鷄肉의 筋原纖維 Type에 따른 Myosin의 加熱 젤 形成能에 관한 연구

崔一信 안성산업대학교 1995 論文集 Vol.27 No.-

Myosins were prepared from both chicken leg and breast muscles to examine the reason for differences in the heat-induced gel stengths of these myosins at high ionic strength and low pH. In summary, the results showed that the heat-induced gel strength of breast myosin began to increase at pH 5.8 but that observed with leg myosin did not increased at that pH, although it was higher than that of breast myosin below pH 5.6. The viscosity of breast myosin increased as the pH decreased between pH 5.5 and pH 5.8, although that of leg myosins decreased. At pH 5.7, leg and breast myosins assembled to form short filaments before heating. Both myosins formed longer filament at pH 5.4, although breast myosins tended to form longer ones. These reaults indicate that the differences in filamentogenesis and heat-induced gelation of myosins from chicken leg and breast muscle myosins at high ionic strength and low pH may be to related to those in thermogelation of each myosin.

안면거상술(Face Lift)을 이용한 안면노화(Aging face) 치험례(319례)

최 준,신명수,김동일,이영준,백세민,오재욱 大韓成形外科學會 1992 Archives of Plastic Surgery Vol.19 No.6

There are some differences between Orientals and Caucasians in the amount and type of aging. In general, Orientals have thicker facial skin with more subcutaneous adipose tissues than Caucasians. These differences result in characteristic Oriental aging face combined with round and flat facial contours. Many surgical techniques of face lift or rhytidectomy have been largely performed in Caucasians, but less in Orientals, therefore, we should consider modified principles and techniques in the surgery of the oriental aging face. First, postoperative incision scars are more prominent in Orientals than in Caucasians and this calls for a modified incision design n oriental patients. Second, wide dissection is mandatory for a good result because the skin is very thick and less pliable in oriental patients. Third, it is not necessary to perform cervicofacial platysmal surgery in most cases of oriental face lift. We experienced 171 cases of oriental patients with aging faces and performed 319face lifting procedures during recent 3 years(from Mar. 1988 to Feb. 1991). Combined procedures such as suction lipectomy, forehead augmentation, blepharoplasty, and facial bone contouring surgery were performed simultaneously case by case. Types of anesthesia were decided according to the psychologic states and wishes of patients and the types of combined procedures. Thirty-five cases of 171 patients(20.5%) were performed under local anesthesia. Subcutaneous forehead lifts with ultrasobic vibrator-dissection were our new interesting trials with good results. Complications were 11 cases of wound hematoma(6.4%) and 3 cases of focal wound dehiscence(1.8%). The patients with the complications were completely recovered 6 months later.

Factors Determining Children's Private Health Insurance Enrolment and Healthcare Utilization Patterns: Evidence From the 2008 to 2011 Health Panel Data

Shin, Jawoon,Lee, Tae-Jin,Cho, Sung-il,Choe, Seung Ah The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.6

Objectives: Parental socioeconomic status (SES) exerts a substantial influence on children's health. The purpose of this study was to examine factors determining children's private health insurance (PHI) enrolment and children's healthcare utilization according to PHI coverage. Methods: Korea Health Panel data from 2011 (n=3085) was used to explore the factors determining PHI enrolment in children younger than 15 years of age. A logit model contained health status and SES variables for both children and parents. A fixed effects model identified factors influencing healthcare utilization in children aged 10 years or younger, using 2008 to 2011 panel data (n=9084). Results: The factors determining children's PHI enrolment included children's age and sex and parents' educational status, employment status, and household income quintile. PHI exerted a significant effect on outpatient cost, inpatient cost, and number of admissions. Number of outpatient visits and total length of stay were not affected by PHI status. The interaction between PHI and age group increased outpatient cost significantly. Conclusions: Children's PHI enrolment was influenced by parents' SES, while healthcare utilization was affected by health and disability status. Therefore, the results of this study suggest disparities in healthcare utilization according to PHI enrollment.

Retrospective Analysis on 76 Cases of Cerebral Arteriovenous Malformations Treated by Gamma Knife Radiosurgery

Choe, Jae-Gyun,Im, Yong-Seok,Kim, Jong-Soo,Hong, Seung-Chyul,Shin, Hyung-Jin,Lee, Jung-Il The Korean Neurosurgical Society 2008 Journal of Korean neurosurgical society Vol.43 No.6

Objective : Outcome of gamma knife radiosurgery (GKS) in the consecutive 100 cases with cerebral arteriovenous malformations (AVMs) was analyzed. Methods : Data from initial 100 patients treated with GKS in the authors' institute were reviewed retrospectively. Spetzler-Martin grade at diagnosis were I in 18 patients, II in 27, III in 36, IV in 11, and V in 8. Thirty-five patients had experienced previous bleeding, 27 patients presented with seizure, and 31 patients presented with headache. The mean volume of the lesion was $4.3\;cm^3\;(0.1-29.3\;cm^3)$. The median radiation dose delivered to the margin was 20.0Gy (13-32Gy). Mean follow-up period was 37.5 months (5-63 months). Results : Angiographic follow-up was performed in 48 patients at least 2 years after GKS. Sixteen patients were lost in follow up following 2 years from GKS. Twenty-eight of 48 patients (58%) showed complete obliteration and 20 patients (42%) showed partial obliteration. Seven patients presented with post-GKS hemorrhage. Adverse radiation effect (ARE) was observed at follow-up MRI in 25 of 76 patients, and it was symptomatic in 5 patients. Complete obliteration was confirmed in 24 of 31 (77%) patients with volume less than $4\;cm^3$, meanwhile only 4 of 17 (24%) patients with volume of $4\;cm^3$ or more showed complete obliteration. Complete obliteration rate was 67% with 20Gy or higher marginal dose, 63% with 15-20 Gy, and 17% with less than 15Gy. Conclusion : GKS can provide high rates of obliteration with acceptable risk of morbidity in a subgroup of small AVMs. However, overall outcome in whole spectrum of AVMs, in which large proportion of cases have unfavorable characteristics for radiosurgery, is much worse. More effective therapeutic strategy needs to be developed for large AVMs that are difficult to be managed with current available treatment modalities.

A Study on Acupuncture-generated Blood- Oxygen-Level Dependant Signals in Substantia Nigra and Other Areas in Extrapyramidal Tract

Choe Il-hwan,Park Hi-joon,Yoon Hyo-woon,Shin Hyung-chul,Lee Sang-hoon,Lee Yun-ho,Lim Sabina 대한침구의학회 2008 대한침구의학회지 Vol.25 No.1

목적 : 전통적으로 태충(LR3)과 양릉천(GB34)은 운동기능과 관련된 질환에 사용되어 왔다. 우리는 두뇌에 신경독을 주입하여 파킨슨병 쥐모델을 제작하였고, 쥐는 운동기능이 손상되고 도파민성 신경세포가 선택적으로 소멸하였다. 병증 모델 쥐에게 태충과 양릉천에 자침한 결과 운동기능이 개선되고 신경세포보호효과가 나타남을 관찰한 바 있다. 이에 실제로 태충과 양릉천에 자침하여 운동기능과 관련된 추체외로 영역에서 신경의 활성화가 나타나는지를 fMRI를 통하여 관찰하였다. 방법 : 자침은 수기침을 선택하였으며, 혈위는 ① 태충, ② 양릉천, ③ 태충+양릉천의 세군데를 설정하였고, 자침에 대한 대조자극으로 피부자극을 채택하였다. fMRI 스캐너는 3T를 사용하였고 뇌신경 활성화의 신호는 BOLD(blood-oxygen-level dependant)를 관찰하였다. 두뇌에서 관찰부위는 중뇌를 중심으로 추체외로로 한정하였다. 결과 : 태충에 자침하였을 때 두뇌의 substantia nigra, subthalamic nucleus, red nucleus, pons 등이 활성화 되었다. 양릉천에 자침하였을 때 substantia nigra, subthalamic nucleus, caudate nucleus, thalamus가 활성화 되었다. 태충과 양릉천에 동시에 자침하였을 때는 substantia nigra, subthalamic nucleus, red nucleus, globus pallidus가 활성화되었다. 대조자극에 의해서는 위의 영역들이 활성화되지 않았다. 결론 : 태충, 양릉천, 태충+양릉천 자극은 대뇌에서 추체외로 영역을 활성화시키며 특히 substantia nigra의 활성화는 파킨슨병과 같은 질환의 조절가능성을 시사한다.

친환경 대공간 건축물의 바이오필릭 디자인

최동일(Choe, Dong il),박강근(Park, Kang Geun),신상화(Shin, Sang Hwa) 한국주거환경학회 2019 주거환경(한국주거환경학회논문집) Vol.17 No.2

This paper proposes large space buildings which applied a eco-friendly biophilic design. The biophilic architecture is to consider the building design for nature-friendly environment, nature-inspired concepts, healing facilities, the coexistence, inter-relationship and balance of human and nature. The consideration of architecture and urban design is to create an eco-friendly environment that has good feelings through the interaction of nature and human being. The inner and outer spaces of buildings are designed to be part of nature according to the changes of time and season, and feel the emotional stability and comfort through nature-friendly design. The biophilic design is try to create a healing environment for the harmony and balance of mental health which is the coexistence of nature. The biophilia is the attempt to translate an understanding of a human affinity to affiliate with healing environment into the design of architecture, and is based on the assertion that humans have inter-connections with nature. Nature-inspired design in the space is to introduce the incorporation of plants, flowers, trees, daylight and water into buildings. Natural analogues are to apply a biomorphic forms and patterns, natural materials, and natural systems. Nature-inspired space is to introduce different spatial configurations for view prospect, protected spaces, wind path, and obscured features. This paper will be proposed large spatial domes applying biophilic architectural design for the harmony of between nature and human life. The proposed large space dome is a structure that can protect human beings and provide a more pleasant environment due to extreme environment and air pollution.

Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis

김민교,Choe Yongho,Lee Heewon,Jeon Min-Gyu,Park Jin-Ho,Noh Hae Sook,천윤홍,박희진,Park Jaehun,Shin Sung Jae,Lee Kyunglim,Lee Sang-Il 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) stimulates cancer progression and allergic responses, but the role of HRF/TCTP in rheumatoid arthritis (RA) remains undefined. In this study, we explored the pathogenic significance of HRF/TCTP and evaluated the therapeutic effects of HRF/TCTP blockade in RA. HRF/TCTP transgenic (TG) and knockdown (KD) mice with collagen-induced arthritis (CIA) were used to determine the experimental phenotypes of RA. HRF/TCTP levels in the sera of RA patients were measured and compared to those from patients with osteoarthritis (OA), ankylosing spondylitis, Behçet’s disease, and healthy controls. HRF/TCTP expression was also assessed in the synovium and fibroblast-like synoviocytes (FLSs) obtained from RA or OA patients. Finally, we assessed the effects of HRF/TCTP and dimerized HRF/TCTP-binding peptide-2 (dTBP2), an HRF/TCTP inhibitor, in RA-FLSs and CIA mice. Our clinical, radiological, histological, and biochemical analyses indicate that inflammatory responses and joint destruction were increased in HRF/TCTP TG mice and decreased in KD mice compared to wild-type littermates. HRF/TCTP levels in the sera, synovial fluid, synovium, and FLSs were higher in patients with RA than in control groups. Serum levels of HRF/TCTP correlated well with RA disease activity. The tumor-like aggressiveness of RA-FLSs was exacerbated by HRF/TCTP stimulation and ameliorated by dTBP2 treatment. dTBP2 exerted protective and therapeutic effects in CIA mice and had no detrimental effects in a murine tuberculosis model. Our results indicate that HRF/TCTP is a novel biomarker and therapeutic target for the diagnosis and treatment of RA.

Clinical characteristics according to CAT score level in COPD patients: cross-sectional study

( Hyun-il Gil ),( Sungmin Zo ),( Jiyeon Kang ),( Noeul Kang ),( Hyunkyu Cho ),( Yeonseok Choi ),( Junsu Choe ),( Hye Yun Park ),( Sun Hye Shin ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Purpose: Chronic obstructive pulmonary disease (COPD) assessment test (CAT) is widely used to measure quality of life in COPD. This tool is also one of determinants of COPD severity to guide COPD management. This study aimed to investigate the clinical characteristics of COPD patients according to CAT score level measured at baseline. Method: COPD patients with CAT score measured at baseline were retrospectively identified from COPD registry of Samsung Medical Center between February 2016 and April 2019. COPD was defined as post-bronchodilator forced expiratory volume in 1 second (FEV1)/ forced vital capacity (FVC) < 0.7 and age ≥ 40 years. Patients were grouped into quintiles of CAT score level. Baseline clinical characteristics and lung function parameters were compared according to CAT score quintiles. Result: A total of 725 patients were included and median (interquartile range [IQR]) CAT score was 17 (11 - 24). Median (IQR) of each CAT score quintile were 6 (4 - 8), 13 (11 - 14), 18 (17 - 19), 23 (22 - 25), and 30 (28 - 34). Age, sex, smoking history and Charlson comorbidity index score did not differ according to CAT score quintiles. Dyspnea of modified medical research council (mMRC) grade ≥ 2 and the previous history of any exacerbation significantly increased across CAT score quintiles, while post bronchodilator FEV1 and diffusing capacity of lung for carbon monoxide (DLco) significantly decreased across CAT score quintiles. Conclusion: Among the clinical characteristics of COPD patients, dyspnea, previous history of any exacerbation, post bronchodilator FEV1 and DLco were significantly associated with CAT score level.

Relining technique for continuous sac enlargement and modular disconnection secondary to endotension after endovascular aortic aneurysm repair

Moon Il Lee,Woo Young Shin,Yun Mee Choe,Jae Young Park,Jang Yong Kim,Yong Sun Jeon,Soon Gu Cho,Kee Chun Hong 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.3

Endotension is an unpredictable late complication of endovascular aortic aneurysm repair (EVAR). This case report will discuss the successful treatment of enlarged aneurysmal sac due to endotension using the relining technique. An 81-year-old male complained of nondecreasing huge aneurysm sac. He had undergone EVAR for infrarenal abdominal aortic aneurysm 7 years prior and no endoleak was found through follow-up. Initially computed tomography-guided sac aspiration was tried, but in vain, Relining using the double barrel technique and tubular endograft for modular diconnection, which was unexpectedly found in the original endograft, were performed sucessfully. During follow-up after the relining procedure, the size of aneurysm sac continued to decrease in size. The relining technique is effective mothod for treating endotension.

Fabrication and characteristics of P-channel silicon-oxide-nitride-oxide-silicon flash memory device based on bulk fin shaped field effect transistor structure

Cho, Il Hwan,Park, Tai-Su,Choe, Jeong Dong,Cho, Hye Jin,Park, Donggun,Shin, Hyungcheol,Park, Byung-Gook,Lee, Jong Duk,Lee, Jong-Ho American Vacuum Society 2006 JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B - Vol.24 No.3