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Chandrasekaran, S.,Karunanithi, S. The Korean Society for Computational and Applied M 2015 Journal of applied mathematics & informatics Vol.33 No.1
This paper is concerned with the existence of mild solutions for partial neutral functional integrodifferential equations with infinite delay in Banach spaces. The results are obtained by using resolvent operators and Krasnoselski-Schaefer type fixed point theorem. An example is provided to illustrate the results.
Response of triceratops to impact forces: numerical investigations
Chandrasekaran, Srinivasan,Nagavinothini, R. Techno-Press 2019 Ocean systems engineering Vol.9 No.4
Triceratops is one of the new generations of offshore compliant platforms suitable for ultra-deepwater applications. Apart from environmental loads, the offshore structures are also susceptible to accidental loads. Due to the increase in the risk of collision between ships and offshore platforms, the accurate prediction of structural response under impact loads becomes necessary. This paper presents the numerical investigations of the impact response of the buoyant leg of triceratops usually designed as an orthogonally stiffened cylindrical shell with stringers and ring frames. The impact analysis of buoyant leg with a rectangularly shaped indenter is carried out using ANSYS explicit analysis solver under different impact load cases. The results show that the shell deformation increases with the increase in impact load, and the ring stiffeners hinder the shell damage from spreading in the longitudinal direction. The response of triceratops is then obtained through hydrodynamic response analysis carried out using ANSYS AQWA. From the results, it is observed that the impact load on single buoyant leg causes periodic vibration in the deck in the surge and pitch degrees of freedom. Since the impact response of the structure is highly affected by the geometric and material properties, numerical studies are also carried out by varying the strain rate, and the location of the indenter and the results are discussed.
Mathieu stability of offshore Buoyant Leg Storage & Regasification Platform
Chandrasekaran, S.,Kiran, P.A. Techno-Press 2018 Ocean systems engineering Vol.8 No.3
Increasing demand for large-sized Floating, Storage and Regasification Units (FSRUs) for oil and gas industries led to the development of novel geometric form of Buoyant Leg Storage and Regasification Platform (BLSRP). Six buoyant legs support the deck and are placed symmetric with respect to wave direction. Circular deck is connected to buoyant legs using hinged joints, which restrain transfer of rotation from the legs to deck and vice-versa. Buoyant legs are connected to seabed using taut-moored system with high initial pretension, enabling rigid body motion in vertical plane. Encountered environmental loads induce dynamic tether tension variations, which in turn affect stability of the platform. Postulated failure cases, created by placing eccentric loads at different locations resulted in dynamic tether tension variation; chaotic nature of tension variation is also observed in few cases. A detailed numerical analysis is carried out for BLSRP using Mathieu equation of stability. Increase in the magnitude of eccentric load and its position influences fatigue life of tethers significantly. Fatigue life decreases with the increase in the amplitude of tension variation in tethers. Very low fatigue life of tethers under Mathieu instability proves the severity of instability.
Chandrasekaran, S.,Choi, W.M.,Chung, J.S.,Hur, S.H.,Kim, E.J. North-Holland 2014 Materials Letters Vol.136 No.-
Three dimensional (3D) crumpled reduced graphene oxide (RGO)-Co<SUB>3</SUB>O<SUB>4</SUB> nanohybrids were synthesized via a novel and facile solution method for use in UV-induced hydrogen evolution reaction (HER). The synthesized RGO-Co<SUB>3</SUB>O<SUB>4</SUB> was calcined at a temperature from 300<SUP>o</SUP>C to 500<SUP>o</SUP>C to examine the effect of calcination on its HER activity. The 500<SUP>o</SUP>C-calcined 3D-crumpled RGO-Co<SUB>3</SUB>O<SUB>4</SUB> exhibited the highest photocurrent density under UV illumination due to the improved interfacial hole transfer and suppressed electron recombination. In addition, it also showed excellent durability even after 1000 cycles in acidic solution.
Chandrasekaran, Sundaram,Bowen, Chris,Roscow, James,Zhang, Yan,Dang, Dinh Khoi,Kim, Eui Jung,Misra, R.D.K.,Deng, Libo,Chung, Jin Suk,Hur, Seung Hyun Elsevier 2019 Physics reports Vol.792 No.-
<P><B>Abstract</B></P> <P>This comprehensive review focuses on recent advances in energy harvesting of micro-scale and nano-scale generators based on piezoelectric and triboelectric effects. The development of flexible and hybrid devices for a variety of energy harvesting applications are systematically reviewed. A fundamental understanding of the important parameters that determine the performance of piezoelectric, triboelectric and hybrid devices are summarized. Current research directions being explored and the emerging factors to improve harvester functionality and advance progress in achieving high performance and durable energy conversion are provided. Investigations with regard to integrating flexible matrices and optimizing the composition of the piezoelectric and triboelectric materials are examined to enhance device performance and improve cost-effectiveness for the commercial arena. Finally, future research trends, emerging device structures and novel materials in view of imminent developments and harvesting applications are presented.</P>
Chandrasekaran, Arun Pandian,Suresh, Bharathi,Kim, Hyongbum Henry,Kim, Kye-Seong,Ramakrishna, Suresh AlphaMed Press, Inc. 2017 Stem Cells Vol. No.
<P>Post-translational modification by ubiquitin molecules is a key regulatory process for stem cell fate determination. Ubiquitination and deubiquitination are the major cellular processes used to balance the protein turnover of several transcription factors that regulate stem cell differentiation. Deubiquitinating enzymes (DUBs), which facilitate the processing of ubiquitin, significantly influence stem cell fate choices. Specifically, DUBs play a critical regulatory role during development by directing the production of new specialized cells. This review focuses on the regulatory role of DUBs in various cellular processes, including stem cell pluripotency and differentiation, adult stem cell signaling, cellular reprogramming, spermatogenesis, and oogenesis. Specifically, the identification of interactions of DUBs with core transcription factors has provided new insight into the role of DUBs in regulating stem cell fate determination. Thus, DUBs have emerged as key pharmacologic targets in the search to develop highly specific agents to treat various illnesses.</P>
Chandrasekaran, Murugesan,Subramanian, Dharaneedharan,Yoon, Ee,Kwon, Taehoon,Chun, Se-Chul The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.3
Biological control agents (BCAs) from different microbial taxa are increasingly used to control bacterial wilt caused by Ralstonia solanacearum. However, a quantitative research synthesis has not been conducted on the role of BCAs in disease suppression. Therefore, the present study aimed to meta-analyze the impacts of BCAs on both Ralstonia wilt disease suppression and plant (host) growth promotion. The analysis showed that the extent of disease suppression by BCAs varied widely among studies, with effect size (log response ratio) ranging from -2.84 to 2.13. The disease incidence and severity were significantly decreased on average by 53.7% and 49.3%, respectively. BCAs inoculation also significantly increased fresh and dry weight by 34.4% and 36.1%, respectively on average. Also, BCAs inoculation significantly increased plant yield by 66%. Mean effect sizes for genus Pseudomonas sp. as BCAs were higher than for genus Bacillus spp. Among antagonists tested, P. fluorescens, P. putida, B. cereus, B. subtilis and B. amyloliquefaciens were found to be more effective in general for disease reduction. Across studies, highest disease control was found for P. fluorescens, annual plants, co-inoculation with more than one BCA, soil drench and greenhouse condition were found to be essential in understanding plant responses to R. solanacearum. Our results suggest that more efforts should be devoted to harnessing the potential beneficial effects of these antagonists, not just for plant growth promoting traits but also in mode of applications, BCAs formulations and their field studies should be considered in the future for R. solanacearum wilt disease suppression.
Chandrasekaran Karthikeyan,Kokkarachedu Varaprasad,Sungjun Kim,Ashok Kumar Jangid,Wonjeong Lee,Abdulrahman Syedahamed Haja Hameed,Kyobum Kim 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
The new development of inorganic (IO) nanoparticle (NPs)-based nanomedicines in anticancer therapy isan active area of research. The cellular uptake of IO NPs plays a crucial role in their efficacy as anticanceragents. In this case, IO NPs cellular uptake depends on physical and chemical parameters, including size,shape, and surface modification of the nanoparticles. From the cellular uptake, one of the essentialparameters for small size plays a critical role in the NPs’ due to their ability to passively diffuse acrossthe cell membrane or enter cells through endocytosis. In this study, the inorganic SnO2 (tin dioxide)and SA (sodium alginate) were made into SnO2 (SASnO2) using a simple one-pot green method. Biomedical studies have shown that SASnO2 NPs exhibit greater antibacterial, antioxidant, and anticancerproperties than SnO2 NPs. The prepared SnO2 and SASnO2 NPs were tested against breast cancer cells inanticancer studies. In cellular uptake studies, the smaller size of SASnO2 NPs (19 nm) resulted in highercellular uptake compared to SnO2 NPs (38 nm). The larger surface area of these SASnO2 NPs allows formore contact with biological membranes and internalization (cell uptake) by cancer cells, resulting inenhanced anticancer therapy when using SASnO2 NPs.