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RISS 인기검색어
- 검색키워드
- 저자 : Hyosang Lee (검색결과 96 건)
- 무료
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- 유료
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Estimation of flexible needle deflection in layered soft tissues with different elastic moduli.
Lee, Hyosang,Kim, Jung P. Peregrinus Ltd.] 2014 Medical & biological engineering & computing Vol.52 No.9
<P>The estimation of needle deflection when the needle interacts with biological tissue is challenging in needle steering. Most previous studies have used homogeneous tissue models to estimate the deflection of a needle. However, biological tissue typically has a layered structure with variable mechanical properties and geometric features. In this study, we propose a needle deflection model with a double-layered elastic medium. Each layer possesses distinct mechanical properties, which result in inconsistent degrees of friction force on the needle surface, needle-cutting force, and forces caused by the stiffness of the elastic medium. The model uses the Rayleigh-Ritz method to analytically estimate the needle deflection. To validate the model, needle steering experiments were performed using double-layered tissue phantoms and porcine tissues. The experimental results revealed that changes in reaction force at the needle base occurred when the needle passed through the boundary between the two layers. The mean absolute error between the estimated and measured needle tip trajectory was 0.88??0.30?mm for the double-layered tissue phantom and 1.85??0.73?mm for the porcine tissue. These results are comparable with previous studies of homogeneous tissue. The proposed model could improve needle steering in biological tissues, which consist of multiple layers.</P>
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Development of a Pad Conditioning Method for ILD CMP using a High Pressure Micro Jet System
Hyosang Lee,Darren DeNardis,Ara Philipossian,Yoshiyuki Seike,Mineo Takaoka,Keiji Miyachi,Toshiro Doi 한국전기전자재료학회 2007 Transactions on Electrical and Electronic Material Vol.8 No.1
The goal of this study is to determine if High Pressure Micro Jet (HPMJ) conditioning can be used as a substitute for, or in conjunction with, conventional diamond pad conditioning. Five conditioning methods were studied during which 50 ILD wafers were polished successively in a 100-mm scaled polisher and removal rate (RR), coefficient of friction (COF), pad flattening ratio (PFR) and scanning electron microscopy (SEM) measurements were obtained. Results indicated that PFR increased rapidly, and COF and removal rate decreased significantly, when conditioning was not employed. With diamond conditioning, both removal rate and COF were stable from wafer to wafer, and low PFR values were observed. SEM images indicated that clean grooves could be achieved by HPMJ pad conditioning, suggesting that HPMJ may have the potential to reduce micro scratches and defects caused by slurry abrasive particle residues inside grooves. Regardless of different pad conditioning methods, a linear correlation was observed between temperature, COF and removal rate, while an inverse relationship was seen between COF and PFR.
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Lee, Hyosang,Kim, Ui Chul,Oh, Jae Keun,Kim, Taehyun,Park, Sohee,Ha, Yoon The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.1
Objective : This study is a retrospective cost-benefit analysis of cervical anterior interbody fusion and cervical artificial disc replacement, which are the main surgical methods to treat degenerative cervical disc disease. Methods : We analyzed 156 patients who underwent anterior cervical disc fusion and cervical artificial disc replacement from January 1, 2008 to December 31, 2009, diagnosed with degenerative cervical disc disorder. In this study, the costs and benefits were analyzed by using quality adjusted life year (QALY) as the outcome index for patients undergoing surgery, and a Markov model was used for the analysis. Only direct medical costs were included in the analysis; indirect medical costs were excluded. Data were analyzed with TreeAge Pro $2015^{TM}$ (TreeAge Software, Inc, Williamstown, MA, USA). Results : Patients who underwent cervical anterior fusion had a total cost of KRW 2501807/USD 2357 over 5 years and obtained a utility of 3.72 QALY. Patients who underwent cervical artificial disc replacement received 4.18 QALY for a total of KRW 3685949/USD 3473 over 5 years. The cumulative cost-effectiveness ratio of cervical spine replacement surgery was KRW 2549511/QALY (USD 2402/QALY), which was lower than the general Korean payment standard. Conclusion : Both cervical anterior fusion and cervical artificial disc replacement are cost-effective treatments for patients with degenerative cervical disc disease. Cervical artificial disc replacement may be an effective alternative to obtain more benefits.
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Thermal, Tribological, and Removal Rate Characteristics of Pad Conditioning in Copper CMP
Hyosang Lee,Darren DeNardis,Ara Philipossian,Yoshiyuki Seike,Mineo Takaoka,Keiji Miyachi,Shoichi Furukawa,Akio Terada,Yun Zhuang,Len Borucki 한국전기전자재료학회 2007 Transactions on Electrical and Electronic Material Vol.8 No.2
High Pressure Micro Jet (HPMJ) pad conditioning system was investigated as an alternative to diamond disc conditioning in copper CMP. A series of comparative 50-wafer marathon runs were conducted at constant wafer pressure and sliding velocity using Rohm & Haas IC1000 and Asahi-Kasei EMD Corporation (UNIPAD) concentrically grooved pads under ex-situ diamond conditioning or HPMJ conditioning. SEM images indicated that fibrous surface was restored using UNIPAD pads under both diamond and HPMJ conditioning. With IC1000 pads, asperities on the surface were significantly collapsed. This was believed to be due to differences in pad wear rates for the two conditioning methods. COF and removal rate were stable from wafer to wafer using both diamond and HPMJ conditioning when UNIPAD pads were used. Also, HPMJ conditioning showed higher COF and removal rate when compared to diamond conditioning for UNIPAD. On the other hand, COF and removal rates for IC1000 pads decreased significantly under HPMJ conditioning. Regardless of pad conditioning method adopted and the type of pad used, linear correlation was observed between temperature and COF, and removal rate and COF.
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Study of Inhibition Characteristics of Slurry Additives inCopper CMP using Force Spectroscopy
Hyosang Lee,Ara Philipossian,Suryadevara V. Babu,Udaya B. Patri,Youngki Hong,Laertis Economikos,Michael Goldstein 한국전기전자재료학회 2007 Transactions on Electrical and Electronic Material Vol.8 No.1
Using a reference slurry, ammonium dodecyl sulfate (ADS), an anionic and environmentally friendly surfactant, was investigated as an alternative to BTA for its inhibition and lubrication characteristics. Results demonstrated that the inhibition efficiency of ADS was superior to that of BTA. Coefficient of friction (COF) was the lowest when the slurry contained ADS. This suggested that adsorbed ADS on the surface provided lubricating action thereby reducing the wear between the contacting surfaces. Temperature results were consistent with the COF and removal rate data. ADS showed the lowest temperature rise again confirming the softening effect of the adsorbed surfactant layer and less energy dissipation due to friction. Spectral analysis of shear force showed that increasing the pad-wafer sliding velocity at constant wafer pressure shifted the high frequency spectral peaks to lower frequencies while increasing the variance of the frictional force. Addition of ADS reduced the fluctuating component of the shear force and the extent of the pre-existing stick-slip phenomena caused by the kinematics of the process and collision event between pad asperities with the wafer. By contrast, in the case of BTA, there were no such observed benefits but instead undesirable effects were seen at some polishing conditions. This work underscored the importance of real-time force spectroscopy in elucidating the adsorption, lubrication and inhibition of additives in slurries in CMP.
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Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus
Lee, Jae Seung,Kweon, Hae-Jin,Lee, Hyosang,Suh, Byung-Chang The Rockefeller University Press 2019 The Journal of general physiology Vol.151 No.7
<P>Acid-sensing ion channels (ASICs) are voltage-independent cation channels that are modulated by extracellular pH fluctuations. Lee et al. identify three neutral residues in the N terminus (T25, T39, and I40) that are critical for rapid resensitization of homomeric and heteromeric ASIC2a channels.</P><P>Acid-sensing ion channels (ASICs), sensory molecules that continuously monitor the concentration of extracellular protons and initiate diverse intracellular responses through an influx of cations, are assembled from six subtypes that can differentially combine to form various trimeric channel complexes and elicit unique electrophysiological responses. For instance, homomeric ASIC1a channels have been shown to exhibit prolonged desensitization, and acid-evoked currents become smaller when the channels are repeatedly activated by extracellular protons, whereas homomeric or heteromeric ASIC2a channels continue to respond to repetitive acidic stimuli without exhibiting such desensitization. Although previous studies have provided evidence that both the desensitization of ASIC1a and rapid resensitization of ASIC2a commonly require domains that include the N terminus and the first transmembrane region of these channels, the biophysical basis of channel gating at the amino acid level has not been clearly determined. Here, we confirm that domain-swapping mutations replacing the N terminus of ASIC2a with that of ASIC2b result in de novo prolonged desensitization in homomeric channels following activation by extracellular protons. Such desensitization of chimeric ASIC2a mutants is due neither to internalization nor to degradation of the channel proteins. We use site-directed mutagenesis to narrow down the relevant portion of the N terminus of ASIC2a, identifying three amino acid residues within the N terminus (T25, T39, and I40) whose mutation is sufficient to phenocopy the desensitization exhibited by the chimeric mutants. A similar desensitization is observed in heteromeric ASICs containing the mutant subunit. These results suggest that T25, T39, and I40 of ASIC2a are key residues determining the rapid resensitization of homomeric and heteromeric ASIC2a channels upon proton activation.</P>
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Lee, Hyosang,Cho, Haedo,Kim, Sangjoon J,Kim, Yeongjin,Kim, Jung Institute of Physics Publishing 2018 Smart materials & structures Vol.27 No.2
<P>Recently, piezo-resistive nanocomposites have emerged as an important smart material for realizing less obtrusive and more comfortable stretch sensing applications. To manufacture cost-effective and skin-mountable stretch sensor, dispenser printing is advantageous method because piezo-resistive nanocomposites can be directly printed on a woven elastic fabric in various patterns. However, both electrical and mechanical properties of the nanocomposites need to be modulated to achieve favorable sensing performance as well as strong adhesion between the nanocomposite and the fabric to sustain large strains. Moreover, inherent hysteretic behavior of the soft nanocomposite should be compensated to obtain consistent stretch sensing. This paper presents silicone rubber mixed with long multi-walled carbon nanotubes (Long-MWCNTs) composites as a piezo-resistive transducing material for dispenser printing. High aspect ratio of the Long-MWCNTs resulted in low viscosity of a liquid state nanocomposite and high electrical conductivity. Due to the low viscosity, the liquid state nanocomposite could permeate into gaps of the woven elastic fabrics and ensured strong bonding force in large strains up to 35%. In addition, a modified Prandtl-Ishilinskii (MPI) model was adopted to compensate for piezo-resistive hysteresis of the nanocomposite. For validation, the skin-mountable sensor was applied to estimate rotation angle of a wrist. The sensor system estimated the rotation angle of the wrist with an estimation error of 1.93 degrees within 65 degrees range (2.9%) for the step increment and decrement test, and 7.15 degrees within 75 degrees range (9.5%) for the arbitrary movement test. Thus, the experimental results show that the dispenser printing method incorporated with hysteresis compensation can provide a guideline to implement skin-mountable smart fabrics for stretch sensing using various nanocomposites</P>
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