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Direct Access to Various 1-Substituted-imidazo[1,5-a]pyridine-3(2H)-thione Derivatives.
Kim, Ikyon,Lee, Ge Hyeoung,No, Zae Sung WILEY-VCH Verlag 2007 Chem Inform Vol.38 No.34
<P>ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.</P>
Twist Boat Conformation of Thiane S-Oxide Both in Solid State and in Solution
Jeon, Dong-Ju,Kim, Ikyon Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.7
A stable twist boat conformation of thiane S-oxide 1a in solid state and in solution was unambiguously determined by single crystal X-ray crystallography and solution NMR analyses. On the contrary, the thiane Sdioxide 2 which was obtained from the oxidation of corresponding thiane S-oxide 1a was confirmed to adopt a regular chair conformation.
Twist Boat Conformation of Thiane S-Oxide Both in Solid State and in Solution
Dong Ju Jeon,Ikyon Kim 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.7
A stable twist boat conformation of thiane S-oxide 1a in solid state and in solution was unambiguously determined by single crystal X-ray crystallography and solution NMR analyses. On the contrary, the thiane Sdioxide 2 which was obtained from the oxidation of corresponding thiane S-oxide 1a was confirmed to adopt a regular chair conformation.
Convergent synthesis of diptoindonesin G
Singh, Dileep Kumar,Kim, Ikyon Elsevier 2019 Tetrahedron letters: the international organ for t Vol.60 No.3
<P><B>Abstract</B></P> <P>A convergent and scalable synthetic route to a tetracyclic oligostilbenoid natural product, diptoindonesin G, is described where Suzuki-Miyaura cross-coupling and intramolecular Friedel-Crafts acylation were employed to construct the central C ring of diptoindonesin G. Two fragments for cross-coupling reaction were readily synthesized with similar efficiency.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A convergent and scalable synthetic approach to diptoindonesin G is described. </LI> <LI> Suzuki-Miyaura coupling and intramolecular Friedel-Crafts acylation as key steps. </LI> <LI> This route should be useful for synthesis of diptoindonesin G and its derivatives. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Skeletal Reorganization: Synthesis of Diptoindonesin G from Pauciflorol F
Singh, Dileep Kumar,Kim, Ikyon American Chemical Society 2018 Journal of organic chemistry Vol.83 No.3
<P>Described herein is a novel synthetic approach to diptoindonesin G, a highly potent anticancer oligostilbenoid natural product, from pauciflorol F pentamethyl ether through a skeletal reorganization strategy where oxidative cleavage of the indanone ring system of pauciflorol F and sequential cyclization of the key intermediate allowed direct access to the target skeleton.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2018/joceah.2018.83.issue-3/acs.joc.7b03089/production/images/medium/jo-2017-03089y_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jo7b03089'>ACS Electronic Supporting Info</A></P>
Nayak, Maloy,Kim, Ikyon American Chemical Society 2015 Journal of organic chemistry Vol.80 No.22
<P>A highly convergent synthetic approach to rotenoid natural products is described. Successful pairing of two building blocks for Sonogashira cross-coupling and intramolecular alkyne carbonyl metathesis allows ready access to 4-acylchromene, a key substructure of these natural products, leading to syntheses of (±)-deguelin and (±)-munduserone in high overall yields.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2015/joceah.2015.80.issue-22/acs.joc.5b02160/production/images/medium/jo-2015-02160k_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jo5b02160'>ACS Electronic Supporting Info</A></P>
Deformylative Intramolecular Hydroarylation: Synthesis of Benzo[<i>e</i>]pyrido[1,2-<i>a</i>]indoles
Jung, Youngeun,Kim, Ikyon American Chemical Society 2015 ORGANIC LETTERS Vol.17 No.18
<P>Attempted cyclization of indolizines bearing both formyl and alkyne groups under acid catalysis provided benzo[<I>e</I>]pyrido[1,2-<I>a</I>]indoles with an aryl substituent at the C6 position as major products, along with the expected C5-acylated benzo[<I>e</I>]pyrido[1,2-<I>a</I>]indoles as minor ones, which resulted from preferential deformylative intramolecular hydroarylation instead of intended alkyne-carbonyl metathesis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2015/orlef7.2015.17.issue-18/acs.orglett.5b02331/production/images/medium/ol-2015-02331m_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol5b02331'>ACS Electronic Supporting Info</A></P>
Dong Ju Jeon,Ikyon Kim,Sun Gi Kim,,Young-Lan Hyun 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.8
The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.
Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation
( Won Serk Kim ),( Ikyon Kim ),( Wang Kyun Kim ),( Ju Yeon Choi ),( Doo Yeong Kim ),( Sung Guk Moon ),( Hyung Keun Min ),( Min Kyu Song ),( Jong Hyuk Sung ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.3
Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.