Phellinus baumii 자실체 열수 추출물의 Sarcoma-180에 대한 항암 및 면역효과

하효철 외 한국버섯학회 2004 한국버섯학회지 Vol.2 No.4

국내에서 재배되고 있는 약용버섯인 상황(P. baumii) 자실체의 열수 추출물로 부터 건강 기능성 식품 및 의약품개발의 기초자료를 제공하고자 항암실험 및 면역효과에 대한 실험을 수행하였다. 본 연구에서 사용한 PMO-P4의 경우 rDNA의 ITS부위의 염기서열 분석을 통한 계통분석 결과 P. baumii로 판명 되었으며, PMO-P4 자실체로부터 열수 추출한 성분(HWE-P4)을 160mg/kg/day의 농도로 하여 Sarcoma-180 암세포를 유발한 마우스에 경구투여한 결과 A군의 경우, 종양억제효과는 35.3%로 대조군보다 유의성 있게 감소하였으며(p<0.05), 생명연장 효과는 156%증가한 것으로 나타났다. 시료의 경구투여 방법에 있어서도 시료를 먼저 2주간 투여한 후 암세포를 접종한 A군의 경우가 시료 투여와 암세포 접종을 동시에 실시한 B군의 경우 보다 종양억제효과 및 생명연장효과가 높았음을 알 수 있었다. A군의 경우 대조군에 비하여 CD4/CD8의 비율이 71.4%증가 하였으며, CD25(IL-2receptor chain)분자의 발현을 5배정도 증가시키는 것으로 관찰되었다. 이러한 결과로 보아 P. baumii로 밝혀진 PMO-P4 자실체로부터 열수 추출한 성분의 항암효과는 암세포를 직접 공격하여 항암효과를 나타내기 보다는 T cell등의 면역세포를 활성화시킴으로써 암세포를 억제 혹은 사멸시키는 것으로 생각된다. A hot water extract(HWE-P4) was separated from the fruit bodies of PMO-P4, and its antitumor and immunomodulatory activities against sarcoma-180 in ICR mice were investigated. The internal transcribed spacer(ITS) regions from PMO-P4 were amplified using polymerase chain reaction(PCR) and sequenced. The results revealed that PMO-P4 was belong to the Phellinus baumii. When oral administration at the dose of 160mg/kg/day in the mice until the end of the experiment with 2 week's pre-feeding of the HWE-P4, the survival rate of the mice was 152% for 50days after the inoculation of sarcoma-180 and the suppression rate of the tumor growth was 35.3%(p<0.05) for 28 days after inoculation of sarcoma-180. The HWE-P4 increased 71.4% of the CD4/CD8 ratio and 5-fold of the expression of CD25(IL-2 receptor chain) compared with the control. From these results, the antitumor activity of HWE-P4 is exerted through its immunomodulating activity on the host's immune system.

DCT 주파수 영역의 범위 값에 대한 연구

김효철 啓明專門大學 産業開發硏究所 2002 啓明硏究論叢 Vol.20 No.1

본 논문에서는 영상압축의 표준으로 널리 사용되고 있는 JPEG에서 채택하고 있는 8×8 부 블록의 이산여현변환(DCT : Discrete Cosine Transform) 값의 주파수 영역을 대상으로 영상의 성질을 분석하였다. 이 과정에서 표준 영상 중 복잡도가 서로 다른 영상들을 표본으로 사용하였으며, 64개 계수값 중에서 5개를 선택하였고 영상의 성질을 대표하기 위한 수단으로 선택된 계수 값들의 범위값을 사용하였다. This paper covers image property analysis using frequency band of 8×8 sub-block DCT values in JPEG as standard of image compression. The proposed method uses different complexity sample images among standard images and selects 5 coefficients from 64 items. The range value of selected coefficients is adopted as parameter for image property.

해밀튼적 최대 평면 그래프의 4색 가능성 연구

李宗哲,金孝喆 慶北大學校 1988 論文集 Vol.46 No.-

Several properties of Hamiltonian Maximal Planar Graphs are discussed, including the degree-sequences that are embeddable as HMPG, the number of 4-colour instances of HMPG, and the relation with comdlete 4-partite graphs.

치과용 자성 어태치먼트 재료의 안정성 개선에 관한 연구 : II.질화티타늄 코팅이 치과용 자성재의 내식성에 미치는 영향 Ⅱ.Effect of TiN Coating on Corrosion Resistance of Dental Magnetic Materials

최한철,고영무,정재헌,신종연,김일선,최성욱,정효수 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.4

Dental magnetic materials have been applied to removable prosthetic appliances, maxillofacial prostheses, obturator and dental implant but they still have some problems such as low corrosion resistance in oral environments. To increase the corrosion resistance of dental magnetic materials, surfaces of Sm-Co and Nd-Fe-B based magnetic materials were plated with TiN and then electrochemical corrosion test were performed in 4 kinds of electrolyte solutions(0.9% NaCl. 1% lactic acid, 0.05% HCl and modified Fusayama's artificial saliva). From this study, corrosion behavior, amount of elements released, mean average surface roughness values and the changing of mean surface microhardness values were measured comparing with control group of non-sputtered plating magnetic materials. The results were as follows: 1. TiN layer coated on magnet grows into preferred direction with lamellar structure and its thickness is 3.0㎛. 2. Sm-Co base magnetic materials coated with TiN have good corrosion resistance in 1% lactic acid and their pitting corrosion can not be seen. 3. Nd-Fe-B base magnetic materials coated with TiN showed good tendency of corrosion resistance in 0.05% HCl solution. 4. The amount of elements released from both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were more significantly decreased than that of uncoated magnetic materials. 5. The mean surface roughness values of both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were smooth than that of uncoated magnetic materials after corrosion test. 6. The decreasing rate of microhardness of both Sm-Co and Nd-Fe-B base magnetic materials coated with TiN were lower than that of uncoated magnetic materials after corrosion test. 7. Dental magnetic materials coated with TiN produced various corrosion products such as TiO, TiO₂, Ti₂O₃on the surface and resulted in better corrosion resistance than uncoated magnetic materials. In conclusion, it is considered that the corrosion problem of dental magnetic materials could be solved to some extent by EB-PVD with TiN on the surface of dental magnetic materials.

중학교 수학에서의 대수개�牟�대한 이해와 적용에 관한 연구 : 중학교 3학년을 중심으로 For the third grade of middle school

朴順喆,朴孝精 조선대학교 사범대학 부설 교과교육연구소 1999 敎科敎育硏究 Vol.2 No.1

시차주사열량분석기를 이용한 치과용 접착시멘트의 경화기전 및 반응열에 관한 연구

김철위,이용근,윤태호,김효종,남세진 大韓齒科器材學會 2000 대한치과재료학회지 Vol.27 No.3

The working time of dental cement has a close relation with the setting time, where the setting reaction can be said as the result of the chemical reaction between cement liquid and powder. The purpose of this experiment was to investigate the setting characteristics and setting rate of dental cements by measuring the exothermic heat(Joule/gram) from the setting reaction at specified times using a differential scanning calorimeter (Differential Scanning Calorimeter, DSC 204, TASC 414/3A Controller, Netzche, Germany). Graphs of time-exothermic heat at 37℃ isothermal condition, showing the setting reaction of dental cements were plotted. Three types of luting cements studied were zinc-phosphate cement (ZPC), polycarboxylate cement (PCC), and glass ionomer cement (GIC). The effects of powder-liquid ratio on the setting characteristics of cements were also included. The amount of heat (calory) released per one gram of cement was calculated at each specified time, and was analyzed. ANOVA and Scheff's multiple comparison test (p=0.05) were used for statistical analysis using SPSS/PC+. The setting rate of cement was not constant during the setting reaction, and different setting characteristics were observed depending on the type of cement and powder/liquid ratio. Generally, 70∼90% of the setting reaction, measured by the exothermic heat release, occurred within 5 minutes after mixing. The exothermic heat released by ZPC was very high immediately after mixing, and the duration of the heat release was prolonged compared with other cements. The exothermic heat release of PCC finished most rapidly. It was generally observed that the amount of heat release (rise in temperature) per one gram of cement was highest for ZPC, followed by GIC, and then PCC. However, heat release during the first 2∼5 minutes after mixing was highest for GIC, followed by ZPC and then PCC. According to the Scheff's multiple comparison test, the duration of the total setting reaction did not show any significant difference among the cements(p>0.05), and also among the different power/liquid ratio groups(p>0.05). It was observed that more heat was released with the lower powder/liquid ratio than the higher powder/liquid ratio.

압출용 다이스의 Melt-고분자 열유동 기초연구

정효희,김재열,최진호,유신,윤성운,홍철,김종문 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

As importance part of extruder, hopper(Hopper) been raw material supply wealth, main frame that screw and barrel that transformation of supply raw material attains are because deformed raw material is fearful finally extrusion to done dies attain. Extruder is divided by greatly above 3 but hopper has assembled in dehumidification of raw material and supply of smooth raw material, and make in Melt state as raw material is stabilized because main frame consists of screw and barrel and Melt does anaphora as done material is stabilized. And dies that is last part between barrel with screw anaphora done Melt material as is stabilized without causing change that is much depending on anaphora of screw from dies way out as correct product produce make to. In this treatise, make anaphora can present ideal dies basis design using CFdesign that is heat & flow analysis programs so that can produce detailed product through pipe channel flow analysis of stable dies applying anaphora value of do polymer raw material in Screw.

기업의 기부·접대비 지출행위에 관한 연구

홍효석,김동훈,박용철 진주산업대학교 1999 산업과학기술연구소보 Vol.- No.6

This study is to analyze the relation factors of corporate contribution and entertainment expenses. We try to seek to find out the motives of corporate contributions and entertainment expense for describing factors. Previous study is reported different result for our study. Then this study reexamines about this more analytical approach. We select 2,062 sample firms during 1991-1996 and result using correlation analysis is as follows. Contribution and entertainment expense shows a significantly positive with firm size that is corporate sales except for 1991. The contribution and entertainment expense has a significant positive relation with cash flow, industry contribution level, pre-period contribution level, advertisement, research and development cost, effective tax rate, retained earnings. In the case of debt ratio, the result shows significantly negative relation. Therefore we assert that the contribution and entertainment expenses are made for earnings management.

구강악안면 외상환자의 조직손상의 양상 및 정도에 관한 임상적 연구

신효근,소병수,안태섭,진우성,윤철희 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3

This is a clinical and retropective study on th patients with oral and maxillofacial trauma. This study was based on a series of 917 patients were treated as in-patients, at Chon-buk National University Hospital, during the period of Jan., 1989 through Dec., 1993. The results obtained were as follows : 1. The ratio of men to women were 3.59 : 1 in oral and maxillofacial injuries, 3.92 : 1 in facial bone fractures, and 3.18 : 1 in soft tissue injuries. 2. The oral and maxillofacial injuries occurred most frequently in the third decade(32.2%), and fourth, second, fifth decade in orders. 3. The major etiologic factors were traffic accident(57.4%) and fall-down(17.1%), interpersonal accident(16.6%), and industrial accident were next in order of frequency. 4. The incidence of facial bone fracture was 72.1%, soft tissue injury 58.8%, and dental injury 40.5%. 5. The most common site of fracture were mandible(62.9%) and maxilla(19.9%), zygoma and zygomatic arch(18.7%), and nasal bone(4.7%) were next in order of frequency. 6. The most common type of soft tissue injury was laceration(51.0%). The lesion of soft tissue injuries were mostly 1 or 2 lesions and deep.

인터넷을 이용한 환자감시장치의 개발

김효철 啓明專門大學 産業開發硏究所 2000 啓明硏究論叢 Vol.18 No.2

본 논문은 환자감시장치에 사용되는 소프트웨어의 구현에 대한 내용이다. 환자감시장치는 환자에 부착된 각종 센서로부터 여러 종류의 생체신호를 측정하고 이를 처리, 분석하여 환자의 상태정보를 추출하여 의료진에게 출력해 주는 장치이다. 현재 이러한 제품들은 많이 출시되어 있지만 이를 인터넷에 연동시켜 공간상의 제약을 제거하는 것이 이 분야의 최대 관심거리가 되고 있다. 본 연구의 주안점은 인터넷을 이용하여 환자의 상태를 감시할 수 있고 실시간 데이터베이스 기술을 이용하여 최근 24시간 동안의 최근 환자 상태에 대한 막대한 정보를 저장하여 분석이 가능하도록 한 것이다. 이 연구의 결과는 원격 의료분야의 기반으로 사용될 수 있을 것이다. This paper covers implemention of PMS(Patient Monitoring System) software. PMS is used for observation of patient s organic signals from various kinds of sensors. And, It is used for management, analysis information of patient's condition. In the long run, these medical appliances offer the information to supervisor. Today, the hot issue of this field is interlink to Internet. Main topics of this research are interlinking and realtime database technology. Employment of realtime database technology is able to store a large quantity of 24 hours organic signals, and analyze it. The fruits of this research can be used for foundation of remote medical treatment.