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RISS 인기검색어
- 검색키워드
- 저자 : Injae Suh (검색결과 6 건)
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Suh, Guk-Hee,Jung, Hee Yeon,Lee, Chang Uk,Oh, Byoung Hoon,Lee, Sang-Kyu,Lee, NamJin,Kim, JaeHyun,Kee, Baik Seok,Ko, Daekwan,Kim, Young-Hoon,Ju, Young-Su,Hong, InJa,Choi, Sungku S. Karger AG 2005 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol.21 No.1
<P><I>Objective:</I> To investigate the effect of the apolipoprotein E (ApoE) ε4 allele on the efficacy and tolerability of galantamine treatment. <I>Methods:</I> A total of 202 patients with mild to moderate Alzheimer’s disease participated in a 16-week, prospective, multi-center, randomized, double-blind galantamine trial in a Korean population. Patients were assessed at baseline and after 4, 8 and 16 weeks of randomized treatment using the 11-item cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-cog/11), the Clinician’s Interview-Based Impression of Change plus Caregiver Input (CIBIC-plus), the Disability Assessment for Dementia Scale (DAD), the Behavioural Pathology in Alzheimer’s Disease Rating Scale (BEHAVE-AD) and adverse events. ApoE genotypes were determined for all subjects. <I>Results:</I> Of the 202 subjects, 115 carried at least one ApoE ε4 allele and 87 did not. In both ApoE ε4 carriers and ApoE ε4 noncarriers, significant improvements were detected relative to baseline on ADAS-cog/11, CIBIC-plus, DAD and BEHAVE-AD. ApoE ε4 noncarriers showed better improvement in mean total BEHAVE-AD score and mean psychosis (delusions and hallucinations) subscale score than ApoE ε4 carriers. The incidence of weight loss was significantly higher in ApoE ε4 carriers (n = 11; 9.6%) than in ApoE ε4 noncarriers (n = 1; 1.2%) during this 16-week study, even though 92% of patients who complained of weight loss completed this 16-week trial successfully. <I>Conclusion:</I> ApoE ε4 genotype does not affect galantamine-related improvements in cognition, global rating, function and behavior. Longer prospective studies with larger patient populations are required to confirm these new findings.</P><P>Copyright © 2006 S. Karger AG, Basel</P>
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서문자,김인자 대한류마티스 건강전문학회 1997 근관절건강학회지 Vol.4 No.2
The lack of a comprehensive theory describing the mechanism of adaptation scientifically has been one of the limiting factors for the development of nursing intervention of patients with chronic illness. Since Roy's theory provides the general conceptual framework depicting adaptation process with structural stimuli and control mechanism, it is appropriate to understand the process of adaptation. But in Roy's theory, the propositions about cognator and regulator as control mechanisms are not clearly defined. For this reason, most of the previous researches applying the Roy's theory have disregarded the study of cognator and regulator. For the patients with chronic illness such as rheumatoid arthritis, it was reported that adaptation states were different for the same stimuli due to the difference of the control mechanism. Moreover in nursing it is important to identify the control mechanism which can be and must be intervened by nurses. It was the Lazarus and Folkman's theory that proposed the control mechanism. They suggested that individual differences in the reaction against the perceived stress are due to the difference in appraisal and coping. Therefore, the synthesis of Roy's and Lazarus and Folkman's propositions might help to clearly understand the mechanism of adaptation. From this point, a theoretical framework has been developed and tested. The subjects were the 297 patients who had been diagnosed rheumatoid arthritis and attended the outpatient clinic. A hypothetical prediction model of adaptation was tested by the covariance structure analysis with PC-LISREL 7.13. As a result, the overall fit was good(x²=78.83, p=0.00 ; GFI=0.96 : AGFI=0.90 ; RMR=0.04) for the hypothetical model. In the final model added GA(5, 1), the overall fit was increased (x²=57.82, p=0.003 ; GFI=0.97 ; AGFI=0.93 ; RMR=0.036). Except the fact that illness symptoms affected physical adaptation directly, it was supported that focal and contextual stimuli affected physical and psychosocial adaptation through appraisal and coping. Therefore, it was asserted that the synthesis of two theory's propositions was appropriate. So this model would be useful for the theoretical framework in the nursing practice. And this study synthesizing and testing the theory might contribute to establish nursing's scientific base.
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류마티스 관절염 환자에서 자기효능에 영향을 미치는 요인
김인자,서문자 성인간호학회 1999 성인간호학회지 Vol.11 No.1
The demographic, psychological, social and disease characteristics were analyzed to find the sources of self-efficacy(the expectation about one's ability to engage in or execute in a behavior) in the ability to engage in or execute in a behavior) in the 297 patients with rheumtoid arthritis. Except for religion and client's job, the demographic characteristics such as age, sex, partner's job, income, and educational level were found to be significantly related to self-efficacy. In the group of older age, female, lower income, job with less prestige, and lower educational level, the self-efficacy was lower than the other group. Depression which measured as psychological characteristics was significantly related to self-efficacy. Social characteristics, such as social support and relationship with health professionals, were positively related to self-efficacy except for social network. Getting a high score in the area of relationship with health-professionals means that the patients perceive that they can express themselves or decide on their own activities as much as they want. Among the disease characteristics, only disease duration was not significantly related to self-efficacy. The self-efficacy shows a tendency to decrease with time. Pain was negatively related to self-efficacy. Possible activity level was positively related to self-efficacy. To analyze the variables which affect self-efficacy, stepwise regression was implemented. As a result, about 42% of the self-efficacy were explained by possible activity level, depression, social support, and pain in that order. Based upon these results, it is recommended that the nurses who are in change of or maintain the behavior of patients with rheumatoid arthritis consider the demographic characteristics such as age, sex, et al. Also programs which decrease the pain and depression and increase the social support and activity levels are recommended to be developed.
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