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정형일(Hyungil Jung),김정동(Jung Dong Kim),김미루(Mi-roo Kim),마니타 당골(Manita Dangol) 한국생물공학회 2010 KSBB Journal Vol.25 No.6
Vaccine is a protective clinical measure capable of persuading immune system against infectious agents. Vaccine can be categorized as live attenuated and inactivated. Live attenuated vaccines activate immunity similar to natural infection by replicating living organisms whereas inactivated vaccines are either whole cell vaccines, eliciting immune response by killed organisms,or subunit vaccines, stimulating immunity by non-replicating sub cellular parts. The components of vaccine play a critical role in deciding the immune response mediated by the vaccine. The innate immune responds against the antigen component. Adjuvants represent an importantcomponent of vaccine for enhancing the immunogenicity of the antigens. Subunit vaccines with isolated fractions of killed and recombinant antigens are mostly co-administered with adjuvants. The delivery system of the vaccine is another essential component to ensurethat vaccine is delivered to the right target with right dosage form. Furthermore, vaccine delivery system ensures that the desired immune response is achieved by manipulating the optimal interaction of vaccine and adjuvantwith the immune cell. The aforementioned components along with routes of administration of vaccine are the key elements of a successful vaccination procedure. Vaccines can be administered either orally or by parenteral routes. Many groups had made remarkable efforts for the development of new vaccine and delivery system. The emergence of new vaccine delivery system may lead to pursue the immunization goals with better clinical practices.
Dissolving Microneedles for Pharmaceutical Drug Delivery
정형일 ( Hyungil Jung ) 한국피부장벽학회 2018 한국피부장벽학회지 Vol.20 No.2
Dissolving microneedles are referred to micro-scale needles that are capable of delivering pharmaceutical compounds, proteins and other large biomolecules into the skin in a minimally invasive manner. These microneedles depending on their matrix backbone structure may take from seconds to hours to dissolve, providing fast or sustained release functionalities. Based on recent researches, achievement of a highly efficient delivery has become possible via dissolving microneedles and it is expected that microneedles would replace the widely used hypodermic needles in the near future. Also dissolving microneedles have various potentials, the activity of encapsulated compounds can be significantly reduced during fabrication process. Therefore, we have evaluated and optimized dissolving microneedle fabrication factors by which activity of encapsulated compounds including lysozyme, exendin-4, etc. can be highly maintained throughout the fabrication process. We have also developed dissolving microneedles capable of delivering valproic acid which showed a higher efficiency compared with topical application. Overall, our focus is on developing new methods to overcome the limitations of traditional microneedle systems through novel technologies.