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Analysis of dynamic RBC aggregation in microfluidic device using laser backscattering
Hou Jianxun(호우지엔쉰),Yunhee Ku(구윤희),Sehyun Shin(신세현),Jangsoo Suh(서장수) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
The aggregation characteristics of red blood cells (RBCs) play an important role in microvascular flow system and increased RBC aggregation has been observed in various pathological diseases, such as thrombosis and myocardial infarction. This paper presents a novel microfluidic device for evaluating the aggregability of RBCs on the flow of blood by directly measuring aggregating force (critical shear stress) to overcome shearing force due to flow in a microchannel. The device functionality is based on a microfluidic slit rheometry with decreasing pressure-driven flow mechanism with laser light backscattering technique. The present RBC aggregation index shows a higher sensitivity to small changes of aggregation modulated by amount of fibrinogen in blood plasma. The direct measurement of RBC aggregating force represents a new concept for the field of blood rheology and should prove beneficial for basic science and clinical applications.
A Novel Stress-Scanning Microfluidic Assay of RBC Aggregation Characteristics
Yijie Yang(양 이지에),Jianxun Hou(호우 지엔쉰),Jaeyong Ko(고재용),Jeonghun Nam(남정훈),ChangBeom Kim(김창범),Sehyun Shin(신세현) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
Red blood cell (RBC) aggregation is a hemorheological characteristic which plays an important role in microcirculation. This paper presents a new approach using optical method and shear stress-scanning mechanism to measuring RBC aggregation in varied shear flow. The backscattered light intensity and shear stress were measured in a microchannel with respect to time. Then, the critical time and critical shear stress were introduced, as newly-proposed indexes of aggregation, after analysis of the time recording of the backscattered light intensity and shear stress. It is experimentally proven that the new indexes quantitatively represent the aggregation characteristics of RBC-plasma suspensions with varying fibrinogen concentrations. The present approach to measuring RBC aggregation offers a new concept in the study of hemorheology and has potential to be applied to basic science research and point-of-care use.