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Hur†, Jung A,Bae, Suk Young,Kim, Kyung Hwan,Lee, Tae Wan,Cho, Min Ju,Choi, Dong Hoon American Chemical Society 2011 ORGANIC LETTERS Vol.13 No.8
<P>2,6-Bis((4-hexylphenyl)ethynyl)-9,10-bis(phenylethynyl)anthracene, <B>4</B>, and 9,10-bis((4-hexylphenyl)ethynyl)-2,6-bis (phenyl ethynyl)anthracene, <B>5</B>, have been synthesized to study their electronic and photophysical properties. It should be noted that the difference between these compounds is the substitution position of 1-ethynyl-4-hexylbenzene groups into an anthracene ring. In particular, substitution in the 9,10-positions of the anthracene ring enhanced J-aggregated intermolecular interactions. Since <B>5</B> has a lower bandgap energy and more compact film morphology, it exhibited higher hole mobility (∼0.27 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>) in thin-film transistor devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2011/orlef7.2011.13.issue-8/ol200299s/production/images/medium/ol-2011-00299s_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol200299s'>ACS Electronic Supporting Info</A></P>
LEE, DAKEUN,YU, EUN JI,HAM, IN-HYE,HUR2, HOON Potamitis Press 2017 Anticancer research Vol.37 No.1
<P>Background: The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood. Materials and Methods: Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups. Results: High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival. Conclusion: Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs.</P>
Relevance of Light Spectra to Growth of the Rearing Tiger Puffer Takifugu rubripes
Byeong-Hoon Kim,Sung-Pyo Hur,Sang-Woo Hur,Chi-Hoon Lee,Young-Don Lee 한국발생생물학회 2016 발생과 생식 Vol.20 No.1
In fish, light (photoperiod, intensity and spectra) is main regulator in many physiological actions including growth. We investigate the effect of light spectra on the somatic growth and growth-related gene expression in the rearing tiger puffer. Fish was reared under different light spectra (blue, green and red) for 8 weeks. Fish body weight and total length were promoted when reared under green light condition than red light condition. Expression of somatostatins (ss1 and ss2) in brain were showed higher expression under red light condition than green light condition. The ss3 mRNA was observed only higher expression in blue light condition. Expression of growth hormone (gh) in pituitary was detected no different levels between experimental groups. However, the fish of green light condition group was showed more high weight gain and feed efficiency than other light condition groups. Our present results suggest that somatic growth of tiger puffer is induced under green light condition because of inhibiting ss mRNA expression in brain by effect of green wavelength.
[PF-0006] Morphological characterization of mustard (Brassica juncea) germplasm from Korea
Seong-Hoon Kim(Seong-Hoon Kim),Bum-Soo Hahn(Bum-Soo Hahn),Ho Chul Ko(Ho Chul Ko),Onsook Hur(Onsook Hur),Aejin Hwang(Aejin Hwang),Bichsaem Kim(Bichsaem Kim),Yoon-Jung Lee(Yoon-Jung Lee),Parthiban Subra 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Hur, Dong Hoon,Na, Jeong‐,Geol,Lee, Eun Yeol WILEY & SONS 2017 Journal of Chemical Technology & Biotechnology Vol. No.
<P>CONCLUSION: It was demonstrated that isolation and application of a new methanotroph strain is a practical way of improving bioconversion efficiency in the conversion of methane to methanol. Moreover, one promising feature of Methylomonas sp. DH-1 for methanol production was its extremely high tolerance to methanol up to 7%(v/v), which is advantageous for high-titer methanol production. (C) 2016 Society of Chemical Industry</P>
Hur, Hoon,Lee, Sang Rim,Xuan, Yi,Kim, Young Bae,Lim, Young Ae,Cho, Yong Kwan,Han, Sang-Uk The Korean Surgical Society 2012 Annals of Surgical Treatment and Research Vol.83 No.4
<P><B>Purpose</B></P><P>The goal of this study was to assess the correlation between the <I>Helicobacter pylori</I> status of patients who underwent curative resection for gastric adenocarcinoma and their prognosis in Eastern societies where <I>H. pylori</I> infection is prevalent.</P><P><B>Methods</B></P><P>Between 2006 and 2007, 192 patients who had a curative resection for the treatment of gastric adenocarcinoma were enrolled in the study. Of these patients, 18 were excluded due to an inexact evaluation of the <I>H. pylori</I> status, thereby leaving 174 patients in the final analysis. Serologic testing for <I>H. pylori</I> was assessed using an enzyme-linked immunosorbent assay kit for immunoglobulin G, and the histological presence of <I>H. pylori</I> was identified using the Giemsa stain.</P><P><B>Results</B></P><P>Of the 174 patients, 111 patients (63.8%) were confirmed for <I>H. pylori</I> infection. <I>H. pylori</I> status did not correlate with the overall or disease-free survival. For patients with stage III or IV gastric cancer, a positive <I>H. pylori</I> status was a significant predictive factor for recurrence over that of a negative <I>H. pylori</I> status (P = 0.019). Negative <I>H. pylori</I> status was a predictive factor for recurrence in multivariable analysis (relative risk, 2.724; 95 confidence interval, 1.192 to 6.228).</P><P><B>Conclusion</B></P><P><I>Helicobacter pylori</I> status did not correlate with the clinicopathologic factors of gastric adenocarcinoma. However, a negative <I>Helicobacter pylori</I> status may be a predictive factor for recurrence in patients diagnosed with advanced gastric adenocarcinoma.</P>
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target
HUR, HOON,XUAN, YI,KIM, YOUNG BAE,LEE, GWANG,SHIM, WOOYOUNG,YUN, JISOO,HAM, IN-HYE,HAN, SANG-UK D.A. Spandidos 2013 International journal of oncology Vol.42 No.1
<P>In contrast to mitochondria in healthy cells, which utilize oxidative phosphorylation, malignant cells undergo elevated glycolysis for energy production using glucose. The objectives of this study were to evaluate whether the expression of various molecules, including pyruvate dehydrogenase kinase-1 (PDK-1), is involved in the altered glucose metabolism associated with gastric cancer prognosis and to assess the role of a therapeutic agent in targeting glucose metabolism in gastric cancer. Immunohistochemistry was performed on gastric cancer tissues obtained from 152 patients who underwent curative resection to assess the expression of hypoxia-inducible factor-1α (HIF-1α), glucose transporter-1 (GLUT-1), hexokinase-2 (HK-2) and PDK-1. In an <I>in vitro</I> analysis, the lactate production and glucose uptake levels, cellular viability and 5-fluorouracil (5-FU) responses were evaluated before and after treatment with dichloroacetate (DCA), a PDK-1 inhibitor, in the MKN45 and AGS gastric cancer cell lines and in the non-cancerous HEK293 cell line. GLUT-1 and PDK-1 expression was significantly associated with tumor progression, although only PDK-1 expression was an independent prognostic factor for patients who received 5-FU adjuvant treatment. There was no significant difference in cell viability between the HEK293 and gastric cancer cell lines following DCA treatment. However, DCA treatment reduced lactate production and increased responsiveness to 5-FU in MKN45 cells, which expressed high levels of PDK-1 in comparison to the other cell lines. Thus, PDK-1 may serve as a biomarker of poor prognosis in patients with gastric cancer. In addition, PDK-1 inhibitors such as DCA may be considered an additional treatment option for patients with PDK-1-expressing gastric cancers.</P>