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Mathematical Modeling of MNP Hyperthermia: Development toward the In-vivo Cancer Therapy
Izaz Raouf(이자즈 라우프),Heung Soo Kim(김흥수) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Lately, the in-vitro studies of magnetic nanoparticles (MNPs) hyperthermia gained significant concentration because of severity of cancer therapy in the in-vivo culture. The numerical studies play a crucial role in optimizing the therapeutic conditions to achieve the actual therapys optimum parameters. The presented studies aim to develop such a comprehensive numerical model that directly correlates the MNP hyperthermia parameters to the thermal response of the in-vitro model using optimization through linear response theory (LRT). Various parameters, such as applied magnetic field (AMF) strength, field frequency, and MNPs concentration, are selected. Their effect is investigated for the thermal distribution of ferrofluid system with space and time. The reliability of presented model is evaluated via the correlation analysis for the specific loss power (SLP) calculations. The proposed model is a reliable source to investigate the ferrofluid thermal distribution for ferrofluid preparation.