Outcomes of Free-Tension Transobturator Tape (TOT) Surgery under Local Anesthesia versus General Anesthesia for Female Stress Incontinent Treatment

응웬하이박 외 중앙대학교 의과대학 의과학연구소 2011 中央醫大誌 Vol.36 No.3/4

We evaluate our experience with Transobturator Tape (TOT) surgery under local and general anesthesia for treating female stress incontinence. Totally 31 women with genuine urinary incontinent were selected in this study. They were scheduled for TOT surgery under local anesthesia or general anesthesia. The study protocol involved recording of preoperative and perioperative details and postoperative evaluation. Fifteen patients were included in local group and sixteen remainders in the general group. 100% of stress urinary incontinent symptom was cured. The cure rate of urge symptom was 80% vs. 50% for local group vs. general group, respectively, at both short-term and long-term follow-up. There was no significant difference in mean operating room and surgical time. But a statistically significant difference in mean of recovery room time, hospital stays and hospital cost was recorded (p <0.005). We concluded that TOT insertion is a best indication for correcting urinary stress incontinence in women. It can be performed effectively under both local and general anesthesia. Local anesthesia with sedation has advantage only in regarding to recovery time and total hospital cost, but much disadvantage in term of early and late postoperative complications.

Relaxing Effect of Acetylcholine on Phenylephrine-Induced Contraction of Isolated Rabbit Prostate Strips Is Mediated by Neuronal Nitric Oxide Synthase

Hoai Bac Nguyen,이신영,박수현,이무열,장인호,명순철 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.5

Purpose: The location of acetylcholinesterase-containing nerve fibers suggests a role for acetylcholine in both contractility and secretion in the prostate gland. The colocalization of nitrergic nerves with cholinergic nerves, and the cotransmission of nitric oxide with acetylcholine in cholinergic nerves, has been demonstrated in the prostate glands of various species. Thus, we investigated the effects of acetylcholine on phenylephrine-induced contraction and the correlation between cholinergic transmission and nitric oxide synthase by using isolated prostate strips of rabbits. Materials and Methods: Isolated prostate strips were contracted with phenylephrine and then treated with cumulative concentrations of acetylcholine. Changes in acetylcholine-induced relaxation after preincubation with NG-nitroarginine methyl ester,7-nitroindazole, and aminoguanidine were measured. The effects of selective muscarinic receptor antagonists were also evaluated. Results: In the longitudinal phenylephrine-contracted strip, the cumulative application of acetylcholine (10-9 to 10-4 M) elicited a concentration-dependent relaxation effect. Acetylcholine-induced relaxation was inhibited not only by nitric oxide synthase inhibitors (10 μM L-NAME or 10 μM 7-nitroindazole) but also by 10 μM atropine and some selective muscarinic receptor antagonists (10-6 M 11-([2-[(diethylamino)methyl]-1-piperdinyl]acetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one and 10-6M 4-diphenylacetoxy-N-methyl-piperidine). In contrast, relaxation was significantly increased by pretreatment of the strips with 10 mM L-arginine. Conclusions: Acetylcholine relaxed phenylephrine-induced contractions of isolated rabbit prostate strips. This relaxation may be mediated via both cholinergic and constitutive nitric oxide synthase with both the M2 and M3 receptors possibly playing key roles.

Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum

Hoai Bac Nguyen,이신영,박수현,한준현,이무열,명순철 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.3

It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood. Nicotine has been reported to cause relaxation of the corpus cavernosum; it has also been reported to cause both contraction and relaxation. Therefore, high concentrations of nicotine were studied in strips from the rabbit corpus cavernosum to better understand its effects. The proximal penile corpus cavernosal strips from male rabbits weighing approximately 4 kg were used in organ bath studies. Nicotine in high concentrations (10-5∼10-4 M) produced dose-dependent contractions of the corpus cavernosal strips. The incubation with 10-5 M hexamethonium (nicotinic receptor antagonist) significantly inhibited the magnitude of the nicotine associated contractions. The nicotine-induced contractions were not only significantly inhibited by pretreatment with 10-5 M indomethacin (nonspecific cyclooxygenase inhibitor) and with 10-6 M NS-398 (selective cyclooxygenase inhibitor), but also with 10-6 M Y-27632 (Rho kinase inhibitor). Ozagrel (thromboxane A2 synthase inhibitor) and SQ-29548 (highly selective TP receptor antagonist) pretreatments significantly reduced the nicotine-induced contractile amplitude of the strips. High concentrations of nicotine caused contraction of isolated rabbit corpus cavernosal strips. This contraction appeared to be mediated by activation of nicotinic receptors. Rho-kinase and cyclooxygenase pathways, especially cyclooxygenase-2 and thromboxane A2, might play a pivotal role in the mechanism associated with nicotine-induced contraction of the rabbit corpus cavernosum.

Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum

Nguyen, Hoai Bac,Lee, Shin Young,Park, Soo Hyun,Han, Jun Hyun,Lee, Moo Yeol,Myung, Soon Chul The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.3

It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood. Nicotine has been reported to cause relaxation of the corpus cavernosum; it has also been reported to cause both contraction and relaxation. Therefore, high concentrations of nicotine were studied in strips from the rabbit corpus cavernosum to better understand its effects. The proximal penile corpus cavernosal strips from male rabbits weighing approximately 4 kg were used in organ bath studies. Nicotine in high concentrations ($10^{-5}{\sim}10^{-4}M$) produced dose-dependent contractions of the corpus cavernosal strips. The incubation with $10^{-5}M$ hexamethonium (nicotinic receptor antagonist) significantly inhibited the magnitude of the nicotine associated contractions. The nicotine-induced contractions were not only significantly inhibited by pretreatment with $10^{-5}M$ indomethacin (nonspecific cyclooxygenase inhibitor) and with $10^{-6}M$ NS-398 (selective cyclooxygenase inhibitor), but also with $10^{-6}M$ Y-27632 (Rho kinase inhibitor). Ozagrel (thromboxane $A_2$ synthase inhibitor) and SQ-29548 (highly selective TP receptor antagonist) pretreatments significantly reduced the nicotine-induced contractile amplitude of the strips. High concentrations of nicotine caused contraction of isolated rabbit corpus cavernosal strips. This contraction appeared to be mediated by activation of nicotinic receptors. Rho-kinase and cyclooxygenase pathways, especially cyclooxygenase-2 and thromboxane $A_2$, might play a pivotal role in the mechanism associated with nicotine-induced contraction of the rabbit corpus cavernosum.

Real Time Control of an Induction Motor Using IMC Approach

Duong Hoai Nghia,Nguyen Van Nho,Nguyen Xuan Bac,Hong-Hee Lee 전력전자학회 2009 JOURNAL OF POWER ELECTRONICS Vol.9 No.3

The paper presents a method for controlling induction motors using a nonlinear internal model control (IMC) approach. The process model and the inverse model are developed in the rotor flux coordinate. The main advantage of the proposed method is that it easily specifies the performance (steady state error, transient response, etc.) and the robustness of the controller by means of the IMC filters. Simulation results illustrate the effectiveness of the proposed method. Results on a real time system show that the control system has good performance and robustness against changes in motor parameters (rotor and stator resistances, rotor and stator inductances, rotor inertia).

Real Time Control of an Induction Motor Using IMC Approach

Nghia, Duong Hoai,Nho, Nguyen Van,Bac, Nguyen Xuan,Lee, Hong-Hee The Korean Institute of Power Electronics 2009 JOURNAL OF POWER ELECTRONICS Vol.9 No.3

The paper presents a method for controlling induction motors using a nonlinear internal model control (IMC) approach. The process model and the inverse model are developed in the rotor flux coordinate. The main advantage of the proposed method is that it easily specifies the performance (steady state error, transient response, etc.) and the robustness of the controller by means of the IMC filters. Simulation results illustrate the effectiveness of the proposed method. Results on a real time system show that the control system has good performance and robustness against changes in motor parameters (rotor and stator resistances, rotor and stator inductances, rotor inertia).

Bilateral Recurrent Thigh Abscesses for Five Years after a Transobturator Tape Implantation for Stress Urinary Incontinence

이신영,김준영,박세준,권용욱,Hoai Bac Nguyen,장인호,김태형,김영선 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.9

The synthetic, tension-free midurethral sling procedure using transobturator tape (TOT) was introduced in 2001 and has become the most widely used procedure for the treatment of female urinary incontinence worldwide. However, infectious complications associated with erosions have occasionally been reported because of a foreign body reaction to the polypropylene mesh. We observed a case of a bilateral recurrent thigh abscess manifesting 5 years after a TOT sling procedure. The patient had recurrent thigh abscesses with repeated incisions and drainages in the past 1 year. Five months earlier, she had undergone a procedure to remove the eroded suburethral mesh, but incompletely. The right thigh abscess recurred, and ultimately the residual mesh was completely excised with abscess drainage. Complete mesh removal is very important to prevent abscess recurrence, and it is necessary for any urologist treating women who have undergone the TOT procedure to be aware of the possibility of abscesses occurring for a long time after the operation.