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The Role of Leptin in the Association between Obesity and Psoriasis
( Jaehyeon Hwang ),( Ju Ah Yoo ),( Hyungkee Yoon ),( Taekyung Han ),( Jongchan Yoon ),( Seoljun An ),( Jae Youl Cho ),( Jongsung Lee ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.1
Adipose tissue secretes many adipokines which contribute to various metabolic processes, such as blood pressure, glucose homeostasis, inflammation and angiogenesis. The biology of adipose tissue in an obese individual is abnormally altered in a manner that increases the body’s vulnerability to immune diseases, such as psoriasis. Psoriasis is considered a chronic inflammatory skin disease which is closely associated with being overweight and obese. Additionally, secretion of leptin, a type of adipokine, increases dependently on adipose cell size and adipose accumulation. Likewise, high leptin levels also aggravate obesity via development of leptin resistance, suggesting that leptin and obesity are closely related. Leptin induction in psoriatic patients is mainly driven by the interleukin (IL)-23/helper T (Th) 17 axis pathway. Furthermore, leptin can have an effect on various types of immune cells such as T cells and dendritic cells. Here, we discuss the relationship between obesity and leptin expression as well as the linkage between effect of leptin on immune cells and psoriasis progression.
지열 발전을 위한 HFC-245fa 유기 랭킨 사이클의 성능해석
백영진(YoungJin Baik),김민성(Minsung Kim),장기창(KiChang Chang),윤형기(HyungKee Yoon),이영수(YoungSoo Lee),나호상(HoSang Ra) 한국지열·수열에너지학회 2009 한국지열에너지학회논문집 Vol.5 No.1
In this study, an ORC (Organic Rankine Cycle) is investigated for a low-temperature geothermal power generation by a simulation method. A steady-state simulation model is developed to analyze cycle's performance. The model contains a turbine, a pump, an expansion valve and heat exchangers. The turbine and pump are modelled by an isentropic efficiency. Simulations were carried out for the given heat source and sink inlet temperatures, and given flow rate that is based on the typical power plant thermal-capacitance-rate ratio. HFC-245fa is considered as a working fluid of the cycle. Simulation results, at the given secondary working fluids conditions, show that even though the power can be presented by both the evaporating temperature and the turbine inlet superheat, it depends on the evaporating temperature primarily.