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- 저자 : Hongmei Dong (검색결과 3 건)
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Zhu, Zhong-Zheng,Wang, Dong,Cong, Wen-Ming,Jiang, Hongmei,Yu, Yue,Wen, Bing-Ji,Dong, Hui,Zhang, Xiao,Liu, Shu-Fang,Wang, Ai-Zhong,Zhu, Guanshan,Hou, Lifang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Background: Males have a higher prevalence of hepatocellular carcinoma (HCC) than females in general, but the reasons for the sex disparity are still obscure. DNA copy number alteration (CNA) is a major feature of solid tumors including HCC, but whether CNA plays a role in sex-related differences in HCC development has never been evaluated. Methods: High-resolution array comparative genomic hybridization (CGH) was used to examine 17 female and 46 male HCC patients with chronic hepatitis B virus (HBV) infection in Shanghai, China. Two-tailed Fisher's exact or ${\chi}^2$ tests was used to compare CNAs between females and males. Results: The overall frequencies and patterns of CNAs in female and male cases were similar. However, female HCC tumors presented more copy number gains compared to those in males on 1q21.3-q22 (76.5% vs. 37.0%, P = 0.009), 11q11 (35.3% vs. 0.0%, P = 0.0002) and 19q13.31-q13.32 (23.5% vs. 0.0%, P = 0.004), and loss on 16p11.2 (35.3% vs. 6.5%, P = 0.009). Relative to females, male cases had greater copy number loss on 11q11 (63.0% vs. 17.6%, P = 0.002). Further analyses showed that 11q11 gain correlated with 19q13.31-q13.32 gain (P = 0.042), 11q11 loss (P = 0.011) and 16p11.2 loss (P = 0.033), while 1q21.3-q22 gain correlated with 19q13.31-q13.32 gain (P = 0.046). Conclusions: These findings suggest that CNAs may play a role in sex-related differences in HBVassociated HCC development.
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Xin Qiao,Silian Zhu,Shujiao Zhang,Hongmei Dong 한국바이오칩학회 2017 BioChip Journal Vol.11 No.1
To identify disrupted pathways associated with neonatal sepsis, we performed a research based on the combination of protein-protein interactions (PPIs) and pathway data. Firstly, a total of 23,292 genes, 787,896 PPIs and 1,675 human pathways were obtained, respectively. Then, under the threshold value of false discovery rate (FDR)<0.05 and a delta cut-off value >4.36, a total of 986 differentially expressed genes (DEGs) were identified. In the following, by degree centrality for the objective PPI network, 20 hub genes were obtained. Finally, pathway enrichment analysis and randomization tests indicated that pathways of gene expression, immune system and innate immune system were with remarkable significance in neonatal sepsis. Therefore, in the present study, we presented a novel pathway method, and we successfully identified several pathways in neonatal sepsis, which might be underlying indicators in the detection and treatment of neonatal sepsis.
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Design formulas for vibration control of sagged cables using passive MR dampers
Yuanfeng Duan,Yi-Qing Ni,Hongmei Zhang,Billie F. Jr. Spencer,Jan-Ming Ko,Shenghao Dong 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.6
In this paper, a method for analyzing the damping performance of stay cables incorporating magnetorheological (MR) dampers in the passive control mode is developed taking into account the cable sag and inclination, the damper coefficient, stiffness and mass, and the stiffness of damper support. Both numerical and asymptotic solutions are obtained from complex modal analysis. With the asymptotic solution, analytical formulas that evaluate the equivalent damping ratio of the sagged cable-damper system in consideration of all the above parameters are derived. The main thrust of the present study is to develop an general design formula and a universal curve for the optimal design of MR dampers for adjustable passive control of sagged cables. Two sag-affecting coefficients are derived to reflect the effects of cable sag on the maximum attainable damping ratio and the optimal damper coefficient. For the cable configurations commonly used in cable-stayed bridges, the sag-affecting coefficients are directly expressed in terms of the sag-extensibility parameter to facilitate the control design. A case study on adjustable passive vibration control of the longest cable (536 m) on Stonecutters Bridge is carried out to demonstrate the influence of the sag for the damper design, and to figure out the necessity of adjustability of damper coefficients for achieving maximum damping ratio for different vibration modes.
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