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- 저자 : Jaeseol Park (검색결과 4 건)
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박재설(Jaeseol Park),강연욱(Yeonwook Kang),장은주(Eun Joo Chang),오은아(Euna Oh),유경호(Kyung Ho Yu),이병철(Byuug Chul Lee) 한국언어청각임상학회 2006 Communication Sciences and Disorders Vol.11 No.3
본 연구는 혈관성 치매 환자들(VD)과 알츠하이머형 치매 환자들(DAT)의 단어 유창성을 비교하여 단어 유창성 검사에서 요구되는 인지과정인 군집화와 전환에 두 치매 집단이 어떤 결함을 지니고 있는지를 알아보고자 수행되었다. 치매 집단은 치매의 초기 단계에 속하는 37명의 VD와 44명의 DAT로 구성되었고 66명의 정상 노인(NE)이 통제집단으로 참여하였다. 대상자들에게는 의미(동물)와 음소(ㄱ,ㅇ,ㅅ) 유창성 검사를 실시하였고, 각 검사에서 4개의 점수(정반응 수, 군집 크기, 전환 수 및 오류 수)를 산출하였다. 그 결과, VD와 DAT는 모두 치매의 초기부터 단어 유창성 검사에서 정상노인들보다 현저하게 낮은 수행을 나타내지만 군집화와 전환의 결함 여부 및 결함이 나타나는 시점은 서로 다르다는 사실이 밝혀졌다. 이 결과가 VD와 DAT의 변별에 어떤 함의를 가지는지 논의하였다. The present study was conducted to examine the deficits of clustering and switching processes on the semantic and phonemic fluencies in 57 vascular dementia(VD), 44 Dementia of the Alzheimer’s Type(DAT), and 66 normal elderly(NE). All the patients were in very mild to mild level of dementia (CDR≤1.0). The subjects were given the tests of phonemic(ㄱ, ㅇ, ㅅ) and semantic fluency(animals). The following 4 types of scores were obtained from each test: (a) total number of words generated, excluding errors; (b) mean clustering size; (c) number of switches; and (d) number of errors (repetitions and intrusion). The results found that both VD and DAT, even at the early stages of dementia, showed significantly lower performance on the verbal fluency test than the NE did. The types and timing of deficits in clustering and switching processed between two dementia groups. We discussed their implications on the differentiation between VD and DAT.
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진주희,Jaeseol Park,Soh-Jeong Yang,염지영,Yisuh Ahn,백민재,Hui Jin Ryu,Byung Hwa Lee,Noh Eul Han,Kyung Hi Ryu,강연욱 대한치매학회 2018 Dementia and Neurocognitive Disorders Vol.17 No.1
Background and Purpose: Evaluating instrumental activities of daily living (IADL) is an important part of procedure to diagnose dementia. The Korean-Instrumental Activities of Daily Living (K-IADL) has been used extensively in Korea. However, its cut-off score has not been reformulated since 2002. The purpose of this study was to yield a new optimal cut-off score for the K-IADL and confirm the validity of this new cut-off score with various dementia groups. Methods: We retrospectively collected a total of 2,347 patients' K-IADL data from 6 general hospitals in Korea. These patients had mild cognitive impairment (MCI) or dementia with various etiologies for cognitive impairment. We also recruited a normal control group ( n =254) from the community. Korean-Mini Mental State Examination, Short version of the Geriatric Depression Scale, Clinical Dementia Rating, and Global Deterioration Scale were administered to all participants. Caregivers completed K-IADL and Barthel Index. Results: K-IADL scores were significantly different among dementia subgroups, but not significantly different among MCI subgroups. Based on internal consistency, correlations with other scales, and factor analysis, K-IADL showed excellent reliability and validity. The new optimal cut-off score to diagnose dementia was 0.40, which gave a sensitivity of 0.901 and a specificity of 0.916. Positive predictive value for dementia using the new cut-off score was 94.2% for Alzheimer's disease, 100% for vascular dementia, and 84% for Parkinson's disease. Conclusions: Our results illustrate that the new K-IADL cut-off score of 0.40 is reliable and valid for screening impairments of daily functioning resulting from various etiologies.
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Prodromal Dementia With Lewy Bodies Manifesting as Sertraline-induced Parkinsonism: A Case Report
Kim, Jin-Hyuck,Park, Jaeseol,Yu, Kyung-Ho,Ma, Hyeo-Il,Lee, Byung-Chul,Kim, Imyel,Kim, Yun Joong Lippincott WilliamsWilkins, Inc. 2012 Alzheimer disease and associated disorders Vol.26 No.2
OBJECTIVE:: To describe a patient with prodromal dementia with Lewy bodies (DLB) manifesting as sertraline-induced parkinsonism. DESIGN:: Case report. SETTING:: Tertiary referral center. PATIENT:: A 75-year-old man who initially presented with anxiety and depression along with mild cognitive impairment, later developed drug-induced parkinsonism because of sertraline treatment, and eventually showed symptoms and signs of probable DLB. INTERVENTIONS:: Sertraline treatment for depression. MAIN OUTCOME MEASURES:: Clinical examination, magnetic resonance imaging, neuropsychologic test, and cardiac I-metaiodobenzylguanidine scintigraphy. RESULTS:: His parkinsonian symptoms, which became apparent after sertraline therapy, improved markedly after the discontinuation of the drug. When he started taking sertraline, he had no dementia but had mild cognitive impairment. However, he eventually showed most of the symptoms and signs to indicate probable DLB. CONCLUSIONS:: To our knowledge, there has been no report of sertraline-induced or aggravated parkinsonian motor symptoms in DLB patients. Our patient had a short period with neither dementia nor parkinsonism during the early stage of his illness, and this period might have been regarded as the preclinical stage of DLB in the natural course of his illness.
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Prediction of post-stroke dementia using NINDS-CSN 5-minute neuropsychology protocol in acute stroke
Lim, Jae-Sung,Oh, Mi Sun,Lee, Ju-Hun,Jung, San,Kim, Chulho,Jang, Min Uk,Lee, Sang-Hwa,Kim, Yeo Jin,Kim, Yerim,Park, Jaeseol,Kang, Yeonwook,Yu, Kyung-Ho,Lee, Byung-Chul Cambridge University Press 2017 INTERNATIONAL PSYCHOGERIATRICS - Vol.29 No.5
<B>ABSTRACT</B><B>Background:</B><P>The National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute neuropsychology protocol consists of only verbal tasks, and is proposed as a brief screening method for vascular cognitive impairment. We evaluated its feasibility within two weeks after stroke and ability to predict the development of post-stroke dementia (PSD) at 3 months after stroke.</P><B>Method:</B><P>We prospectively enrolled subjects with ischemic stroke within seven days of symptom onset who were consecutively admitted to 12 university hospitals. Neuropsychological assessments using the NINDS-CSN 5-minute and 60-minute neuropsychology protocols were administered within two weeks and at 3 months after stroke onset, respectively. PSD was diagnosed with reference to the American Heart Association/American Stroke Association statement, requiring deficits in at least two cognitive domains.</P><B>Results:</B><P>Of 620 patients, 512 (82.6%) were feasible for the NINDS-CSN 5-minute protocol within two weeks after stroke. The incidence of PSD was 16.2% in 308 subjects who had completed follow-up at 3 months after stroke onset. The total score of the NINDS-CSN 5-minute protocol differed significantly between those with and without PSD (4.0 ± 2.7, 7.4 ± 2.7, respectively; p < 0.01). A cut-off value of 6/7 showed reasonable discriminative power (sensitivity 0.82, specificity 0.67, AUC 0.74). The NINDS-CSN 5-minute protocol score was a significant predictor for PSD (adjusted odds ratio 6.32, 95% CI 2.65-15.05).</P><B>Discussion:</B><P>The NINDS-CSN 5-minute protocol is feasible to evaluate cognitive functions in patients with acute ischemic stroke. It might be a useful screening method for early identification of high-risk groups for PSD.</P>
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