http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
miR-215 Enhances HCV Replication by Targeting TRIM22 and Inactivating NF-κB Signaling
Hui Tian,Zhenkun He 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.4
Purpose: Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associatedwith HCV infection. This study aimed to investigate the functional roles and possible molecular mechanisms of miR-215 in HCVreplication. Materials and Methods: The expression levels of miR-215 and TRIM22 were detected by quantitative real-time PCR (qRT-PCR)and western blot analysis in Con1b subgenomic genotype 1b HCV replicon cells (Con1b cells) and JFH1 full genome infectingHuh7.5.1 cells (Huh7.5.1 cells). HCV RNA levels were measured by qRT-PCR. The protein levels of NS3, NS5A, p65 subunit of NF-κB (p65), and phosphorylated p65 (p-p65) were determined by western blot analysis. The relationship between miR-215 andTRIM22 were explored by target prediction and luciferase reporter analysis. Results: miR-215 overexpression enhanced HCV replication in Con1b cells, while miR-215 knockdown suppressed HCV replicationin Huh7.5.1 cells. TRIM22 was confirmed to be a direct target of miR-215. TRIM22 upregulation resulted in a decline in HCVreplication, while TRIM22 inhibition led to enhancement of HCV replication. Additionally, exogenous expression of TRIM22 reversedthe facilitating effect of miR-215 on HCV replication, while TRIM22 downregulation counteracted the inhibitory effect ofmiR-215 knockdown on HCV replication. Furthermore, miR-215 targeted TRIM22 to block the NF-κB pathway, and exerted apositively regulatory role on HCV replication. Conclusion: miR-215 facilitated HCV replication via inactivation of the NF-κB pathway by inhibiting TRIM22, providing a novelpotential target for HCV infection.
A Flexible Network Access Scheme for M2M Communications in Heterogeneous Wireless Networks
( Hui Tian ),( Wei Xie ),( Youyun Xu ),( Kui Xu ),( Peng Han ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.10
In this paper, we deal with the problem of M2M gateways` network selection for different types of M2M traffic in heterogeneous wireless networks. Based on the difference in traffic`s quality of service (QoS) requirements, the M2M traffic produced by various applications is mainly classified as two categories: flexible traffic and rigid traffic. Then, game theory is adopted to solve the problem of network-channel selection with the coexistence of flexible and rigid traffic, named as flexible network access (FNA). We prove the formulated discrete game is a potential game. The existence and feasibility of the Nash equilibrium (NE) of the proposed game are also analyzed. Then, an iterative algorithm based on optimal reaction criterion and a distributed algorithm with limited feedback based on learning automata are presented to obtain the NE of the proposed game. In simulations, the proposed iterative algorithm can achieve a near optimal sum utility of whole network with low complexity compared to the exhaustive search. In addition, the simulation results show that our proposed algorithms outperform existing methods in terms of sum utility and load balance.
Transitions of (The) Flower Drum Song: From Chin Yang Lee to David Henry Hwang
Hui Tian 한국영미어문학회 2024 영미어문학 Vol.- No.152
The Flower Drum Song, written by Chin Yang Lee, and its homonymous musical adaptation by David Henry Hwang, are two seminal American works exploring Chinese American life. However, the musical has undergone significant transformations in various aspects. Therefore, this study aims to examine the transitions of (The) Flower Drum Song in settings, character portrayals, as well as the presentation and preservation of Chinese culture. The findings reveal that David Henry Hwang demonstrates a more proactive and independent motivation in portraying Chinese Americans compared to Chin Yang Lee; However, he falls short in effectively presenting and preserving Chinese culture as skillfully accomplished by Chin Yang Lee. David Henry Hwang's Flower Drum Song presents a more accurate portrayal of characters, while Chin Yang Lee's novel better preserves traditional Chinese culture. Generally, the transitions of settings, character portrayals, and plotlines are progress in Hwang’s musical, while the transition of Chinese cultural portrayal presents some retrogress, compared with that in Lee’s novel.
A Novel Intrusion Detection Approach Based on Chaos Theory in Wireless Sensor Network
Xinling Kong,Yonghong Chen,HuiTian,Tian Wang,Yiqiao Cai 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.11
With the development of technology, wireless sensor networks(WSNs) has been widely used in military, political, medical and other fields, their characteristics of data-centric become increasingly prominent. In this paper, a data-oriented intruding detection method based on chaos theoy is proposed. We use the theory of chaotic system to analyze the internal rules of the sensory data and predict the data by RBF neural network firstly, then make an initial detection of false injected data attack according to whether the difference between the predicted and actual value is more than the threshold, finally confirming the attack by checking whether the number of abnormal within the cycle lies in the corresponding range. Experimental results show that RBF neural network predict sensory data more accurate, our approach can effectively distinguish the abnormal events caused by the attack or environmental factors and has high intrusion detection accuracy.