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RISS 인기검색어
- 검색키워드
- 저자 : Hossein Moslemi (검색결과 3 건)
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A review on electrochemical behavior of pyrite in the froth flotation process
Hossein Moslemi,Mahdi Gharabaghi 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.47 No.-
Metal sulfides are usually semiconductor and cause electrochemical reactions. This phenomenon playsan important role in sulfideflotation. Pyrite as the most abundant sulfide mineral is often associated withvaluable sulfide minerals, coal and gold. It is very important to study its electrochemical behavior in theflotation process. This review focuses on researches carried out over the past several decades that havestudied electrochemical processes associated with pyrite occurring duringflotation. The mechanism ofprocesses such as oxidation, activation, depression, and interactions of activated and non-activatedsurfaces with collectors as well as factors affecting them are described. Moreover, the effect ofelectrochemical conditions during grinding on theflotation process is also discussed. It has been foundthat moderately oxidizing conditions are favorable for collector-lessflotation of pyrite while stronglyreducing or oxidizing potentials lead to its depression. Increasing the electrochemical potential not onlyhas a deleterious effect on the activation of pyrite by copper, but also facilitates its depression bydepressants. In the case of the adsorption of xanthate whether on activated or non-activated surfaces, agreat increase or decrease in the potential has adverse effects and it is necessary to optimize theelectrochemical conditions. Various factors such as pH, solid percentage, particle size distribution,flotation time, type and concentration of reagents and oxygen content as well as grinding conditions canaffect the intensity of these electrochemical interactions. It is proposed that further researches usingadvanced chemical analysis techniques are needed to understand the electrochemical processes involvedinflotation systems.
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Bayesian Survival Analysis of High-Dimensional Microarray Data for Mantle Cell Lymphoma Patients
Moslemi, Azam,Mahjub, Hossein,Saidijam, Massoud,Poorolajal, Jalal,Soltanian, Ali Reza Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1
Background: Survival time of lymphoma patients can be estimated with the help of microarray technology. In this study, with the use of iterative Bayesian Model Averaging (BMA) method, survival time of Mantle Cell Lymphoma patients (MCL) was estimated and in reference to the findings, patients were divided into two high-risk and low-risk groups. Materials and Methods: In this study, gene expression data of MCL patients were used in order to select a subset of genes for survival analysis with microarray data, using the iterative BMA method. To evaluate the performance of the method, patients were divided into high-risk and low-risk based on their scores. Performance prediction was investigated using the log-rank test. The bioconductor package "iterativeBMAsurv" was applied with R statistical software for classification and survival analysis. Results: In this study, 25 genes associated with survival for MCL patients were identified across 132 selected models. The maximum likelihood estimate coefficients of the selected genes and the posterior probabilities of the selected models were obtained from training data. Using this method, patients could be separated into high-risk and low-risk groups with high significance (p<0.001). Conclusions: The iterative BMA algorithm has high precision and ability for survival analysis. This method is capable of identifying a few predictive variables associated with survival, among many variables in a set of microarray data. Therefore, it can be used as a low-cost diagnostic tool in clinical research.
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Preparation of Immunotoxin Herceptin-Botulinum and Killing Effects on Two Breast Cancer Cell Lines
Hajighasemlou, Saieh,Alebouyeh, Mahmoud,Rastegar, Hossein,Manzari, Mojgan Taghizadeh,Mirmoghtadaei, Milad,Moayedi, Behjat,Ahmadzadeh, Maryam,Parvizpour, Farzad,Johari, Behrooz,Naeini, Maria Moslemi,Fa Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: Worldwide, breast cancer is the most common cancer diagnosed among women and a leading cause of cancer deaths. The age of onset in Iran has become reduced by a decade for unknown reasons. Herceptin, a humanized monoclonal antibody, is a target therapy for breast cancer cells with over expression of HER2-neu receptors, but it is an expensive drug with only 20% beneficial rate of survival. This study introduces a novel approach to enhance the efficacy of this drug through immunoconjugation of the antibody to botulinum toxin. Decreasing the cost and adverse effects of the antibody were secondary goals of this study. Materials and Methods: Botulinum toxin was conjugated with Herceptin using heterobifunctional cross linkers, succinimidyl acetylthiopropionate (SATP) and sulfo-succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) according to the supplier's guidelines and tested on two breast cancer cell lines: SK-BR-3 and BT-474. Toxin and Herceptin were also used separately as controls. The cytotoxicity assay was also performed using the new bioconjugate on cultured cells with Alamar blue and a fluorescence plate reader. Results: Herceptin-Toxin bioconjugation significantly improved Herceptin efficacy on both breast cancer cell lines when compared to the control group. Conclusions: Toxin-Herceptin bioconjugation can be a potential candidate with increased efficiency for treating breast cancer patients with over expression of the HER2 receptor.
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