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Lisa Humbertjean-Selton,Jérôme Selton,Nolwenn Riou-Comte,Jean-Christophe Lacour,Gioia Mione,Sébastien Richard 대한간학회 2018 Clinical and Molecular Hepatology(대한간학회지) Vol.24 No.4
Anemia appears frequently in patients with alcoholic liver disease (ALD) but has never been linked to bilateral nonarteritic anterior ischemic optic neuropathy (NAION). A 65-year-old woman with a medical history of alcoholic cirrhosis was admitted for bilateral NAION. On admission, she was found to have a low arterial pressure and severe normocytic anemia (48 g/L). The anemia was related to chronic bleeding due to antral gastritis along with other factors associated with ALD. The applied treatment consisted of urgent transfusion followed by high doses of proton-pump inhibitors, iron and vitamin supplementation, and support in lifestyle measures. Her hemoglobin levels remained stable after 2 years but the patient still suffered from visual loss. This case highlights the link between anemia and bilateral NAION in ALD patients. The optic nerve head is prone to infarction in this context due to the vascularization characteristics of ALD. Hemoglobin levels should be monitored in ALD patients to avoid the severe complication of NAION.
Tobin, John J.,Bergin, Edwin A.,Hartmann, Lee,Lee, Jeong-Eun,Maret, Sé,bastien,Myers, Phillip C.,Looney, Leslie W.,Chiang, Hsin-Fang,Friesen, Rachel IOP Publishing 2013 The Astrophysical journal Vol.765 No.1
<P>We present a study on the spatial distribution of N2D+ and N2H+ in 13 protostellar systems. Eight of thirteen objects observed with the IRAM 30 m telescope show relative offsets between the peak N2D+ (J = 2 -> 1) and N2H+ (J = 1 -> 0) emission. We highlight the case of L1157 using interferometric observations from the Submillimeter Array and Plateau de Bure Interferometer of the N2D+ (J = 3 -> 2) and N2H+ (J = 1 -> 0) transitions, respectively. Depletion of N2D+ in L1157 is clearly observed inside a radius of similar to 2000 AU (7 '') and the N2H+ emission is resolved into two peaks at radii of similar to 1000 AU (3 ''.5), inside the depletion region of N2D+. Chemical models predict a depletion zone in N2D+ and N2H+ due to destruction of H2D+ at T similar to 20 K and the evaporation of CO off dust grains at the same temperature. However, the abundance offsets of 1000 AU between the two species are not reproduced by chemical models, including a model that follows the infall of the protostellar envelope. The average abundance ratios of N2D+ to N2H+ have been shown to decrease as protostars evolve by Emprechtinger et al., but this is the first time depletion zones of N2D+ have been spatially resolved. We suggest that the difference in depletion zone radii for N2H+ and N2D+ is caused by either the CO evaporation temperature being above 20 K or an H-2 ortho-to-para ratio gradient in the inner envelope.</P>
Hepatitis B and the Dermatologist
Bastien, Michael R .,Graham , Smith, J . 대한피부과학회 1988 대한피부과학회지 Vol.26 No.4
Hepatitis B is a global health problem and an imgiortant cause of morbidity and mortality, especially in the Far East. In Korea, perinatal transmissian is presently: the most import.ant route of transmission with an almost universa.l history of past infection seen in the adult population, In future years, with the implernentation of neonatal immunoprophylaxis the population at risk will shift from neonates to older chilrdren and young adults who have failed to receive necessary booster immunizations. The need for optimal preventive practices in social are medical activities will then he increasingly more important. In this article we have reviewed some of the recent information in understanding hepartitis B, arid provided specific suggestions to asisist the ciermatologist in practiing with optimal prevention in his office. Through combined efforts the future eradication of hepatitis B may be realized.
Experimental and numerical studies of mono-strand anchorage
Marceau, D.,Bastien, J.,Fafard, M.,Chabert, A. Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.12 No.2
This paper deals with an experimental and numerical study of a mono-strand wedge anchor head mechanism. First, the experimental program is presented and monitored data such as wedge slippage, anchor deflection and strain distributions along external peripheral surfaces of the anchor head are presented and discussed. In accordance with the experimental set up, these data concern only the global behaviour of the mechanism and cannot provide valuable information such as internal stress-strains distributions, stress concentrations and percentage of yielded volume. Therefore, the second part of this paper deals with the development of an efficient numerical finite element model capable of providing mechanism of the core information. The numerical model which includes all kinematics/material/contact non-linearities is first calibrated using experimental data. Subsequently, a numerical study of the anchorage mechanism is performed and its behaviour is compared to the behaviour of a slightly geometrically modified mechanism where the external diameter has been increased by 5 mm. Finally, different topics influencing the anchorage mechanism behaviour are addressed such as lubrication and wedge shape.
Numerical study of mono-strand anchorage mechanism under service load
Marceau, D.,Fafard, M.,Bastien, J. Techno-Press 2004 Structural Engineering and Mechanics, An Int'l Jou Vol.18 No.4
Anchorage devices play an important role in post-tensioned bridge structures since they must sustain heavy loads in order to permit the transfer of the prestressing force to the structure. In external prestressing, the situation is even more critical since the anchorage mechanisms, with the deviators, are the only links between the structure and the tendons throughout the service life of the structure. The behaviour of anchorage devise may be studied by using the finite element method. To do so, each component of the anchorage must be adequately represented in order to approximate the anchor mechanism as accurately as possible. In particular, the modelling of the jaw/tendon device may be carried out using the real geometry of these two components with an appropriate constitutive contact law or by replacing these components by a single equivalent. This paper presents the numerical study of a mono-strand anchorage device. The results of a comparison between two different representations of the jaw/tendon device, either as two distinct components or as a single equivalent, will be examined. In the double-component setup, the influence of the wedge configuration composing the jaw, and the influence of lubrication of the anchor, will be assessed.
Marceau, D.,Fafard, M.,Bastien, J. Techno-Press 2003 Structural Engineering and Mechanics, An Int'l Jou Vol.15 No.6
Mechanical anchorage devices are generally tested in the laboratory and may be analyzed using the finite element method. These devices are composed of many components interacting through diverse contact interfaces. Generally, a Coulomb friction law is sufficient to take into account friction between smooth surfaces. However, in the case of mechanical anchorages, a gripping system, named herein the wedge-tendon system, is used to anchor the prestressing tendon. The wedge inner surface is made of a series of triangular notches designed to grip the tendon. In this particular case, the Coulomb law is not adapted to simulate the contact interface. The present paper deals with a new constitutive contact/gripping law to simulate the gripping effect. A parameter identification procedure, based on experimental results as well as on a finite element/neural network approach, is presented. It is demonstrated that all parameters have been selected in a satisfactory way and that the proposed constitutive law is well adapted to simulate the wedge gripping effect taking place in a mechanical anchorage device.