of patients with invasive breast cancer who underwent breast conservation surgery at Shaukat Khanum Cancer Hospital from 1997 to 2009 was performed. Patients were divided into two groups i.e. Group I age ${\leq}40$ and Group II >40 years. A total of 401 patients with breast cancer were identified in Group I and 405 patients in Group II. Demographics, histopathological findings and receptor status of the two groups were compared. The Chi square test was used for categorical variables. Outcome was assessed on basis of 10 year locoregional recurrence free survival (LRRFS), disease free survival (DFS) and overall survival (OS). For survival analysis Kaplan Meier curves were used and significance was determined using the Log rank test. Cox regression was applied for multivariate analysis. Results: Median follow up was 4.31 (0.1-15.5) years. Median age at presentation was 34.6 years (17-40) and 51.9 years (41-82) for the two groups. Groups were significantly different from each other with respect to grade, receptor status, tumor stage and use of neoadjuvant therapy. No significant difference was present between the two groups for estimated 10 year LRRFS (86% vs 95%) (p=0.1), DFS (70% vs 70%) (p=0.5) and OS (75% vs 63%) (p=0.1). On multivariate analysis, tumor stage was an independent predictor of LRRFS, DFS and OS. Conclusions: Early onset breast cancer is associated with a distinct biology but does not lead to poorer outcomes in our population.

Optimal torso design selection for dual 7-DOF robot arm using von Mises stress and workspace analysis

Hamza Khan,Saad Jamshed Abbasi,이민철 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.9

This paper presents a unique optimal torso design selection technique for the dual seven-degree-of-freedom robot arm. This optimal design enhances the robot endeffector's workspace with less operational stress. The selection procedure incorporates the von Mises stress and robot workspace analysis in different robot-torso mounting configurations. The torso design selection strategy includes the von Mises stress calculation numerically and by using SolidWorks static analysis for robot arm considered as bolted-fixed end cantilever beam. Followed by robot end-effector workspace analysis using inverse kinematics, which determines the maximum area covered by manipulated robot end-effector in 2-dimensional (2D) and 3-dimensional (3D) space. Subsequently, introducing a selection function for torso design. This selection function is calculated based on weighting coefficients (priority given to stress and workspace), von Mises stress, and workspace area. The selection technique concludes that the torso design with upper-arm mounting configuration is optimal for current robot application, i.e., assembly.

Nonlinear response of stiffened triceratops under impact and non-impact waves

Chandrasekaran, Srinivasan,Nassery, Jamshed Techno-Press 2017 Ocean systems engineering Vol.7 No.3

Dynamic response analysis of offshore triceratops with stiffened buoyant legs under impact and non-impact waves is presented. Triceratops is relatively new-generation complaint platform being explored in the recent past for its suitability in ultra-deep waters. Buoyant legs support the deck through ball joints, which partially isolate the deck by not transferring rotation from legs to the deck. Buoyant legs are interconnected using equally spaced stiffeners, inducing more integral action in dispersing the encountered wave loads. Two typical nonlinear waves under very high sea state are used to simulate impact and non-impact waves. Parameters of JONSWAP spectrum are chosen to produce waves with high vertical and horizontal asymmetries. Impact waves are simulated by steep, front asymmetric waves while non-impact waves are simulated using Stokes nonlinear irregular waves. Based on the numerical analyses presented, it is seen that the platform experiences both steady state (springing) and transient response (ringing) of high amplitudes. Response of the deck shows significant reduction in rotational degrees-of-freedom due to isolation offered by ball joints. Weak-asymmetric waves, resulting in non-impact waves cause steady state response. Beat phenomenon is noticed in almost all degrees-of-freedom but values in sway, roll and yaw are considerably low as angle of incidence is zero degrees. Impact waves cause response in higher frequencies; bursting nature of pitch response is a clear manifestation of the effect of impact waves on buoyant legs. Non-impact waves cause response similar to that of a beating phenomenon in all active degrees-of-freedom, which otherwise would not be present under normal loading. Power spectral density plots show energy content of response for a wide bandwidth of frequencies, indicating an alarming behaviour apart from being highly nonlinear. Heave, being one of the stiff degrees-of-freedom is triggered under non-impact waves, which resulted in tether tension variation under non-impact waves as well. Reduced deck response aids functional requirements of triceratops even under impact and non-impact waves. Stiffened group of buoyant legs enable a monolithic behaviour, enhancing stiffness in vertical plane.