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GENERATION Y AND ITS PERCEPTION OF COOL BRANDS : A MIXED-METHOD APPROACH
Ana Jakić,Maximilian Wagner,Anton Meyer 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.10
Generation Y is becoming important to marketers. Since this consumer is disloyal, more value has to be offered to him. This value can be generated through “coolness” of a brand. By means of a mixed-method approach the German Generation Y consumer is characterized and his perception of cool brands elaborated.
GENERATION Y AND ITS PERCEPTION OF COOL BRANDS – A MIXED-METHOD APPROACH
Ana Jaki?,Maximilian Wagner,Anton Meyer 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7
Generation Y is becoming important to marketers. Since this consumer is disloyal, more value has to be offered to him. This value can be generated through “coolness” of a brand. By means of a mixed-method approach the German Generation Y consumer is characterized and his perception of cool brands elaborated.
Cai, Geping,Napolitano, José,G.,McAlpine, James B.,Wang, Yuehong,Jaki, Birgit U.,Suh, Joo-Won,Yang, Seung Hwan,Lee, In-Ae,Franzblau, Scott G.,Pauli, Guido F.,Cho, Sanghyun American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.11
<P>Thirty-five thousand actinomycete extracts were screened for anti-<I>Mycobacterium tuberculosis</I> (<I>M. tb</I>) activity, followed by C<SUB>18</SUB> cartridge fractionation of 37 prioritized extracts. Based on MICs against replicating and nonreplicating <I>M. tb</I>, and IC<SUB>50</SUB> values against Vero cells to generate selectivity indices, seven fractions from seven different strains were selected for further examination. When cultured in G.S.S. media and extracted with ethyl acetate, the <I>Streptomyces hygroscopicus</I> strain ECUM 14046 yielded an extract with promising anti-<I>M. tb</I> activity and a well-defined chromatographic profile. Fractionation by preparative HPLC and subsequent structure elucidation of two active fractions using 1D- and 2D-NMR and MS methods revealed the presence of two cyclohexapeptides, hytramycins V and I, each containing three unusual piperazic acid moieties. The use of <SUP>1</SUP>H iterative full spin analysis (HiFSA) on both hytramycins confirmed that quantum mechanics-simulated spectra match the experimental data, and all <I>J</I><SUB>H,H</SUB> and δ<SUB>H</SUB> values are consistent with the proposed structures. The absolute configuration of each amino acid moiety was determined by Marfey’s method. The MICs against replicating and, more importantly, nonreplicating <I>M. tb</I> fall into the range of some existing second-line anti-TB drugs, such as streptomycin and capreomycin, respectively. The activities were maintained against <I>M. tb</I> strains that represent the major global clades, as well as H<SUB>37</SUB>Rv-isogenic strains that are resistant to individual clinical anti-TB drugs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-11/np400145u/production/images/medium/np-2013-00145u_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400145u'>ACS Electronic Supporting Info</A></P>
Discovery and Characterization of the Tuberculosis Drug Lead Ecumicin
Gao, Wei,Kim, Jin-Yong,Chen, Shao-Nong,Cho, Sang-Hyun,Choi, Jongkeun,Jaki, Birgit U.,Jin, Ying-Yu,Lankin, David C.,Lee, Ji-Ean,Lee, Sun-Young,McAlpine, James B.,Napolitano, José,G.,Franzblau, Sc American Chemical Society 2014 ORGANIC LETTERS Vol.16 No.23
<P>The new tuberculosis (TB) lead ecumicin (<B>1</B>), a cyclic tridecapeptide, was isolated from <I>Nonomuraea sp.</I> MJM5123, following a high-throughput campaign for anti-TB activity. The large molecular weight of 1599 amu detected by LC-HR-MS precluded the initial inference of its molecular formula. The individual building blocks were identified by extensive NMR experiments. The resulting two possible planar structures were distinguished by LC-MS<SUP>2</SUP>. Determination of absolute configuration and unambiguous structural confirmation were carried out by X-ray crystallography and Marfey’s analysis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2014/orlef7.2014.16.issue-23/ol5026603/production/images/medium/ol-2014-026603_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol5026603'>ACS Electronic Supporting Info</A></P>