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        Effect of dexamethasone gargle, intravenous dexamethasone, and their combination on postoperative sore throat: a randomized controlled trial

        기승희,Myoung Inwook,Cheong Soonho,임세훈,Cho Kwangrae,Kim Myoung-hun,Han Yongjae,오민경,Park Yohan,Kim Kwanghee,Lee Jeonghan 대한마취통증의학회 2020 Anesthesia and pain medicine Vol.15 No.4

        Background: Postoperative sore throat (POST) is a complication that decreases patient satisfaction and increases postoperative complaints. The present study was conducted to investigate effects of gargling with dexamethasone, intravenous dexamethasone injection and the combination of the two on the incidence and severity of POST.Methods: Study participants were 96 patients who had undergone laparoscopic cholecystectomy, randomly allocated into three groups. Group G gargled with 0.05% dexamethasone solution and were infused intravenous 0.9% normal saline before general anesthesia; group I gargled with 0.9% normal saline and were infused intravenous 0.1 mg/kg dexamethasone; group GI gargled with 0.05% dexamethasone solution and were infused intravenous 0.1 mg/kg dexamethasone. The incidence and severity of POST, hoarseness and cough were evaluated and recorded at 1, 6, and 24 h after the surgery.Results: There were no significant differences in the total incidence of POST up to 24 postoperative hours among Group G, Group I and Group GI (P = 0.367, Group G incidence = 34.38%, [95% confidence interval, 95% CI = 17.92–50.83], Group I incidence = 18.75%, [95% CI = 5.23–32.27], Group GI incidence = 28.13%, [95% CI = 12.55–43.70]). The other outcomes were comparable among the groups.Conclusions: In patients who had undergone laparoscopic cholecystectomy, gargling with 0.05% dexamethasone solution demonstrated the same POST prevention effect as intravenous injection of 0.1 mg/kg dexamethasone. The incidence and severity of POST were not significantly different between the combination of gargling with 0.05% dexamethasone solution and intravenous injection of 0.1 mg/kg dexamethasone and use of each of the preventive methods alone.

      • Effect of bleeding on the surgical field in dexmedetomidine infusion patients undergoing endoscopic sinus surgery under general anesthesia

        Kwangrae Cho,Inwook Myoung 조선대학교 의학연구원 2020 The Medical Journal of Chosun University Vol.45 No.2

        Background: In order to secure an ideal surgical field for endoscopic sinus surgery (ESS), it is necessary to reduce intraoperative bleeding. Intraoperative intra-nasal bleeding is influenced by various anesthetics. The present study focuses on the differences between sevoflurane/ remifentanil (SR)-based anesthesia and sevoflurane/remifentanil/dexmedetomidine (SRD)- based anesthesia in terms of surgical field conditions. Methods: American Society of Anesthesiologists physical status class I or II patients undergoing ESS were randomly assigned to the SR (n=36) or SRD (n=32) group. In order to assess the visibility of the surgical field, the level of intraoperative bleeding was rated on a 6-point numeric rating scale (NRS). Computed tomography findings were used to evaluate the extent of each preoperative surgical lesion, as high (>12) vs. low (≤12) Lund-Mackay (LM) score. A single surgeon was in charge of rating the visibility of the surgical field on an NRS every 5 minutes, and the worst NRS was used as a representative value for each group. Results: The NRS of the surgical field was not significantly different between the two groups (p=0.089). However, in the high-LM score patients, the NRS of the surgical field was significantly better in the SRD group than in the SR group (p=0.009). Conclusions: In the high- LM score patients, SRD-based anesthesia resulted in better surgical field conditions for ESS than did SR-based anesthesia. Therefore, we conclude that SRD-based anesthesia is beneficial in ESS.

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