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RISS 인기검색어
- 검색키워드
- 저자 : Jagdish Chandra (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia
Gunjan Mahajan,Sunita Sharma,Jagdish Chandra,Anita Nangia 대한혈액학회 2017 Blood Research Vol.52 No.3
Background: Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most preva-lent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism. We investigated the role of hepcidin and other conventional iron parameters to assess iron status among children with ACD and IDA. We also identified children with ACD who developed iron deficiency (ID). Methods: The study was undertaken in anemic children with 30 cases each of ACD and IDA along with 30 age and sex-matched controls. The ACD cases were subdivided into pure ACD and ACD with coexistent ID. All cases were subjected to following tests: complete blood count with peripheral smear, serum C-reactive protein, serum interleukin-6, iron studies, serum soluble transferrin receptor (sTfR), and serum hepcidin. Results: The mean serum hepcidin concentration was significantly increased in pure ACD patients (143.85±42.76 ng/mL) as compared to those in IDA patients (6.01±2.83 ng/mL, P<0.001) and controls (24.96±9.09 ng/mL, P<0.001). Also, compared to pure ACD pa-tients [normal sTfR levels (<3 μg/mL)], the serum hepcidin concentration was reduced significantly in ACD patients with ID [high sTfR levels (≥3 μg/mL)] with a mean of 10.0±2.97 ng/mL. Conclusion: Hepcidin measurement can provide a useful tool for differentiating ACD from IDA and also help to identify an iron deficiency in ACD patients. This might aid in the appropriate selection of therapy for these patients.
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Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia
Gunjan Mahajan,Sunita Sharma,Jagdish Chandra,Anita Nangia 대한혈액학회 2017 Blood Research Vol.52 No.3
Background: Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most preva-lent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism. We investigated the role of hepcidin and other conventional iron parameters to assess iron status among children with ACD and IDA. We also identified children with ACD who developed iron deficiency (ID). Methods: The study was undertaken in anemic children with 30 cases each of ACD and IDA along with 30 age and sex-matched controls. The ACD cases were subdivided into pure ACD and ACD with coexistent ID. All cases were subjected to following tests: complete blood count with peripheral smear, serum C-reactive protein, serum interleukin-6, iron studies, serum soluble transferrin receptor (sTfR), and serum hepcidin. Results: The mean serum hepcidin concentration was significantly increased in pure ACD patients (143.85±42.76 ng/mL) as compared to those in IDA patients (6.01±2.83 ng/mL, P<0.001) and controls (24.96±9.09 ng/mL, P<0.001). Also, compared to pure ACD pa-tients [normal sTfR levels (<3 μg/mL)], the serum hepcidin concentration was reduced significantly in ACD patients with ID [high sTfR levels (≥3 μg/mL)] with a mean of 10.0±2.97 ng/mL. Conclusion: Hepcidin measurement can provide a useful tool for differentiating ACD from IDA and also help to identify an iron deficiency in ACD patients. This might aid in the appropriate selection of therapy for these patients.
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Molecular identification of selected bees from the Indian Himalaya: A preliminary effort
Pakrashi Avas,Kundu Shantanu,Saini Jagdish,Tyagi Kaomud,Chandra Kailash,Kumar Vikas 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.4
DNA barcoding has largely been tested for a wide range of taxa and evidenced as a reliable and rapid molecular tool for species-level identification. The present study lends to generate 156 DNA barcodes, of which 141 belonged to 30 morphologically identified bees from the Indian Himalayan Regions (IHRs). The generated barcode data along with 84 sequences of global database distinctly discriminated all the studied species with sufficient genetic distances and cohesive monophyletic clustering in Bayesian analysis (BA) phylogeny. The species delimitation methods, Automatic Barcode Gap Discovery (ABGD), Bayesian Poisson-Tree-Processes (bPTP), and General Mixed Yule-coalescent (GMYC) yielded 68, 70, and 71 molecular operational taxonomic units (MOTUs) respectively. The present DNA barcode-based examination detected the possible cryptic diversity in two Apis species (A. cerana and A. dorsata), Bombus hypnorum, Lepidotrigona arcifera, and Ceratina sutepensis. The present study also evidenced the species complexes within Bombus albopleuralis and Bombus trifasciatus in the IHRs. The species delimitation methods also detected an additional seven putative species from the IHRs, which were identified up to the genus level. In conclusion, this preliminary effort helps to develop a reliable barcode database of bees from the Indian IHRs to facilitate the future systematics study. These molecular data can be utilized to evaluate the population structures and assist to formulate the effective plans for bee conservation.
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