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Robust Syntactic Annotation of Corpora and Memory-Based Parsing
( Erhard W Hinrichs ) 한국언어정보학회 2002 국제 워크샵 Vol.2002 No.-
This talk provides an overview of current work in my research group on the syntactic annotation of the Tiibingen corpus of spoken German and of the German Reference Corpus (Deutsches Referenzkorpus: DEREKO) of written texts. Morpho-syntactic and syntactic annotation as well as annotation of function-argument structure for these corpora is performed automatically by a hybrid architecture that combines robust symbolic parsing with finite-state methods ("chunk parsing" in the sense Abney) with memory-based parsing (in the sense of Daelemans). The resulting robust annotations can be used by theoretical linguists, who are interested in large-scale, empirical data, and by computational linguists, who are in need of training material for a wide range of language technology applications. To aid retrieval of annotated trees from the treebank, a query tool VIQTORYA with a graphical user interface and a logic-based query language has been developed. VIQTORYA allows users to query the treebanks for linguistic structures at the word level, at the level of individual phrases, and at the clausal level.
The role of mutations in COL6A3 in isolated dystonia
Lohmann, K.,Schlicht, F.,Svetel, M.,Hinrichs, F.,Zittel, S.,Graf, J.,Lohnau, T.,Schmidt, A.,Mir, P.,Krause, P. Springer Science + Business Media 2016 Journal of neurology: Zeitschrift für Neurolo Vol.263 No.4
<P>Specific mutations in COL6A3 have recently been reported as the cause of isolated recessive dystonia, which is a rare movement disorder. In all patients, at least one mutation was located in Exons 41 and 42. In an attempt to replicate these findings, we assessed by direct sequencing the frequency of rare variants in Exons 41 and 42 of COL6A3 in 955 patients with isolated or combined dystonia or with another movement disorder with dystonic features. We identified nine heterozygous carriers of rare variants including five different missense mutations and an extremely rare synonymous variant. In these nine patients, we sequenced the remaining 41 coding exons of COL6A3 to test for a second mutation in the compound heterozygous state. In only one of them, a second rare variant was identified (Thr732Met + Pro3082Arg). Of note, this patient had been diagnosed with ParkinsonA ' s disease (with dystonic posturing) due to homozygous PINK1 mutations. The COL6A3 mutations clearly did not segregate with the disease in the four affected siblings of this family. Further, there was no indication for a disease-modifying effect of the COL6A3 mutations since disease severity or age at onset did not correlate with the number of COL6A3 mutated alleles in this family. In conjunction with the relatively high frequency of homozygous carriers of reported mutations in publically available databases, our data call a causal role for variants in COL6A3 in isolated dystonia into question.</P>
Classifying Semantic Relations in German Nominal Compounds using a Hybrid Annotation Scheme
( Daniil Sorokin ),( Corina Dima ),( Erhard Hinrichs ) 서울대학교 인지과학연구소 2015 Journal of Cognitive Science Vol.16 No.3
This paper reports on novel results for the automatic classification of semantic relations that hold between the constituents of nominal compounds in German. It utilizes a hybrid annotation scheme that models semantic relations using a combination of prepositional paraphrases and semantic properties. The machine learning (ML) experiments use the support vector machine (SVM) implementation in Weka for single-label prediction tasks and Weka SVMs in conjunction with the Mulan library for multi-label prediction.
Chung, Sun Ju,Kö,nig, Inke R.,Lohmann, Katja,Hinrichs, Frauke,Kim, Juyeon,Ryu, Ho-Sung,Lee, Hyo Jeong,Kim, Kiju,Lee, Jeong Hoon,Jung, Kee Wook,Kim, Mi Jung,Kim, Mi-Jung,Kim, Young Jin,Yun, Sung-Ch Elsevier 2019 Parkinsonism & related disorders Vol.61 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Alpha-synuclein (α-Syn) immunostaining in the enteric nervous system (ENS) has been investigated to determine the role of diagnostic biomarker of Parkinson's disease (PD). However, determining factors for alpha-synuclein (α-Syn) deposition in the ENS of humans are still unclear. We aimed to investigate a possible association between <I>SNCA</I> variants and the presence of α-Syn immunostaining in the ENS in patients with PD and healthy individuals.</P> <P><B>Methods</B></P> <P>The study subjects consisted of 38 patients with PD and 46 healthy individuals. α-Syn immunohistochemistry was performed for gastric and colonic mucosal tissues of patients with PD and controls. Mucosal biopsy tissues of the ENS were obtained using standard biopsy forceps by endoscopic gastroduodenoscopy or colonoscopy. Two variants within the <I>SNCA</I> gene (the single nucleotide polymorphism [SNP] rs11931074 and the microsatellite REP1) were genotyped.</P> <P><B>Results</B></P> <P>In patients with PD, the rs11931074 (G allele) was significantly associated with the presence of α-Syn immunostaining in the ENS (OR = 5.96, 95% CI = 1.70–20.97, <I>P</I> = 0.01). In an interaction analysis, SNP rs11931074–PD status interaction was significantly associated with positive α-Syn immunostaining in the ENS (OR = 7.33, 95% CI = 1.58–33.88, <I>P</I> = 0.01). Longer <I>SNCA</I> REP1 alleles were not associated with positive α-Syn immunostaining in the ENS.</P> <P><B>Conclusion</B></P> <P>This exploratory study demonstrated that α-Syn deposition in the ENS may be associated with <I>SNCA</I> variants in patients with PD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Determining factors for alpha-synuclein (α-Syn) deposition in the enteric nervous system (ENS) of humans are still unclear. </LI> <LI> <I>SNCA</I> rs11931074 (G allele) is associated with α-Syn immunostaining in the ENS in patients with Parkinson's disease (PD). </LI> <LI> α-Syn deposition in the ENS may be associated with <I>SNCA</I> variants in patients with PD. </LI> </UL> </P>