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허혜경,이은현,이원희,소향숙,정복례,강은실 성인간호학회 2002 성인간호학회지 Vol.14 No.3
Purpose: This study was to investigate symptom occurrence related to the disease characteristics of patients with cancer. Method: A total of 301 patients with cancer participated in this study. The participants were recruited from University Hospitals located in Seoul, Wonju, Kwangju, Daegu, and Pusan. Data collection was performed by using a questionnaire on symptom occurrence. The obtained data was analyzed using SPSS computer program that included descriptive statistics, Pearson correlation, one-way ANOVA, and t-test. Result: The mean score of fatigue was the highest (3.24), followed by loss of appetite, lack of concentration, change in appearance, pain, insomnia, change in bowel pattern, nausea/vomiting, coughing, and dyspnea. Most symptoms were significantly correlated with each other. The level of symptom occurrence in patients with lung cancer or cervix cancer was significantly higher than the level in patients with stomach cancer. Patients receiving radiation therapy or a combined therapy of radiation therapy and chemotherapy experienced significantly higher level of symptom occurrence significantly higher level of symptom occurrence than those receiving chemotherapy only. Also, female patients experienced higher level of symptom occurrence than male patients did. Conclusion: The sites of cancer, types of treatment, and gender influence the level of symptom occurrence of patients with cancer. Thus, these variables should be considered when assessing and planing for symptom occurrence of patients with cancer.
초음파 탐촉자(Probes)의 위생관리 실태와 감염 인식도 조사 및 세균 오염도 측정
김창복(Chang Bok Lee),이양섭(Yang Sub Lee),이원홍(Won Hong Lee),조정찬(Cheong Chan Cho),윤향이(Hyang Yi Yoon),이용문(Yong Moon Lee),김영근(Young Keun Kim),이경섭(Kyung Sup Lee) 대한방사선과학회(구 대한방사선기술학회) 2004 방사선기술과학 Vol.27 No.3
The gel, which is stained on probe after ultrasonogmphy, is a good circumstances for proliferation of microbe. This study is to investigate into the actual state of sanitary management, recognition degree and infection level of ultrasonographic probes. We had performed a question with telephone to 42 hospitals in Seoul area from December in 2003. We also cultured to obtained a sample from three ultrasonographic units to investigate infection level of the probes. Sanita교 management of the probes was performed in 21 hospitals with alcohol cotton, Sanitary management was performed daily in 14 hospitals. Most hospitals used cotton towel for clearing of gel stained on probes. Preventive management against infection was performed in 32 hospitals with vinyl cover, surgical glove, or alcohol sterilization etc. In the recognition degree on infection, the response that using method of ultrasonographic probes is insanitary were in 78.6%(33 hospitals), and 54.8%(23 hospitals) responded that bacteria can be infected through the probes. In the results of germiculture, bacteria and fungi were detected too number of to count, but escherichia coli was not detected. In conclusion, The gel stained on probe after ultrasonography must be cleared completely, and it is necessary that change of reco후ition on sanitary management. 초음파 검사 후 완전히 제거되지 않고 남아있는 Gel은 미생물이 증식하기에 좋은 조건을 가지고 있다. 따라서 본 연구자들은 초음파 탐촉자의 위생관리 실태와 위생과 감염에 대한 인식의 정도를 알아보기 위해서 2003년 12월부터 서울지역에 있는 42개의 병원을 대상으로 전화설문을 시행하였다. 또한 세 대의 초음파 장치 탐촉자에서 시료를 채취하여 미생물을 배양 증식한 후 탐촉자의 오염된 정도를 알아보았다. 21개 병원만이 탐촉자의 위생관리를 실시하였고, 소독 방법은 주로 알콜솜을 많이 이용하였다. 위생관리 주기는 14개 병원만이 매일 하는 것으로 조사되었다. 탐촉자에 묻은 Gel제거 방법은 면수건을 많이 이용 하였다. 감염의 위험에 노출되어 있는 환자의 초음파 검사 시 감염예방관리를 하고 있는 병원은 32개였고 환자 검사 시 탐촉자를 비닐커버나 외과용 장갑, 알콜 소독 후 사용하고 있는 것으로 조사되었다. 감염 인식도 조사에서 초음파 탐촉자 사용법이 비위생적이라는 생각이 78.6%(33개)였고, 탐촉자를 통한 세균이 감염여부에 대해 54,8%(23개)가 감염될 수 있을 것으로 생각하고 있었다. 탐촉자에서 채취한 시료를 배양 한 결과 세균과 진균이 셀 수 없이 너무 많이 오염되어 있었고 대장균은 검출되지 않았다. 결론적으로 초음파 검사 후에는 탐촉자에 묻어있는 Gel에서 세균이 증식하여 감염이 될 수 있으므로 완전히 제거하여 환자간 교차 감염의 위험요인을 줄이는 것과 감염관리에 대한 의식전환이 필요하다고 생각된다.
Lee, Jong-Ho,Kim, Na-Hyang,Winstel, Volker,Kurokawa, Kenji,Larsen, Jesper,An, Jang-Hyun,Khan, Adnan,Seong, Min-Young,Lee, Min Ja,Andersen, Paal Skytt,Peschel, Andreas,Lee, Bok Luel American Society for Microbiology 2015 Infection and immunity Vol.83 No.11
<P>The cell envelopes of many Gram-positive bacteria contain wall teichoic acids (WTAs). <I>Staphylococcus aureus</I> WTAs are composed of ribitol phosphate (RboP) or glycerol phosphate (GroP) backbones substituted with <SMALL>d</SMALL>-alanine and <I>N</I>-acetyl-<SMALL>d</SMALL>-glucosamine (GlcNAc) or <I>N</I>-acetyl-<SMALL>d</SMALL>-galactosamine (GalNAc). Two WTA glycosyltransferases, TarM and TarS, are responsible for modifying the RboP WTA with α-GlcNAc and β-GlcNAc, respectively. We recently reported that purified human serum anti-WTA IgG specifically recognizes β-GlcNAc of the staphylococcal RboP WTA and then facilitates complement C3 deposition and opsonophagocytosis of <I>S. aureus</I> laboratory strains. This prompted us to examine whether anti-WTA IgG can induce C3 deposition on a diverse set of clinical <I>S. aureus</I> isolates. To this end, we compared anti-WTA IgG-mediated C3 deposition and opsonophagocytosis abilities using 13 different staphylococcal strains. Of note, the majority of <I>S. aureus</I> strains tested was recognized by anti-WTA IgG, resulting in C3 deposition and opsonophagocytosis. A minority of strains was not recognized by anti-WTA IgG, which correlated with either extensive capsule production or an alteration in the WTA glycosylation pattern. Our results demonstrate that the presence of WTAs with TarS-mediated glycosylation with β-GlcNAc in clinically isolated <I>S. aureus</I> strains is an important factor for induction of anti-WTA IgG-mediated C3 deposition and opsonophagocytosis.</P>
이향복 ( Hyang-bok Lee ),이행병 ( Haeng Byoung Lee ),이처영 ( Cheo Young Lee ),김은기 ( Eun-ki Kim ) 대한화장품학회 2007 대한화장품학회지 Vol.33 No.4
멜라닌은 UV로부터 피부를 보호하는 기능을 하며, 인종과 피부색을 결정하는 요인이다. 또한 미백 기능성 화장품개발의 주요 목표물이기도 하다. 최근 미와 관련된 화장품 시장이 급성장 하면서 미백효능 증대를 위한 연구들이 활발히 진행되고 있고, 보다 안전하고 효능을 극대화하기 위한 미백 기성화장품의 개발은 관심업계의 주력 분야이다. 또한 경쟁력을 확보하기 위한 수단으로 지속적인 특허 출원이 따르고 있다. 특허는 관련업계의 연구경향을 파악할 수 있는 중요한 문헌이기도 하다. 본 논문에서는 미백 기능성화장품과 관련된 특허 분석을 통하여 관련 업계의 미백연구기술의 개발 동향을 소개하고 미백 기능성 화장품의 개발 및 활성성분의 원료개발에 대한 이해를 돕고자 한다. Melanin plays an important role in protecting human skin from UV radiation and determines the race and skin color. Melanin is also major target for developing skin-whitening cosmeceuticals. Recently, as the market size of skin-whitening cosmeceuticals has rapidly expanded, related researches and developments are also focused on maximizing the safety and efficacy. Also, patents of skin-whitening materials have been increasing steadily for ensuring the competitive power. Patent also shows the research trend of industry and institutes. In this review, we analyze the trend of research and development based on the patent application of skin-whitening cosmeceuticals.
KU, Bok-Kyung,KIM, Soon-Bok,MOON, Oun-Kyeong,LEE, Sang-Jin,LEE, Jong-Hwan,LYOO, Young-Soo,KIM, Hee-Jung,SUR, Jung-Hyang Japanese Society of Veterinary Science 2005 The Journal of veterinary medical science Vol.67 No.11
<P>In this study, we performed experiments to evaluate the extend of the process of apoptotic cell death by foot-and-mouth disease virus (FMDV). Apoptosis can also occur in some virus-infected cells, and ability of viruses to either inhibit or promote apoptosis may influence the pathologic outcome of infection. In this study, to determine if apoptosis plays a role in the outcome of FMDV infection in swine, we evaluated apoptosis in diseased tissues collected from pigs inoculated with two different stains of FMDV (O1 Campos and O Taiwan). And host cell DNA fragmentation in diseased tissue from animals which were infected with either virus was evaluated by occurrence of a laddering pattern characteristic of apoptosis. Infection of cultured keratinocytes from swine tongue failed to demonstrate apoptosis in the first few hours of infection, suggesting that cell-to-cell correlation between viral antigen and apoptotic changes, e.g. cytokine secretions by immune system cells, could be critical to initiating apoptosis. Consistent with this finding, we were able to detect the pro-inflammatory cytokine TNF-α in diseased tissues. A clear difference in the pathogenicity of the two different FMDV isolates to pigs was not demonstrated in our study.</P>