전남대학교병원 응급실을 통한 급성중독 실태조사

이용복,주은희,서세민,고익배,김미숙,정영녀 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

This study was aimed to take the available informations about the acute poisoning, its prevention and therapy. This survey was accomplished with acute intoxicated patients in the ER(emergency room) of Chonnam National University Hospital during 42 months from Jan.1986 to June 1989. The intoxicated patients occupied 5.8% of total ER patients (47007 cases). The average of intoxicated patients per day in ER was 2.13. On sex analysis, males occupied 49.3% and females 50.7%. On the motive of poisoning, intoxication by accident occupied 42.1%, by suicide attempt 39.4%, and by the others 18.5%. Poisoning substances included CO poisoning(23.9%), agricultural agents (22.8%), drugs(15.4%), chemicals(14.6), bites, rodenticides and food poisoning. The mortality of intoxicated patients was 8% (216 cases) and the major death-inducing substance was paraquat(39.8%). To decrease and prevent these acute poisonings, we suggest, first, that agricultural agents and psychotropic drugs must be carefully controlled by authorities, second, the informations on the acute poisoning continuously collected, third, poison control center established as soon as possible.

전신 마취중 Sodium Nitroprusside 가 중심동맥압과 심박수에 미치는 영향

이명애,주경란,김혜경,김병두,안창근 대한마취과학회 1980 Korean Journal of Anesthesiology Vol.13 No.4

The time course and magnitude of change in mean arterial pressure (MAP) and heart rate (HR) following a single rapid intravenous injection of 1ug/kg and 2ug/kg of sodium nitro prusside(SNP) were determined in 10 anesthetized patients. The results were as follows: 1) MAP began to decrease 15 seconds after both 1ug/kg and 2ug/kg of SNP and was maximal after 90 seconds with return toward control apparent by 3 minutes and complete after 5 to 6 minutes(Fig. 1). 2) The magnitude of decrease in MAP after SNP was dose related whereas onset and duration of blood pressure changes were not influenced by the SNP dose. 3) HR did not change significantly after either dose of SNP. SNP is a potent, rapid acting antihypertensive drug which produces arteriolar vasodilation and prevention of hypertension and is particularly important in patients with decreased myocardial reserve or intracranial pathology.

단조용 환봉이 유도가열실험 및 이론 해석에 관한 연구

최진호,이원재,강성욱,주성호,조봉환,김병화 대한금속재료학회(대한금속학회) 1999 대한금속·재료학회지 Vol.37 No.12

A solid type crankshaft, one of the most important part of medium size marine engine, is manufactured by forging method. The induction heating system(600 ㎾ = 100%, 190∼200 ㎐) is used to heat rounded bar(Ø285 ㎜) up to 1200℃ for the forging. Numerical analysis was performed on the heating process at various operating conditions by applying boundary conditions based on theoretical approach. Experiments were also performed on the same type of mended bar to confirm the simulation results. Experimental results showed that the induction heating phenomena were effected by the phase transformation at A_(c₁) A_(c₃) temperature range, the magnetic transformation at A₂ (curie point) temperature range and the mass effect of large volume of rounded bar. At the 62% power, our induction heating system showed the maximum efficiency and the heating time was about 40∼50 minutes.

전남대학교병원 입원환자 약제 알러지에 관한 연구

주은희,서세민,이용복,고익배 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

This study was accomplished to take the available informations about drug allergy, its prevention and therapy. Drug allergy was surveyed with the inpatients in Chonnam National University Hospital during 14 days from Oct, 5 to Oct. 18, 1989. The medical doctors of the ward of the clinical department wrote the drug allergy survey card and our team members reviewed the chart profiles to perform exactly. The drug allergic patients occupied 3.2% of total 657 inpatients. The longer the hospitalization period, the higher the ratio of the occurrence of drug allergy. On the allergy-induced drug, cephalosporins occupied 10 cases, penicillins 7 cases, NSAIDS 3 cases and the miscellaneous drugs 8 cases. On the route of drug administration in the case of drug allergy, parenteral route occupied 16 cases and oral route 5 cases. The symptom of drug allergy included skin eruption(16 cases), palpitaion(6 cases), drug fever(4 cases), itching sense(3 cases), flushing face(1 case) and syncope(1 case). The major test of drug allergy was skin test. On the onset time of drug allergy after starting drug therapy, 3 cases occurred immediately, 4 cases after 1 day-2 days, 5 cases during 2 days-1 week and 5 cases after 2 weeks.

항고혈압약물 사용 실태조사

주은희,서세민,이용복,고익배 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

Recently the frequency of hypertension and its complication became increased. The use of antihypertensive drug was surveyed in order to take the basic materials about the treatment of hypertension. This study was accomplished with the prescription sheets and chart profiles of the two hundred hypertensive patients of the internal medical department in Chonnam National University Hospital during 6 months from Jan. 1988 to June 1988. Fifteen percent of hypertensive patients had family history. On analysis of hypertension-related complication, 40% occupied cardiovascular diseases such as angina pectoris, myocardial infarction and congestive heart failure. Carl analysis of the combination of antihypertensive drug, 60% occupied the combination of diuretic, β-blocker,(sympatholytic) and Ca-antagonist. The use of sympatholytic except for α, β-blocker was trending toward decrease, but the use of Ca-antagonist toward increase.

비스테로이드성 소염진통제의 약물상호작용에 관한 연구

주은희,이령인,조행남,이용복,고익배 전남대학교 약품개발연구소 1997 약품개발연구지 Vol.6 No.1

According to the test increase of NSAID-uses, the possibility of the occurrence of drug interaction became increased. So we surveyed the drug interaction of NSAIDS in order to inhibit NSAID-related side defect. This study was accomplished for the NSAID-administered inpatients in Chonnam University Hospital at one day from Jan. to June in 1991. The NSAID-administered inpatients occupied 20.2% of total 3598 drug-administered inpatients On clinical department, orthopedic surgery occupied the highest value of 15.1% of NSAID-administered patient On the route of NSAID administration, injection occupied 32.7%, internal medicine 61.2%, external medicine 0.3% and the combination of injection & internal medicine 5.8%. On NSAID dosage form, injection occupied 38.5%. internal medicine 67% and external medicine 0.396. On the number of used NSAID, ale occupied 89.8%, two 9.2% arid three 1%. The average number of NSAID used by a patient was 1.1. The possible occurrence rate of drug interaction of NSAIDS was 33.1%. As the number of teed drug increased, the occurrence possibility of drug interaction of NSAIDS tended to increase. The possible occurrence rate of drug interaction of NSAIDS reached 100% in above 21 drug-used casts. The harmful interaction of NSAIDS could occur such as digitalis toxicity with digoxin in 3 cases, hypoglyocemia with antidiabetics in 8 cases, nephrotoxicity with diuretics in 57 cams, hemorrhage with anticoagulants or thrombolytics in 57 case, gastrointestinal hemorrhage with NSAIDS in 63 cases, the decease of antihypertensive effect with antihypertensives in 104 roses and the decrease of anti-inflammatory effect with antacids in 135 uses. So we should carefully monitor the drug interaction of NSAIDS and provide drug information to health team in order to prevent the harmful interaction of NSAIDS.

종합병원 입원환자 다제병용에 관한 실태조사

이용복,주은희,서세민,고익배,김희정 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

According to the recent tendency of polypharmacy in clinical department, the probability of the occurrence of drug interaction and adverse effect became increased. This study on the polypharmacy was accomplished for the 1760 inpatients in Chonnam National University Hospital at one day of January, April and July in 1990, in order to obtain the available informations for the monitoring of polypharmacy-related drug interaction and side effect, On the route of drug administration, injection occupied 42.5%, the combination of internal medicine and injection 34.6%, thus these two cases 77.1%. On drug dosage form, injection occupied 83.4%, internal medicine 54% and external medicine 7.6%. The case to use 4 drugs occupied the highest value of 11.2% and the case to use 1 drug occupied 8.6%. The highest number of used drug was 28 and 90% of the patients used less than 12 drugs. The average number of used drug per patient was 6.3. The average number of used drug in surgical department was 6, in internal medical department 6.5 and in otorhinolaryngological department the highest value of 7.1. The average number of used drug in infants and pediatrics was 5.2, in 21-50 year old adults 6.2 and in above 71 year old geriatrics 6.9. As age increased, the number of used drug tended to increase. So we should make a thorough investigation of polypharmacy-related drug interaction and side effect, especially to geriatrics.

종합병원 외래환자 다제병용에 관한 실태조사

주은희,조행남,서세민,이용복,고익배 전남대학교 약품개발연구소 1997 약품개발연구지 Vol.6 No.1

This study was accomplished to obtain the basic materials about polypharmacy-related drug interaction and side effect. The polypharmacy in relation to the route of drug administration, dosage form, clinical department and age was surveyed with the 1,632 outpatients in Chonnam University Hospital at one day of January, March and May in 1991. On the route of drug administration, internal medicine occupied 81.2%, the combination of internal medicine & external medicine 7.3%, external medicine 3.9%, injection 3.8% and the combination of internal medicine & injection 3.4%. On drug dosage form, internal medicine occupied 92.1%, injection 7.6% and external medicine 11.6%. The case to use 4 drugs occupied the highest value of 26.2% and the case to use 1 drug 8.4%. The highest number of used drug was 14 and 90% of the patients used less than 6 drugs. The average number of used drug per patient was 4.2. The average number of used drug in ophthalmological department was the lowest value of 2.4, in surgical department 4.4, in internal medical department 4.7 and in neurological department the highest value of 5.7. The average number of used drug in infants and pediatrics was 2.8, in 15-20 year old youth 3.6, in 21-60 year old adults 4.3 and in above 61 year old geriatrics 4.7. As age increased, the number of used drug tended to increase.

Al 함유 13%Cr 스테인리스강의 표면 질소침투 열처리에 미치는 첨가원소 탄소의 영향 : 13%Cr 스테인리스강의 고질소 표면침투 열처리

성장현,주동원,김기돈,유대경,박진욱 한국열처리공학회 2000 熱處理工學會誌 Vol.13 No.3

This study aims to investigate the effect of carbon content on the surface nitrogen permeation of 13%Cr-1.8%Al alloyed stainless steels. The surface nitrogen permeation was performed at 1050℃-1200℃ in the 1㎏/㎠ nitrogen gas atmosphere. The nitrogen permeated surface layer of the specimen containing 0.03%C consists of AlN, martensite and retained austenite phases, while the surface layer of the specimen containing 0.14%C appears the AlFe₃C_x phase including former three phases. The specimen containing 0.14%C shows lower total case depth than that containing 0.03%C at the nitrogen permeation temperatures of 1050℃ and 1100℃, while the total case depth of the specimen containing 0.14%C is remarkably increased at the temperature of 1150℃ and 1200℃ due to the increase in the retained austenite content. Martensitic phase, AlN and AlFe₃C_x precipitate of the nitrogen permeated surface layer cause to increase the surface hardness of 550∼600Hv.

5083 Al 합금 용접재의 조직 및 저온 인장성질에 미치는 시효처리의 영향

성장현,이해우,주동원,이준희,이태청 한국열처리공학회 2000 熱處理工學會誌 Vol.13 No.1

The microstructural characteristics and low temperature tensile properties between 25℃ and -196℃ for as-welded and age hardened specimen by using Al 5083-H321 for base metal, 5083-5356 and 5083-4043 weldments have been investigated. The hardness of 5083-5356 weldment decreases with aging treatment, whereas the weld region of 5083-4043 weldment shows remarkable increase in hardness after aging due to the precipitation of fine Si particle at the grain boundaries and interiors. Low temperature tensile properties of 5083 Al base metal, 5083-5356 and 5083-4043 weldments appear to be the increment of tensile strengths and elongations at the room temperature and -196℃, while the decrement of tensile properties around -50℃ is shown. Through the observation of fine serration to fracture in the stress-strain curve and tensile fractography, the increment of localized deformation leading to promote the neck initiation and the increment of the dimple size cause to decrease in tensile strengths and elongations around -50℃. For the tensile specimen of the 5083 base metal, 5083-5356 and 5083-4043 weldments, the reason to increase in elongation after solution and aging treatment is the diminishment of fine pit, the resolution of Mg into the matrix and the spheridization of the eutectic Si.