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- 저자 : Inpyo Jeon (검색결과 4 건)
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Inpyo Jeon,Gwang Pyo Jung,서한길,Ju Seok Ryu,Tai Ryoon Han,Byung-Mo Oh 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.2
Objective To investigate the proportion of aspiration pneumonia cases among patients with community-acquired pneumonia in Korea.Methods This retrospective study included patients with community-acquired pneumonia who had been admitted to the emergency department of a university-affiliated tertiary hospital in Gyeonggi Province, Korea between January 1, 2016 and December 31, 2016. Among these patients, those with aspiration pneumonia were identified using ICD-10 codes (J69.*). Patients with recurrent pneumonia were excluded, as were those who were immunocompromised. The proportion of cases of aspiration pneumonia was calculated, and the characteristics and clinical outcomes of patients with aspiration pneumonia and non-aspiration pneumonia were compared. Results The proportion of aspiration pneumonia cases among patients with community-acquired pneumonia was 14.2%. Patients with aspiration pneumonia were significantly more likely to be older (p<0.001) and male (p<0.001), and to have a higher confusion, uremia, respiratory rate, blood pressure, and age ≥65 years (CURB-65) score (p<0.001) as compared to patients with non-aspiration pneumonia. They were also more likely to require admission to the intensive care unit (p<0.001) and a longer hospital stay (p<0.001). Conclusion Aspiration pneumonia accounts for 14.2% of all cases of community-acquired pneumonia in Korea. These data may contribute to the establishment of healthcare strategies for managing aspiration pneumonia among Korean adults.
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Lee, Jung-Yun,Jeon, InPyo,Kim, Jae Weon,Song, Yong-Sang,Yoon, Jae-Moon,Park, Sang Min BMJ 2013 International journal of gynecological cancer Vol.23 No.3
<B>Objective</B><P>The objective of this study was to evaluate the epidemiologic association between diabetes and risk of ovarian cancer.</P><B>Methods</B><P>We searched PubMed, EMBASE, and The Cochrane Library for observational studies on the association between diabetes and ovarian cancer. Cohort studies that reported relative risks (RRs) and case-control studies that showed odds ratios were included in the analysis. Summary RRs with 95% confidence intervals (CIs) were calculated with a random-effects model.</P><B>Results</B><P>A total of 19 studies from 18 articles (7 case-control studies and 11 cohort studies) met the inclusion criteria. Combining data from all studies, diabetes was associated with an increased risk of ovarian cancer, compared with no diabetes (summary RR of ovarian cancer incidence, 1.17; 95% CI, 1.02-1.33). In cohort and nested case-control studies, patients with diabetes had statistically significant increased risk of ovarian cancer (RR, 1.16; 95% CI, 1.01-1.33), without significant heterogeneity (<I>I</I><SUP>2</SUP> = 27; <I>P</I> = 0.172). Among studies that control for age, body mass index, smoking, and alcohol, a prominent association between diabetes and ovarian cancer was found (RR, 1.55; 95% CI, 1.11-2.19).</P><B>Conclusions</B><P>This study suggests that women with diabetes have a moderately increased risk of ovarian cancer.</P>
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CHUNG, Jin Woong,JEON, Jun-Ho,YOON, Suk-Ran,CHOI, Inpyo Wiley (Blackwell Publishing) 2006 The Journal of Dermatology Vol.33 No.10
<P>Vitamin D(3) upregulated protein 1 (VDUP1) is a 46-kDa multifunctional protein, initially isolated in HL-60 cells as a protein of which expression is upregulated by vitamin D(3) administration. Subsequently, it was identified independently by investigators from diverse scientific backgrounds as a thioredoxin binding protein that negatively regulates the expression and the activity of thioredoxin, and is thus involved in redox regulation. Further studies have revealed that VDUP1 plays multiple roles in a wide range of cellular processes such as proliferation or apoptosis. Recently, it has been reported that VDUP1 is also involved in the immune system via positive regulation of natural killer development. In addition, VDUP1 has been revealed to be associated with the fatty acid utilization. In the present review, we discuss the novel aspects of VDUP1 function as well as the historical background of VDUP1. Future studies will explore the diagnostic and therapeutic potential of modulating the function of VDUP1 in vivo.</P>
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Jeong, Mira,Piao, Zheng-Hao,Kim, Mi Sun,Lee, Suk Hyung,Yun, Sohyun,Sun, Hu-Nan,Yoon, Suk Ran,Chung, Jin Woong,Kim, Tae-Don,Jeon, Jun Ho,Lee, Jiwon,Kim, Hyun-Nam,Choi, Je-Yong,Choi, Inpyo Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.4
<P>Hematopoietic stem cells (HSCs) are maintained in a quiescent state in bone marrow (BM) niches by intrinsic and extrinsic signals. The mechanisms regulating the quiescence and mobilization of HSCs, however, remain unclear. In this study, we report that the expression of thioredoxin-interacting protein (TXNIP) is decreased during HSC activation. In Txnip(-/-) mice, the long-term reconstituting HSC population is decreased and exhausted, and its capacity to repopulate is rapidly lost. These effects are associated with hyperactive Wnt signaling, an active cell cycle, and reduced p21 expression under conditions of stress. TXNIP deficiency reduced the CXCL12- and osteopontin-mediated interaction between HSCs and the bone marrow, and impaired homing and retention in the osteoblastic niche, resulting in mobilized HSCs. Therefore, we propose that TXNIP is essential for maintaining HSC quiescence and the interaction between HSCs and the BM niche.</P>
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