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A Method of Goodness-of-Fit Test for Stochastic Processes
Hirotada Honda 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
A method of goodness-af-fit test for stochastic processes from time sequence values of a sample path is discussed in this paper. Based on the Fokker-Plank equation of the stochastic process and transform of the coordinate system, observes values at each time are mapped to those generated form the same probalbility density function. Applying AD statistics and bootstrap method, goodness-of-fit test of them is enabled.
From the Sequence to Cell Modeling: Comprehensive Functional Genomics in Escherichia coli
Mori, Hirotada Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.1
As a result of the enormous amount of information that has been collected with E. coli over the past half century (e.g. genome sequence, mutant phenotypes, metabolic and regulatory networks, etc.), we now have detailed knowledge about gene regulation, protein activity, several hundred enzyme reactions, metabolic pathways, macromolecular machines, and regulatory interactions for this model organism. However, understanding how all these processes interact to form a living cell will require further characterization, quantification, data integration, and mathematical modeling, systems biology. No organism can rival E. coli with respect to the amount of available basic information and experimental tractability for the technologies needed for this undertaking. A focused, systematic effort to understand the E. coli cell will accelerate the development of new post-genomic technologies, including both experimental and computational tools. It will also lead to new technologies that will be applicable to other organisms, from microbes to plants, animals, and humans. E. coli is not only the best studied free-living model organism, but is also an extensively used microbe for industrial applications, especially for the production of small molecules of interest. It is an excellent representative of Gram-negative commensal bacteria. E. coli may represent a perfect model organism for systems biology that is aimed at elucidating both its free-living and commensal life-styles, which should open the door to whole-cell modeling and simulation.
Dynamic Take Off - Accelerating Effects and the Feasibility of the Asian Expressway Network on China
KOHNO, Hirotada,HIGANO, Yoshiro,MATSUMURA, Yuji 한국지역사회개발학회 1994 地域社會開發硏究 Vol.19 No.2
We intend to construct a dynamic interregional input-output programming model in order to measure social economic effects of the Asian Expressway Network(AEN) on China and derive its investment criterion and do briefly feasibility study judging from the traffic volume derived. That is, the accelerating-system for carrying through the dynamic and interregional economic restructuring by adopting the opportunity cost principle such as 'competitive(domestic) import method' in the interregional substitutional selection of inputs is built into the model, by which the dynamic process of 'takeoff' of China will be derived. This model is not a mere dynamic multisector optimal growth model, but the one in which the computational algorithm for the simulation of traffic as signment on the network is built. By such a formulation, the demand for investment in every link in the transport route on the network of transport facilities can be, at length, derived endogenously and detailedly based on the opportunity cost principle. In Section 1, the characteristics of ultra-gigantic projects and the proposed AEN are described. In Section 2, the Characteristics of the measuring method adopted, i.e., economic effects-measuring model also are enumerated. Section 3 sets forth qualitatively the theoretical bases of dynamic multi-regions, cult-industries, multi-transport model facilities, programming model in order to measure the direct & indirect economic benefits and derive the takeoff-accelerating effects of the AEN on China, in which the inter regional input-output formulation slightly different from Moses model is developed, and the dynamical aspects constructed by both equations of 'demand-supply balance of the industrial capital' and 'capital formation' are explained. In Section 4, the only three basic data of partition of the China territory, industrial classification, and planning horizon are introduced corresponding to our specified concrete model of 12 regions, 5 periods, 9 industries, 5 transport facilities. Section 5 treats the premises, case setting for simulation analysis, and simulation results of optimum investment allocation by period to the links of the AEN are presented and analysed. in Section 5-4), the feasibility study is done based on the traffic volume derived, referring to the actual traffic results of the Japan Highway Public Corporation. In the final Section 6, the concluding comments as to the acceleration effect in taking off of the Chian economy brought about by the AEN are shown, and the optimum trajectories by simulation-case are analysed.
From the Sequence to Cell Modeling : Comprehensive Functional Genomics in Escherichia coli
Mori, Hirotada 한국생화학분자생물학회 2004 BMB Reports Vol.37 No.1
As a result of the enormous amount of information that has been collected with E. coli over the past half century (e.g. genome sequence, mutant phenotypes, metabolic and regulatory networks, etc.), we now have detailed knowledge about gene regulation, protein activity, several hundred enzyme reactions, metabolic pathways, macromolecular machines, and regulatory interactions for this model organism. However, understanding how all these processes interact to form a living cell will require further characterization, quantification, data integration, and mathematical modeling, systems biology. No organism can rival E. coli with respect to the amount of available basic information and experimental tractability for the technologies needed for this undertaking. A focused, systematic effort to understand the E. cofi cell will accelerate the development of new post-genomic technologies, including both experimental and computational tools. It will also lead to new technologies that will be applicable to other organisms, from microbes to plants, animals, and humans. E. coli is not only the best studied free-living model organism, but is also an extensively used microbe for industrial applications, especially for the production of small molecules of interest. It is an excellent representative of Gram-negative commensal bacteria. E. cofi may represent a perfect model organism for systems biology that is aimed at elucidating both its free-living and commensal life-styles, which should open the door to whole-cell modeling and simulation.
( Kazuhiko Nakamura ),( Eikichi Ihara ),( Hirotada Akiho ),( Kazuya Akahoshi ),( Naohiko Harada ),( Toshiaki Ochiai ),( Norimoto Nakamura ),( Haruei Ogino ),( Tsutomu Iwasa ),( Akira Aso ),( Yoichiro 대한소화기학회 2016 Gut and Liver Vol.10 No.6
Background/Aims: The ability of endoscopic submucosal dissection (ESD) to resect large early gastric cancers (EGCs) results in the need to treat large artificial gastric ulcers. This study assessed whether the combination therapy of rebamipide plus a proton pump inhibitor (PPI) offered benefits over PPI monotherapy. Methods: In this prospective, randomized, multicenter, open-label, and comparative study, patients who had undergone ESD for EGC or gastric adenoma were randomized into groups receiving either rabeprazole monotherapy (10 mg/day, n=64) or a combination of rabeprazole plus rebamipide (300 mg/day, n=66). The Scar stage (S stage) ratio after treatment was compared, and factors independently associated with ulcer healing were identified by using multivariate analyses. Results: The S stage rates at 4 and 8 weeks were similar in the two groups, even in the subgroups of patients with large amounts of tissue resected and regardless of CYP2C19 genotype. Independent factors for ulcer healing were circumferential location of the tumor and resected tissue size; the type of treatment did not affect ulcer healing. Conclusions: Combination therapy with rebamipide and PPI had limited benefits compared with PPI monotherapy in the treatment of post-ESD gastric ulcer (UMIN Clinical Trials Registry, UMIN000007435). (Gut Liver 2016;10:917-924)