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Efficient Certificateless Signcryption from Bilinear Pairings
Hongzhen Du 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.4
Certificateless public key cryptography is an attractive paradigm which combines advantages of both traditional certificate-based and ID-based public key cryptosystems. In this paper, the author formalizes the definition and the security model for certificateless signcryption (CLSC), and proposes a CLSC scheme that is proved to be secure in the random oracle model. The CLSC scheme satisfies such desirable properties as message confidentiality, signature unforgability, public verifiability and forward secrecy. Moreover, the scheme achieves significant efficiency in that it requires general cryptographic hash functions instead of the MapToPoint function which is inefficient and probabilistic, and the public/private key of a user in the scheme is a single group element, and it is unnecessary to check the validity of the public key, and signcryption algorithm needs no pairing operation while the reverse operation only requires two pairing computations.
Polydiacetone Acrylamide as Precursors to Polymer Side-Chain Conjugates
Hongzhen Tan,Zhipeng Yu,Junjie Xiao,Xi Wang,Chunwang Yi,Shengpei Su 한국고분자학회 2018 폴리머 Vol.42 No.4
Polydiacetone acrylamide (PDAAM), a reactive polymer containing pendant ketone groups was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Kinetic studies indicated a well-controlled behavior of this RAFT polymerization. The characteristics of this RAFT polymerization was also confirmed by a wellcontrolled chain-extending RAFT polymerization using the above-synthesized PDAAM as a macromolecular chain transfer agent. Acid-catalyzed ketalization of PDAAM with trimethylol propane (TMP) was carried out to obtain the polymer containing pendant cyclic ketal groups and hydroxyl groups, PDAAM-TMP. PCL was grafted from PDAAM-TMP by ring-opening polymerization (ROP) in the presence of tin 2-ethylhexanoate as a catalyst to obtain graft copolymer. Basecatalyzed aldol condensation of PDAAM with benzaldehyde was also used to obtain poly[N-(1,1-dimethyl-3-oxo-5-phenyl-pent-4-enyl)-acrylamide] (PDMOPPEAM) having cinnamoyl groups, and the photoreactivity of polymer with cinnamoyl group was studied by UV-visible and IR absorption spectroscopy. Both of these two polymers prepared from PDAAM were characterized by FTIR and 1H NMR spectroscopy. PDAAM can be a multifunctional platform that can undergo further polymerization by ketalization and aldol condensation.
Cryptanalysis of a Certificateless Ring Signcryption Scheme
Hongzhen Du,Qiaoyan Wen 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.7
Certificateless public key cryptography (CL-PKC) is an appealing paradigm with the advantages of both conventional public key cryptosystem and ID-based cryptosystem because it avoids using certificates and eliminates the key escrow problem. Ring signcryption is an attractive primitive which allows one user to send a message anonymously, confidentially and authentically. Recently, Qi et al. proposed a novel certificateless ring signcryption scheme with bilinear pairings, and claimed the scheme is provably-secure in the random oracle model. In this paper, we reveal that Qi et al.’s scheme is not secure against both a Type I adversary and a Type II adversary. By giving specific attacks, we found it is unable to meet the fundamental requirements of confidentiality and unforgeability.
Hongzhen Zhang,Ronghua Xu,Zuowen Yin,Jun Yu,Ning Liang,Geng Qian 한국고분자학회 2022 Macromolecular Research Vol.30 No.1
Wound treatment is an important issue and poses a critical challenge for healthcare systems. It is of great significance to develop materials for wound repair and regeneration. Herein, we presented a kind of novel drug-loaded methacryloyl chondroitin sulfate (CSMA) microspheres for promoting the wound healing process. The CSMA droplets were generated from microfluidic electrospray and polymerized with ultraviolet light. With further freeze-drying and drug uploading, the drugloaded CSMA microspheres were achieved. The prepared microspheres exhibited excellent biocompatibility, and the following animal experiments indicated they could promote wound healing significantly. This study opens the door to drug-loaded CSMA microspheres for wound healing applications.
High NDRG3 expression facilitates HCC metastasis by promoting nuclear translocation of β-catenin
( Jikui Shi ),( Hongzhen Zheng ),( Lingyan Yuan ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.7
NDRG1 has been reported to exert pivotal roles in tumor progression and metastasis via Wnt/β-catenin signaling pathway. However, little is known about the role of NDRG3 in hepatocarcinogenesis despite its classification in the same subfamily of NDRG1. The present study was aimed to characterize the expression pattern and understand the biological roles of NDRG3 in hepatocarcinogenesis, as a means to exploit its therapeutic potential. It was observed that NDRG3 was up-regulated in HCC tissues and higher NDRG3 expression was associated with significantly shorter overall survival. Furthermore, a lower level of NDRG3 exhibited marked positive correlation with metastasis-free survival. In vitro and in vivo experiments revealed that knock-down of NDRG3 inhibits HCC metastasis and angiogenesis. We further demonstrated that activation of WNT/β-catenin signaling and enhanced CSC-like properties were responsible for NDRG3-mediated promoting effect on HCC. In conclusion, the principal findings demonstrated that high NDRG3 expression facilitates HCC metastasis via regulating the turnover of β-catenin, as well as provides a potential therapeutic target for future therapeutic interventions. [BMB Reports 2019; 52(7): 451-456]
Dynamic Awareness Method for Network Threats based on Rough Vulnerability Relation Model
Jieyun Xu,Hongzhen Xu 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.7
In order to solve the redundancy question in complex network which is caused by similar attack method and similar node object in attack model, the node domain and transition domain of Petri Net are divided into equivalence classes, and then the construction method of rough vulnerability relation model is given. By defining similar degree of path, search for all of the characteristic attack path which can attain attack object by use of ant algorithm, and calculate the maximal threat of object node which is brought by characteristic strategy. In order to ensure threat prediction suit for attack scene, dynamic perception method of network threat is proposed, which relies on Intrusion Detection Systems (IDS) warning to amend threat value constantly.
Enrichment and isolation of phenol from its aqueous solution using foam fractionation
Shenghao Guo,Zhao Liang Wu,Wei Liu,Hongzhen Li,Di Huang,Nan Hu 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.36 No.-
In this work, the feasibility of foam fractionation for the enrichment and isolation of phenol from itsaqueous solution was studied by using cetyltrimethyl ammonium bromide (CTAB) as the collector. Atwo-stage foam fractionation technology was developed for simultaneously obtaining a high enrichmentratio and a high recovery percentage. Under the suitable operating conditions, the enrichment ratio andrecovery percentage of phenol reached as high as 84.46 and 93.43%, respectively. Subsequently, foamfractionation was also used to isolate phenol from CTAB in the first stage foamate, in which theinteraction between phenol and CTAB could be weakened by adjusting pH. The concentration of CTABsignificantly decreased from 11.230 g/L in the feeding solution to 0.620 g/L in the residual solution byusing the foam fractionation, while the concentration of phenol slightly decreased from 2.533 g/L to2.450 g/L. The results indicated that it was practicable to successively enrich and isolate phenol from itsaqueous solution by using foam fractionation.
Yang Wang,Victoria Nisenblat,Liyuan Tao,XinYu Zhang,Hongzhen Li,Caihong Ma 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3
Objective: To evaluate the effectiveness of oral contraceptive pill (OCP) as therapy for endometrial hyperplasia (EH) without atypia in reproductive-aged women compared with oral progestin. Methods: A retrospective cohort study was carried out in our reproductive center. Consecutive patients diagnosed with infertility and non-atypical EH identified through electronic database who met inclusion criteria (n=309). Patients were assigned to two treatment groups: OCP (n=216) and oral progestin (n=93); clinical and reproductive outcomes were recorded. Results: Reversal of EH to normal endometrium, clinical pregnancy, live birth and miscarriage rate. Women in OCP group were younger, had higher prevalence of Polycystic Ovary Syndrome and other uterine pathology and longer duration of infertility than women in progestin group. Reversal of EH was observed in 93.52% women on OCP and in 86.02% women on progestin (p=0.032; adjusted odds ratio [aOR]= 2.35; 95% confidence interval [CI]=1.06-5.21) after the initial course of treatment for 2 to 6 months. Cyclic OCP (n=184) resulted in better response to treatment compared to continuous OCP (n=32) (95.11% vs. 84.38%; p=0.039; aOR =3.60; 95% CI =1.12-11.55). Clinical pregnancy rate in OCP group was marginally higher than progestin group (87/208, 41.83% vs. 27/90, 30.00%; p=0.054). Miscarriage (25.29% vs. 29.63%; p=0.654) and live birth rate (31.25% vs. 21.11%; p=0.074) were comparable between the groups. Conclusion: For the first time we demonstrate that OCP is an effective therapy for nonatypical EH and is associated with higher remission rate compared with oral progestin. Reproductive outcomes are reassuring and comparable between the two groups.