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Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responses
Tsung-Hsien Tsai,Lu-Te Chuang,Tsung-Jung Lien,Yau-Rong Liing,Wei-Yu Chen,Po-Jung Tsai 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.4
Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes–induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes–stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes–induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes–induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes–induced inflammation.
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Chih-Hsien Lin,Shao-Kung Hung,Mei-Yung Chen,Shan-Tsung Li,Li-Chen Fu 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
This paper proposes a novel planar electromagnetic-actuated positioning stage. The stage is suspended by the monolithic parallel flexure mechanism, which motion comes from the deformation of the flexure. A linear electromagnetic actuator which consists of a near-uniform magnetic field and four coils is designed and implementation to provide the propelling force for 3-DOF motions. In order to suppress the vibration of the flexure suspension mechanism, an eddy current damper is designed and integrated with the electromagnetic actuator. The non-contact damper is more advanced than the contact damper used in our previous researches. The design traveling range is 3mm × 3mm in planar motion. The experimental results show the vibration of the flexure mechanism could be suppressed by the designed eddy current damper. The results also show the regulation and tracking performance by a well-designed robust adaptive sliding mode controller, which can overcome the disturbance and modeling uncertainty and guarantee a satisfactory performance.
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Wen-Pin Lee,Mei-Ling Li,Yun-Ta Liu,Chung-Ming Lee,Hsien-Tsung Yao 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1
Qing-Yu-Mu (QYM) is an herbal formula used to prevent and treat liver disease in Taiwan. In this study, the hepatoprotective effects of QYM were evaluated in two experimental models. First, rats were fed a high-frying oil (FO) diet containing 1.25% QYM for 5 weeks to investigate effects of QYM on hepatic oxidative stress and antioxidant enzyme activities. Then, protective effects of QYM on carbon tetrachloride (CCl4)-induced chronic liver injury were evaluated. Results show that QYM treatment reduced FO diet-induced hepatic lipid peroxidation and reactive oxygen species levels and increased glutathione (GSH) S-transferase activity. A higher reduced GSH/oxidized GSH (GSSG) ratio was observed after QYM treatment. Furthermore, QYM ameliorated CCl4-induced liver injury by reducing the activity of plasma alanine aminotransferase and histological lesions in the liver. QYM also increased the level of hepatic GSH and activities of GSH peroxidase and superoxide dismutase. Finally, chlorogenic acid, chrysophanol, and apigenin were found to be present in relative abundance in QYM. Results show that QYM may exhibit a hepatoprotective effect by reducing oxidative stress and increasing antioxidant activity in the liver.
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Effects of Neodymium and Calcium on the Thermal Stability of AZ71 Magnesium Alloys
Cheng‑Feng Yue,Shi‑Jei Huang,Jhewn‑Kuang Chen,Hsien‑Tsung Li,Kam‑Shau Chan 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.2
The effects of an addition of 0–2 wt% Nd on thermal stability of 0–3 wt% Ca-containing modified AZ71 magnesium alloyswas investigated. The ignition temperature was found to increase from that of AZ71, 574, to 825 °C with the addition of0.5 wt% Ca and 1 wt% Nd. The ignition temperature was further increased to 1114 °C when 3 wt% Ca was added. The CaandNd-added AZ71 was isothermally maintained at a temperature of 500 °C in air for 12 h. The MgO–CaO–Nd2O3 formedon the surface to improve the thermal stability of the AZ71–xCa–yNd alloys. While both the tensile strength and ductilitydecreased with the Ca concentration in the alloy, an addition of 1 wt% Nd was found able to alleviate the degradation effectsof Ca on the tensile strength and ductility at 170 °C. Both solid solution formation and precipitation strengthening contributedto the increase in toughness. AZ71 containing 0.5–2 wt% Ca and 1 wt% Nd provides the optimum combination of ignitionresistance and mechanical properties.
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