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Behc¸et의 患者의 單球細胞에서 溫淸飮의 cytokine 分泌抑制 효과
임홍진,황충연,강학천,김남권,권일호 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.4
Behc¸ets disease is a systemic inflammatory disorder. The etiology and pathogenesis of Behc¸ets disease has yet been fully elucidated but might involve immune dysfunction. Cytokines involved in the regulation of inflammatory reactions and immune responses may play a role in the pathogenesis of Behc¸ets disease (BD). Onchungeum is an Oriental herbal medication, which has been successfully used in Korea for the treatment of BD. This report describes modulation effects of Onchungeum on cytokine production from phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) of Behc¸ets patients by ELISA. Onchungeum significantly inhibited the production of pro-inflammatory cytokines, TNF-α and IL-1β, compared to absence of Onchungeum (by 52.3 1.4% inhibition for TNF-α and 113.5 3.3% for IL-1β, p < 0.001). Onchungeum also inhibited the production of IFN-γ, immunoregulatory Th1 cytokine, by 89.4 0.8% (p < 0.001). The inhibitory effects of Onchungeum on cytokine production showed dose-dependent manner, and the pre-treatment of 1㎎/㎖ Onchungeum had better effects than immunosuppressive drug for treatment of BD, cyclosporin A. Our results suggest that Onchungeum treatment for Behc¸ets disease patients may have pharmacologic activities and abilities of regulation of immune and inflammatory responses by cytokine modulation.
오연희,이창욱,김승현,이성우,정병욱,이준희,박동일,권영무,신현종 동국대학교 경주대학 1996 東國論集 Vol.15 No.-
Morgagni 탈장은 횡격막의 전내측 부위의 발달이상으로 열공을 통하여 장관이나 대망과 같은 복강내 구조물이 흉곽내로 빠져나가는 드문 질환으로 알려져 있다. 저자들은 호흡곤란을 주소로 내원하여 방사선학적 검사와 수술로 확진된 1례를 보고한다. Morgagni hernia is improperly located abdominal viscera into the thoracic cavity through the foramen of Morgagni which is a congenital defect at the anterornedial portion of diaphragm. We report a case of Morgagni hernia diagnosed by radiologic examination and operation.
전승정,김태헌,류민선,오다연,송명은,이신아,류재인,김혜인,문일환,유권 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2
The causes of pyogenic liver abscess has been known as biliary tract disease or intrabadominal infection but the large proportions of the patients has no apparent underlying disorders. Recently colonic mucosal lesions were reported in patients with cryptogenic liver abscess and it has been suggested that colonic mucosal break may play a role in developing liver abscess in otherwise healthy patients. We experienced a patient of severe recurrent liver abscess complicated with endophthalmitis only 3 months after successful treatment of initial cryptogenic liver abscess and a polypoid colon cancer was discovered by chance. It seems prudent to proceed colonoscopic examination in patients with cryptogenic liver abscess especially when it is recurrent.
육안적 혈뇨로 내원한 환자에서 발견된 방광 유전분증 : 증례보고
김은진;성 현;홍수민;정성연;박경식;손형래;박일권;구호석;고행일 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-
Amyloidosis is a disease resulting in deposition of amyloid in the body. The disease can be either primary or secondary. The amyloidosis of urinary bladder is more usually affected by primary amyloidosis and also very rare. The patient with primary amyloidosis of the bladder usually presents with gross hematuria. The amyloidosis resembles bladder cancer in cystoscopy. It can be confirmed by biopsy. The treatment consists of medication (e.g., steroid, antitumor agent, cholchicine, DMSO) and/or transurethral resection. The standard treatment is mephalan and prednisolone. A 49-year-old man complained of recently developed gross hematuria without abdominal pain. We examined urinary bladder cystoscope for gross hematuria. It revealed small bulging mass on trigone are a of bladder. Therefore we did bladder biopsy. Finally, it revealed bladder amyloidosis. The patient was improved by medication (mephalan 2mg and prednisolone 1 mg/kg po daily). We report an unusual case of amyloidosis involving bladder.
손형규,하달봉,박동일,오연희,권순훤 동국대학교 경주대학 1996 東國論集 Vol.15 No.-
요도결석은 대개 방광결석에 의해 생기며 드물게 원발성으로 요도에서 발견된다. 원발성 요도결석은 남성에 있어서는 요도협착, 요도게실, 이전의 요도 및 전립선수술과, 여성의 경우 거의 대부분 요도게실과 관계가 있다. 요도결석은 신체검사, 내시경검사 및 방사선학적 검사를 통해 진단하여 치료시 결석의 치료뿐 아니라 기존 질환의 진단 및 치료를 병행하여야 한다. 저자들은 급성 요폐로 내원한 55세 남자환자에서 신체검사 및 요도 내시경검사를 통해 거대 구부요도결석으로 진단한 후 관혈적 요도결석제거술로 치유하였기에 문헌고찰과 함께 보고하는 바이다. Urethral stone may from primarily in the urethra or may migrate from the bladder or upper urinary tract. Primary urethral calculi usually are associated with chronic stasis and infection. Virtually all urethral stone in women have been found in a urethral diveniculum. The diagnosis may be confirmed by palpation, endoscopic visualizatlon, or radiographic study. Treatment should be directed by the underlying cause. Herein, we reported a case of giant bulbous urethral stone in 55-year-old men, with a brief review of literature. Key Words: Stone, Bulbous urethra.
IL-Kwon Park,Junheon Kim,Yeon-Suk Lee,Sang-Gil Lee,Sang-Chul Shin 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.05
Plant essential oils from twenty plant species were tested for their insecticidal activity against larvae of Lycoriella ingenua using a fumigation bioassay. Good insecticidal activity (>90%) against larvae of L. ingenua was achieved with essential oils of caraway seed (Carum carvi), lemongrass (Cymbopogon citratus), mandarine (Citrus reticulate), nutmeg (Myristica fragrans), cade (Juniperus oxycedrus), spearmint (Mentha spicata), cumin (Cuminum cyminum) and thyme red (Thymus vulgaris) oils at 30×10-3 mg/㎖ air. Among them, caraway seed, spearmint, cumin and thyme red essential oils were highly effective against L. ingenua at 20×10-3 mg/㎖ air. Analysis by gas chromatography-mass spectrometry led to identification of 4, 9, 8 and 17 compounds from caraway seed, spearmint, cumin and thyme red oils, respectively. These compounds were tested individually for their insecticidal activities against larvae of L. ingenua, and compared to the toxicity of dichlorvos. Carvacrol, thymol, linalool, cuminaldehyde, p-cymen, terpinen-4-ol and carvone was effective at 10×10-3 mg/㎖. The insecticidal activity of dichlorvos was 60% at 10×10-3 mg/㎖. Effects of four selected plant essential oils on growth of Pleurotus ostreatus were also investigated.
Soon-IL Kim,Sung Hum Yeon,Jae Won Kwon,Hee Sung Yoon,Young Joon Ahn 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10
The larvicidal activity of materials from Ostericum koreanum (Apiaceae) root against late 3rd or early 4th instar larvae of Aedes aegypti and Culex pipiens pallens was examined using standard WHO technique under laboratory conditions. Results were compared with those of temephos. The biologically active constituents of O. koreanum root were characterized as four coumarines; isoimperatorin (I), osthol (II), oxypeucedanin (III) and imperatorin (IV) by spectroscopic analysis, including EI-MS, LC-MS, 1H NMR and 13C NMR spectroscopy. On the basis of 24-hr LC50 values, osthol among these four coumarines was the most toxic against Ae. aegypti (1.97 ppm) and Cx. pipiens pallens (1.87 ppm) larvae, but its activity was less than temephos (0.0047 and 0.013 ppm, respectively). LC50 values of isoimperatorin, oxypeucedanin and imperatorin derived from O. koreanum root against Ae. aegypti larvae were 2.46, 6.92 and 2.17 ppm, and against Cx. pipiens pallens larvae, were 1.99, 5.04 and 3.68 ppm. The results indicate that both materials and coumarines from O. koreanum root have potential to be used for mosquito control.
경량 동적콘관입시험기를 이용한 화강풍화토의 다짐도에 따른 역학특성
김연일(Yeon-Il Kim),김진영(Jin-Young Kim),심재록(Jae-Rok Shim),최진(Jin Choi),강권수(Kwon-Soo Kang),백원진(Won-Jin Baek),이강일(Kang-Il Lee) 한국지반신소재학회 2014 한국지반신소재학회 논문집 Vol.13 No.3
본 연구에서는 남원 사면현장에서 채취된 화강풍화토를 이용하여 경량 동적콘관입시험기의 국내 사면현장에서 적용성을 조사하였다. 그리고 다짐도와 함수비 변화에 따른 경량 동적콘관입시험을 수행하고, 다짐도, 간극비, 포화도와 콘관입 저항치와의 상관성을 분석하였다. 그 결과로 최적함수비의 건조측에서 함수비 증가와 더불어 관입저항치가 급격히 증가하고 습윤측에서 크게 감소하는 경향을 나타내었다. 또한 물리적 특성과의 상관관계에서 다짐도 및 포화도가 클수록 콘 저항치가 선형적으로 증가하는 것을 확인하였다. 이로 인해 역학특성 변화에 따른 함수비, 간극비, 포화도와 콘관입저항치 사이에 높은 상관성을 보여 사면조사시 경량 동적콘관입시험기의 현장적용이 가능할 것으로 판단된다. In this study, the applicability of the lightweight dynamic cone penetrometer in the domestic slope site was investigated using the weathered granite soil sampled form the Namwon slope site. And then, the lightweight dynamic cone penetration tests according to the change in the degree of compaction and water content were performed and it was analyzed with the correlations between the degree of compaction, the void ratio, the degree of saturation and the value of cone resistance. From the laboratory test results, the cone penetration resistance was rapidly increased in the dry side of the optimum moisture content, and it was largely decreased in the wet side of the optimum moisture content. Moreover, when the degree of compaction and the degree of saturation are large, the cone resistance is increased linearly. And a high correlativity was shown between water content, void ratio, the degree of saturation and the cone resistance. From these results, it is judged that the lightweight dynamic cone penetrometer can be applied to the investigation on the site slope.