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        Covalently Crosslinked Chitosan-Poly(ethylene glycol) Hybrid Hydrogels to Deliver Insulin for Adipose-Derived Stem Cells Encapsulation

        Huaping Tan,Hekun Luan,Yihang Hu,Xiaohong Hu 한국고분자학회 2013 Macromolecular Research Vol.21 No.4

        Biodegradable hydrogels carrying adipose-derived stem cells (ASCs) have been highlighted with promising potential regarding adipose tissue engineering. In this study, covalently crosslinked natural/synthetic hybrid hydrogels were prepared from methacrylated water soluble chitosan (N-succinyl-chitosan, SCS) and poly(ethylene glycol) (PEG) by photoinitiaing polymerization under the existence of Irgacure 2959 and the irradiation of UV light. The effect of the incorporated PEG on the in vitro morphologies, equilibrium swelling, weight loss and compressive modulus of SCS/PEG hybrid hydrogels in phosphate buffered saline (PBS) at 37 oC were studied. In order to evaluate the ability of hydrogels to effectively deliver the adipogenic factor, insulin was entrapped within hydrogels by copolymerizing methacrylated SCS/PEG. The insulin would be released from the hydrogels into the local microenvironment via the controlled weight ratio of SCS/PEG. Results demonstrated that the hybrid hydrogel with 10 wt%PEG showed a higher efficiency of insulin delivery compared to the control hydrogels. ASCs were seeded into the insulin-loaded SCS/PEG hydrogels in vitro to assess the biological performance and applicability of hydrogels as cell carriers. These characteristics provide potential opportunities for the hybrid SCS/PEG hydrogels as injectable scaffolds in soft tissue engineering applications.

      • What Drives Residents Low Carbon Transportation Commuting? Evidence from China

        Li, Liang,Tan, Meixuen,Sun, Huaping,Sanitnuan, Nuttida Kyung Hee University Management Research Institute 2021 Asia pacific journal of business review Vol.6 No.1

        Promoting low carbon transportation adoption is important for energy saving. Some prior studies have discussed on environmental values affect low carbon transportation commuting is inconclusive. This study has constructed the environmental values, utility value, and social influence-based low-carbon transportation adoption model through the theory of the technology acceptance model and VBN model and the IS success model. Through the SEM model and stepwise regression analysis, we have found that environmental values positively affect utility value, and utility value also positively affects the behavior adoption of low carbon transportation. The utility value as mediating effect in the relationship between environmental values and low carbon transportation commuting behavior. Besides, we also have found that social influence positively impacts the behavior adoption of low carbon transportation. It better enhances the level of household residents' environmental values and utility values, and social influence for promoting the adoption of low carbon transportation. This present research provides theoretical guidance and suggestions for promoting the development of low-carbon transportation innovation.

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