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Lee, Inae,Kim, Sunmi,Park, Suhyeon,Mok, Sori,Jeong, Yunsun,Moon, Hyo-Bang,Lee, Jangwoo,Kim, Sungkyoon,Kim, Hai-Joong,Choi, Gyuyeon,Choi, Sooran,Kim, Su Young,Lee, Aram,Park, Jeongim,Choi, Kyungho Elsevier BV 2019 Science of the Total Environment Vol.688 No.-
<P><B>Abstract</B></P> <P>Chemicals such as phthalates and phenolics have been associated with metabolic markers in humans. However, most studies have only looked at a limited number of chemicals, and little is known about their potential effects on adipokines in humans. In the present study, the associations between dozens of urinary chemicals, including phthalate metabolites and phenolics, and markers related to insulin resistance as well as major adipokines, were assessed among the women of reproductive age (<I>n</I> = 459, between 20 and 48 years of age) recruited from major cities in Korea between 2015 and 2016. Adipokines such as adiponectin and leptin, and insulin resistance related markers such as glucose and insulin, were analyzed in serum. Associations between urinary chemicals and the adipokines or insulin resistance related markers were assessed in two steps. First, ordinary least squares (OLS) regression was used to assess the association of each urinary chemical with the adipokines or insulin resistance related markers (single-pollutant model). Second, several chemicals were selected using elastic net regression and were subsequently analyzed with OLS regression model (multi-pollutant model), considering simultaneous exposure to multiple chemicals. In both single- and multi-pollutant models, several urinary chemicals consistently showed significant associations with adipokines or the insulin resistance related markers. The sum of di-(2-ethylhexyl) phthalate metabolites (ΣDEHPm) and ethyl paraben (EtP) were associated with increased serum adiponectin levels. Urinary ΣDEHPm levels also showed positive associations with fasting glucose. Moreover, urinary mono-methyl phthalate (MMP), mono-isobutyl phthalate (MiBP), and bisphenol S (BPS) levels showed positive associations with the homeostasis model assessment for insulin resistance (HOMA-IR). Interestingly, urinary propyl paraben (PrP) levels showed a negative association with HOMA-IR, in both models. Our observations show that among many consumer chemicals, phthalates may affect serum adipokines, and thus glucose, and insulin resistance in adult females. Further confirmation is warranted in other populations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Urinary chemicals and metabolism related markers were measured in women of reproductive age. </LI> <LI> Multiple chemicals were considered in statistical models for adipokines and insulin resistance. </LI> <LI> Sum of DEHP metabolites and EtP were positively associated with serum adiponectin levels. </LI> <LI> Sum of DEHP metabolites was significantly associated with increased fasting glucose. </LI> <LI> MiBP was significantly associated with for increased HOMA-IR. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Inae,Kim, Sunmi,Kim, Ki-Tae,Kim, Sungkyoon,Park, Suhyun,Lee, Hyojin,Jeong, Yunsun,Lim, Jae-Eun,Moon, Hyo-Bang,Choi, Kyungho Elsevier 2018 Environment international Vol.117 No.-
<P><B>Abstract</B></P> <P>Bisphenol A (BPA) is one of the most widely used chemicals in various consumer products. In thermal papers such as receipts and tickets, BPA is used as a heat-activated developer. Cashiers are therefore suspected to be a vulnerable group of exposure to BPA, but neither contribution of receipt handling to the total body burden of BPA among cashiers, nor related health effects are well characterized. Female cashiers (n = 54) were recruited from seven retail shops of a major supermarket chain in Korea, and urinary levels of BPA and metabolic syndrome (MetS) related biomarkers were measured. In order to estimate the contribution of receipt handling to the body burden of BPA, an intervention was designed on the use of gloves: the subjects were asked not to wear gloves during the work for one week, and in the following week, to wear gloves. Urine samples were collected at pre-shift and post-shift for the first two consecutive days in each week, and urinary BPA concentrations were measured. In cashiers without gloves, about a two-fold increase in urinary BPA concentrations was observed after work-shift. When the cashiers wore gloves, however, urinary BPA levels showed no changes. Higher urinary BPA concentrations were associated with greater levels of fasting insulin and insulin resistance. Our observation shows that receipt handling among the cashiers could double the BPA exposure levels at post-shift compared to those at pre-shift, and use of simple protective equipment such as gloves could effectively reduce the BPA exposure levels.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Contribution of receipt handling to body burden of BPA was determined in cashiers. </LI> <LI> Without gloves, urinary BPA levels increased by two folds following work-shift. </LI> <LI> Use of gloves could efficiently prevent occupational exposure to BPA. </LI> <LI> Urinary BPA levels were associated with increased insulin levels and resistance. </LI> </UL> </P>