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Evolution of strain throughout gallium nitride deposited on silicon carbide
김지현,M.A. Mastro,N.D. Bassim,J.A. Freitas Jr.,M.E. Twigg,C.R. Eddy Jr.,D.K. Gaskill,R.L. Henry,R.T. Holm,P.G. Neudeck,A.J. Trunek,J.A. Powell 한양대학교 세라믹연구소 2007 Journal of Ceramic Processing Research Vol.8 No.5
During GaN growth on an on-axis SiC substrate, a large density of dislocations (~109 cm−2) is unavoidably generated by the GaN/SiC misfit, uncontrolled misorientation in the substrate and defects present at the surface of the substrate. Recently a unique SiC substrate was developed with step-free and stepped mesas as well as continuous surface areas similar to a standard wafer all in close proximity. It is now possible to isolate the influence of defects and steps on the deposition of GaN on SiC. This paper provides a link between the dislocation environment and the strain state in the GaN film as well as the change of this strain with increasing thickness.
Park, Miyoung,Naidoo, Anita A.,Burns, Angie,Choi, Jin Kyu,Gatfield, Kelly M.,Vidgeon-Hart, Martin,Bae, Il-Hong,Lee, Chang Seok,Choi, Gyeyoung,Powell, Andrew J.,Park, Young-Ho,Fagg, Rajni Springer-Verlag 2018 Cell biology and toxicology Vol.34 No.2
<P>A recent hypothesis suggesting that the pharmacological target TRPV1 (transient receptor potential vanilloid subfamily, member 1) may function as a tumour suppressor, which potentially impacts the development of TRPV1 antagonist therapeutics for a range of conditions. However, little is known about the long-term physiologic effects of TRPV1 blockade in the skin. In vitro and in vivo studies suggested that the potent TRPV1 competitive antagonist AMG-9810 promoted proliferation in N/TERT1 cells (telomerase-immortalised primary human keratinocytes 1) and tumour development in mouse skin that was mediated through EGFR/Akt/mTOR signalling. We attempted to reproduce the reported in vitro and in vivo findings to further explore this hypothesis to understand the underlying mechanism and the risk associated with TRPV1 antagonism in the skin. In vitro proliferation studies using multiple methods and topical application with AMG-9810 and structurally similar TRPV1 antagonists such as SB-705498 and PAC-14028 were performed. Although we confirmed expression of TRPV1 in primary human epidermal keratinocytes (HEKn) and spontaneously immortalised human keratinocytes (HaCaT), we were unable to demonstrate cell proliferation in either cell type or any clear evidence of increased expression of proteins in the EGFR/Akt/mTOR signalling pathway with these molecules. We were also unable to demonstrate skin tumour promotion or underlying molecular mechanisms involved in the EGFR/Akt/mTOR signalling pathway in a single-dose and two-stage carcinogenesis mouse study treated with TRPV1 antagonists. In conclusion, our data suggest that inhibiting the pharmacological function of TRPV1 in skin by specific antagonists has not been considered to be indicative of skin tumour development.</P>
Nitidulidae (Coleoptera: Cucujoidea) of Vanuatu
Hadden Rachael A.,Saxton Natalie A.,Gerlach Peter S.,Nielson Parker L.,Brown Samuel D.J.,Bybee Seth M.,Powell Gareth S. 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.2
A checklist to the Nitidulidae of Vanuatu is provided based on a combination of historical museum specimens and recent field expeditions. A dichotomous key to the described species recorded from the country is provided. Specific data per island is given where available; in addition, broader distributions are outlined for each described taxon. Several undescribed taxa are listed but not described until further work can be done in the region. A discussion of the movement of invasive Nitidulidae throughout Vanuatu is also included with an emphasis on the relationship between increases in human movement and commerce and the number of invasive species present. This discussion is extended to other islands in Vanuatu that have not yet been sampled in an attempt to predict the presence of invasive species.
Li-Jessen, N. Y.,Powell, M.,Choi, A. J.,Lee, B. J.,Thibeault, S. L. LARYNGOSCOPE 2017 The Laryngoscope Vol.127 No.6
<P>Conclusions: Macrophages and fibroblasts were a major cell source of vocal fold HMGB1. Translocation of HMGB1 may be an active response to the early accumulation of IL-1 beta and TNF-alpha in the wounded vocal folds.</P>
Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting
Mark Steven Miller,Peter J. Allen,Powel H. Brown,Andrew T. Chan,Margie L. Clapper,Roderick H. Dashwood,Shadmehr Demehri,Mary L. Disis,Raymond N. DuBois,Robert J. Glynn,Thomas W. Kensler,Seema A. Khan 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.1
The Division of Cancer Prevention of the National Cancer Institute (NCI) and the Office of Disease Prevention of the National Institutes of Health co-sponsored the Translational Advances in Cancer Prevention Agent Development Meeting on August 27 to 28, 2020. The goals of this meeting were to foster the exchange of ideas and stimulate new collaborative interactions among leading cancer prevention researchers from basic and clinical research; highlight new and emerging trends in immunoprevention and chemoprevention as well as new information from clinical trials; and provide information to the extramural research community on the significant resources available from the NCI to promote prevention agent development and rapid translation to clinical trials. The meeting included two plenary talks and five sessions covering the range from pre-clinical studies with chemo/immunopreventive agents to ongoing cancer prevention clinical trials. In addition, two NCI informational sessions describing contract resources for the preclinical agent development and cooperative grants for the Cancer Prevention Clinical Trials Network were also presented.