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RISS 인기검색어
- 검색키워드
- 저자 : Imad Abdelhamid El Haci (검색결과 4 건)
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Imad Abdelhamid El Haci,Wissame Mazari,Fawzia Atik-Bekkara,Fayçal Hassani,Mohamed Gherib 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.2
This scientific work involves a phytochemical study of a medicinal plant endemic to the south of Algeria: Limoniatrum feei Girard (Batt.). The study of the antioxidant effects and the evaluation of the cytotoxicity were reported. Polar organic extracts: methanol, ethanol and acetone of L. feei presented considerable levels of phenols and flavonoids. These levels were ranged from 127.07 to 262.11 mg GAE/g and 84 to 157.88 mg CEQ/g, respectively. Considerable antioxidant activity of polar organic extracts of L. feei was revealed. In the DPPH scavenging method, methanolic extract expressed an IC50 of about 3.2 μg/mL which is comparable to that of the ascorbic acid (2.48 μg/mL). The same extract expressed strong antioxidant power against hydroxyl radical with an IC50 of about 36.33 μg/mL, which is higher than that of the ascorbic acid (61.83 μg/mL). In the test of the β-carotene bleaching, acetone extract expressed a remarkable antioxidant power comparable to the positive control (IC50: 5.85 μg/mL and 4.26 μg/mL, respectively). A low cytotoxic activity against human red blood cells was exerced by the methanol extract of L. feei, this could explaine the safety uses of this plant by indigenous populations.
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Faiza Mouderas,Imad Abdelhamid El Haci,Farid Boucif Lahfa 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.3
The aim of this study was to investigate for the frst time the antioxidant and the antimicrobial activities of organic extracts from Traganum nudatum Delile using in vitro models. The extracts which exhibited the highest activities were then submitted to RP-HPLC–PDA analysis. The phytochemical screening revealed the presence of favonoids, tannins, alkaloids, saponins and quinones. The highest amounts of polyphenols, favonoids and favonols were recorded in ethyl acetate fractions. The strongest DPPH scavenging ability was attributed to ethyl acetate fraction of crude extract prepared by maceration EAFM with IC50 value of 20±0.11 µg/mL, ethyl acetate fraction of crude extract prepared by infusion EAFI was found to possess the highest ferric reducing power with EC50 of 35±0.4 µg/mL. The highest antioxidant capacity 200.21±0.2 mg AAE/g was exhibited by n-butanol fraction of crude extract prepared by maceration BFM. The antimicrobial activity was proven against all the tested microorganisms except on Candida albicans strains. The extracts were more active on Gram positive than Gram negative bacteria. The strongest inhibition was provided against Bacillus subtilis, Bacillus cereus and Listeria monocytogenes. The identifcation of phenolic compounds using RP-HPLC–PDA technique revealed the presence of sinapic, syringic, ferulic, p-coumaric acids, catechin, naringenin and vanillin that may be responsible for the bioactivities of the reported specie. Our results indicate that T. nudatum Delile may provide a rich and novel source of natural antioxidants for industrial utilization replacing synthetic ones.
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Karima Belarbi,Fawzia Atik-Bekkara,Imad Abdelhamid El Haci,Ilhem Bensaid,Fawzia Beddou,Chahrazed Bekhechi 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.2
Teucrium pseudo-Scorodonia Desf., is one of many Mediterranean plants widely used in Algerian folk medicine for their medicinal properties. This study represents the first antioxidant investigation of Teucrium pseudo-Scorodonia with different analytical methods. Total phenolic, flavonoid, and condensed tannin contents were determined using spectrophotometric techniques. In vitro antioxidant and radical scavenging profiling was determined through total antioxidant capacity (TAC), DPPH radical-scavenging, ferric reducing antioxidant power (FRAP), and β-carotene bleaching assays. Leaf extracts exhibited high total phenolics (266.36 ± 0.14 mg GAE/g DW), flavonoids (161.23 ± 0.18 mg CE/g DW) and condensed tannins (5.00 ± 0.08 mg CE/g DW) contents. The greatest antioxidant activity was founding in the butanolic fraction of leaves (IC50.DPPH = 0.05 ± 0.00 mg/ml) followed by crude methanolic extract and ethyl acetate fraction. These values were to some extent high in comparison to the positive control (0.07 ± 0.01 mg/ml). The same tendency was observed with ferric reducing power. A strong correlation of IC50 values of antioxidant assays with total phenolics and total flavonoids content of T. pseudo-Scorodonia was exhibited in this study. Thin layer chromatographic (TLC) screening using DPPH radical, AlCl3 and FeCl3 as detection reagents led to the identification of potent antioxidant compounds: methylated flavonoids or hydroxyflavonols. These results indicate that flavonoids and phenolics can be the major contributors to the antioxidant activity observed for the T. pseudo-Scorodonia leaf extracts. Further study is necessary for isolation and characterization of the active antioxidants, which may serve as a potential source of natural antioxidants.
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Ilhem Bensaid,Fawzia Atik Bekkara,Imad Abdelhamid El Haci,Karima Belarbi,Fawzia Beddou,Chahrazed Bekhechi 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4
The valorization of the local flora is the goal of the laboratory of Natural Products from the University of Tlemcen (Algeria). In this work, we report the scientific study of a medicinal plant Cynoglossum cheirifolium L. The crude methanol and tannin extracts of C. cheirifolium were preliminary analyzed for their phenolic contents (total phenolics, total flavonoids and total tannins). These extracts were evaluated for their antioxidant properties using different methods. The results showed that crude methanolic extract of the leaves part revealed high phenolic (134.93 ± 9.76 mg Gallic Acid Equivalent/g Dry Weigth), flavonoid (99.99 ± 0.72 mg Catechin Equivalent/g Dry Weigth) and condensed tannin contents (1.65 ± 0.05 mg Catechin Equivalent/g Dry Weigth). Furthermore, the results obtained from the study of the antioxidant activity showed that tannin extract of stems displayed the highest DPPH• scavenging ability with the inhibition concentration of 50% (IC50) value of 70 ± 1 μg/mL, it was comparable to the Vitamin E with an IC50 value of 60 ± 1 μg/mL. The vitamin E concentration required to reduce the ferric iron was lower (242 ± 6 μg/mL) than tannins extracted from leaves (214 ± 4 μg/mL). Hence, using an RP-HPLC-PDA (Reverse Phase-High Pressure Liquid Chromatography-PhotoDiode Array Detector) analysis, it was possible to identify phenolic acids and flavonoid like rutin; naringenin; rosmarinic acid; sinapic acid; p-coumaric acid; ferulic acid; caffeic acid and syringic acid.
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