http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Hui-ge Xing (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Upregulation and biological function of transmembrane protein 119 in osteosarcoma
Zhen-Huan Jiang,Jun Peng,Hui-Lin Yang,Xing-Li Fu,Jin-Zhi Wang,Lei Liu,Jian-Nong Jiang,Yong-Fei Tan,Zhi-Jun Ge 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Osteosarcoma is suggested to be caused by genetic and molecular alterations that disrupt osteoblast differentiation. Recent studies have reported that transmembrane protein 119 (TMEM119) contributes to osteoblast differentiation and bone development. However, the level of TMEM119 expression and its roles in osteosarcoma have not yet been elucidated. In the present study, TMEM119 mRNA and protein expression was found to be up-regulated in osteosarcoma compared with normal bone cyst tissues. The level of TMEM119 protein expression was strongly associated with tumor size, clinical stage, distant metastasis and overall survival time. Moreover, gene set enrichment analysis (GSEA) of the Gene Expression Omnibus (GEO) GSE42352 dataset revealed TMEM119 expression in osteosarcoma tissues to be positively correlated with cell cycle, apoptosis, metastasis and TGF-β signaling. We then knocked down TMEM119 expression in U2OS and MG63 cells using small interfering RNA, which revealed that downregulation of TMEM119 could inhibit the proliferation of osteosarcoma cells by inducing cell cycle arrest in G0/G1 phase and apoptosis. We also found that TMEM119 knockdown significantly inhibited cell migration and invasion, and decreased the expression of TGF-β pathway-related factors (BMP2, BMP7 and TGF-β). TGF-β application rescued the inhibitory effects of TMEM119 knockdown on osteosarcoma cell migration and invasion. Further in vitro experiments with a TGF-β inhibitor (SB431542) or BMP inhibitor (dorsomorphin) suggested that TMEM119 significantly promotes cell migration and invasion, partly through TGF-β/BMP signaling. In conclusion, our data support the notion that TMEM119 contributes to the proliferation, migration and invasion of osteosarcoma cells, and functions as an oncogene in osteosarcoma.
-
A reliability analysis method for rock slope controlled by weak structural surface
Jia-wen Zhou,Ming-yuan Jiao,Hui-ge Xing,Xing-guo Yang,Yu-chuan Yang 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.3
Catastrophic landslides maybe occur in rock slope due to the effect of strong earthquakes or heavy rainfall. The stability of rock slope is usually controlled by different scales of weak structural surfaces, which are uncertain and randomly exist in the rock slope. According to the geological characteristics of rock slope, two typical failure modes – plane and wedge are possible. A second-order second-moment (SOSM) method is presented to calculate the reliability index and the failure probability of rock slope, which is an improvement over the first-order second-moment (FOSM) method, and performance functions are built up with the classic limit equilibrium method. The presented method is applied to analyze the failure probability of two rock slopes at the Jinping I Hydropower Station and is compared with the Monte Carlo method and the FOSM method. The computed results show that for plane failure, the reliability index and the failure probability determined by the presented method are 0.563 and 28.7%, respectively, and the reliability index and the failure probability determined by Monte Carlo method are 0.677 and 24.9%, respectively. However, for the FOSM method, the reliability index and failure probability are –0.025 and 51.0%, respectively. For both plane failure and wedge failure, the difference between the presented method and the Monte Carlo method is very small, but the failure probability of plane failure determined by FOSM method is larger than that of the other two methods. The presented method can provide a useful tool to evaluate the failure probability of rock slope.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
