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Jian Shi,Huichai Yang,Xiaoyang Duan,Lihua Li,Lulu Sun,Qian Li,Junjun Zhang 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.3
Purpose: The present study aimed to investigate the value of apolipoproteins, including ApoA-1, ApoC-III, and ApoE, in patients with small cell lung cancer (SCLC) as potential biomarkers for diagnosis, prognosis, and cancer progression. Materials and Methods: Lung samples were collected from 89 patients with SCLC. Nineteen lung samples from non-small cell lung cancer (NSCLC) patients and 12 normal lung tissues were used as controls. Expression profiles of ApoA-1, ApoC-III, and ApoE in different samples were examined using immunohistochemical methods, and the expression levels were correlated with cancer types, treatment, and outcomes using chi-square and Mann-Whitney tests. Results: Expression of ApoA-1 and ApoC-III in SCLC was significantly different, compared with that in NSCLC and normal lung tissues, and was correlated with recurrence of SCLC. Patients undergoing neoadjuvant chemotherapy before surgery showed significantlyreduced expression of ApoA-1 and increased expression of ApoC-III and ApoE. Nevertheless, the expression levels of ApoA-1, ApoC-III, and ApoE were not correlated with SCLC staging. Conclusion: ApoA-1 and ApoC-III may be used as differentiating and predictive markers for SCLC. ApoA-1, ApoC-III, and ApoE may be used to monitor the efficacy of chemotherapy.
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Hui Chai,Waheed Ur Rehman,Xuyun Yang,Tao Meng,Renyang He 한국섬유공학회 2022 Fibers and polymers Vol.23 No.10
To improve the wear resistance of friction components coated with epoxy resin, a titanium-multi-walled carbonnanotubes (Ti-MWCNT) reinforced epoxy resin composite coating was designed and prepared by combining metalnanoparticles and inorganic nanoparticles into a hybrid filler using Ti nanoparticles and MWCNT as raw materials. Thechanges in functional groups of pure resin and Ti-MWCNT reinforced epoxy resin composites were analyzed using infraredspectroscopy. The hardness, fracture toughness and tribological properties of pure resin and Ti-MWCNT-reinforced epoxyresin composite coatings with different contents of Ti-MWCNT filler (0, 2 wt.%, 4 wt.%, 6 wt.%, 8 wt.%) were determinedexperimentally. The fracture and wear mechanisms of Ti-MWCNT-reinforced epoxy resin composites were also revealedwith the aid of scanning electron microscopy. The results showed that the bonding form of Ti-MWCNT hybrid filler andepoxy resin was physical bonding. The addition of appropriate amount of Ti-MWCNT hybrid filler effectively improved thehardness, fracture toughness and tribological properties of epoxy resin. When 6 wt.% Ti-MWCNT hybrid filler was added,the optimum composite was obtained with hardness and fracture toughness of 676 HL and 0.922 MPa·m1/2, and frictioncoefficient and wear rate of 0.347 and 4.71×10-13 m3(N·m)-1, respectively. However, the performance of the compositecoating gradually decreased when the filler content was increased to 8 wt.%. In summary, the addition of appropriate amountof Ti-MWCNT hybrid filler can effectively improve the hardness, fracture toughness and tribological properties of epoxyresin. Ti nanoparticles react chemically with oxygen and effectively fill the microcracks generated in the resin matrix. TheMWCNT filler limits the movement of the surrounding resin matrix due to the difference in size and prolongs the diffusionpath of the microcracks in the resin matrix. The interaction between the two filler components significantly improves theperformance of the composite coating.
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