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- 검색키워드
- 저자 : Irimie, Sorina (검색결과 4 건)
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Type-specific Prevalence of Human Papillomavirus by Cervical Cytology among Women in Brasov, Romania
Moga, Marius Alexandru,Irimie, Marius,Oanta, Alexandru,Pascu, Alina,Burtea, Victoria Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
The oncogenic role of human papillomavirus (HPV) in triggering cervical cancer, the second most common cancer in women worldwide, is well established. Romania ranks in first place in Europe in terms of the incidence of cervical cancer. Geographical widespread data on HPV type-distribution are essential for estimating the impact of HPV vaccines and cervical cancer screening programmes. In this study we aimed to identify the prevalence of HPV genotypes and to establish correlations with abnormal cervical cytology among the female population of Brasov County, Romania. A total of 1,000 women aged 17.3-57 years, attending routine cervical examination in the Obstetrics and Gynecology Hospital of Brasov, Romania, and undergoing both cytological examination and HPV genotyping were screened. Infection with 35 different HPV genotypes was detected in 39.6% of cytological specimens. Overall HPV infections were highest in young women under 25 years (p<0.0001), in which cervical cytological abnormalities also reached the highest prevalence. Patients infected by HPV-16 or HPV-18 showed the highest prevalence of cervical cytological abnormalities. Some 48.2% of women with abnormal cytology were infected with high-risk HPV types whereas less than 3% of them were infected only with low-risk HPV types. Our study showed that the prevalence of high-risk HPV infection among Romanian women is higher compared to other studies in other geographic areas. Thus, we consider that in areas where there is an increased prevalence of high-risk HPV infections, HPV genotyping should be performed in all women aged between 18 and 45 years, and Pap test should be performed every 6 months in women with high-risk HPV infection, even those with previous normal cervical cytology.
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Tee, Guat Hiong,Aris, Tahir,Rarick, James,Irimie, Sorina Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Tobacco consumption continues to be the leading cause of preventable deaths globally. The objective of this study was to examine the associaton of selected socio-demographic variables with current tobacco use in five countries that participated in the Phase II Global Adult Tobacco Survey in 2011 - 2012. Materials and Methods: We analysed internationally comparable representative household survey data from 33,482 respondents aged ${\geq}15years$ in Indonesia, Malaysia, Romania, Argentina and Nigeria for determinants of tobacco use within each country. Socio-demographic variables analysed included gender, age, residency, education, wealth index and awareness of smoking health consequences. Current tobacco use was defined as smoking or use of smokeless tobacco daily or occasionally. Results: The overall prevalence of tobacco use varied from 5.5% in Nigeria to 35.7% in Indonesia and was significantly higher among males than females in all five countries. Odds ratios for current tobacco use were significantly higher among males for all countries [with the greatest odds among Indonesian men (OR=67.4, 95% CI: 51.2-88.7)] and among urban dwellers in Romania. The odds of current tobacco use decreased as age increased for all countries except Nigeria where. The reverse was true for Argentina and Nigeria. Significant trends for decreasing tobacco use with increasing educational levels and wealth index were seen in Indonesia, Malaysia and Romania. Significant negative associations between current tobacco use and awareness of adverse health consequences of smoking were found in all countries except Argentina. Conclusions: Males and the socially and economically disadvantaged populations are at the greatest risk of tobacco use. Tobacco control interventions maybe tailored to this segment of population and incorporate educational interventions to increase knowledge of adverse health consequences of smoking.
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The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
Daiana Cosmina Temian,Laura Ancuta Pop,Alexandra Iulia Irimie,Ioana Berindan-Neagoe 한국유방암학회 2018 Journal of breast cancer Vol.21 No.3
Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remains elusive to targeted therapies—the triple-negative breast cancer. This immunohistochemically defined subtype is resistant to both endocrine and targeted therapies, leading to its poor prognosis. A field that is of great promise in current cancer research is epigenetics. By studying the epigenetic mechanisms underlying tumorigenesis— DNA methylation, histone modifications, and noncoding RNAs— advances in cancer treatment, diagnosis, and prevention are possible. This review aims to synthesize the epigenetic discoveries that have been made related to the triple-negative breast cancer.
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Voices of the fisher king: Narratives of older travellers’ religious journeys
Anna Irimiás,Ariel Mitev,Gábor Michalkó 한국마케팅과학회 2018 마케팅과학연구 Vol.28 No.3
Older adults in countries with a relatively high standard of living are regarded as a highly influential consumer segment. However, the economically disadvantaged, invalids and lone travelers all face a variety of external and internal barriers to travel and social interaction. By contrast, “quest archetype” journeys, such as religious tourism and pilgrimages, provide opportunities for companionship, whilst also helping to alleviate an individual’s negative perceptions of ageing and later life. The main objectives of the research were to explore how older adults report their archetypal experiences and how they are perceived by the young. The generic purposive sampling comprised 345 Hungarian respondents. In the multi-generational sample, in-depth interviews were carried out with the youngest (23%) and the oldest (21%) age groups to explore the different perceptions of ageing. Narrative segments were analyzed within the framework of one particular archetypal quest, the legend of the Holy Grail. The study here attempts advances knowledge of the best approaches to assessing those travel narratives which employ archetypal legends. At the same time, service providers in the field of religious tourism can also benefit from the results in their management of holy sites with the needs and wishes of the older generation in mind.
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