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Suzuki Hirofumi,Okino Tadashi,Yamamoto Yuji,Shibutani Hideo 한국광학기기산업협회 2006 光學世界 Vol.101 No.-
디지털카메라, 카메라폰, DVD 픽업 등의 수요가 증가하고 있고, 유리 성형 기술의 자동화가 진보하고 있기 때문에 유리 성형 프로세스의 동아시아 이전·전개가 진행되고 있다. 최근 동아시아에서도 단순한 축대칭비구면의 성형틀은 정밀가공이 가능해져, 더욱 부가가치가 높은 광학부품을 생산해내기 위해, 복잡형상 세라믹틀의 연삭가공기술의 개발이 반드시 필요하다. 그래서 본고에서는 마이크로 복잡형상 광학부품 성형틀의 초정밀 미세가공기술의 일부를 소개하겠다.
Oda, Akira,Katayose, Yu,Yabuuchi, Shinichi,Yamamoto, Kuniharu,Mizuma, Masamichi,Shirasou, Satoru,Onogawa, Toru,Ohtsuka, Hideo,Yoshida, Hiroshi,Hayashi, Hiroki,Rikiyama, Toshiki,Kim, Hyunjung,Choe, You Potamitis Press 2009 Anticancer research Vol.29 No.4
<P>Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. The Period2 gene is essential in controlling the circadian rhythm and plays an important role in tumor suppression. We examined whether the overexpression of the mouse Period2 gene (mPer2) in cultured tumor cells from human tissues inhibits cell growth, using the recombinant adenovirus vector AdmPer2. The overexpression of mPer2 in human pancreatic cancer cells (Panc1, Aspc1) reduced cellular proliferation and induced apoptotic cell death. Infection with AdmPer2 also inhibited cell-cycle progression, inducing arrest at the G(2)-M phase. Western blotting analyses confirmed that infection with AdmPer2 reduced Bcl-X(L), Cdc2 and cyclin B1 protein, whereas it increased Bax protein in Aspc1 cells. The overexpression of mPer2 suppressed Cdc2 kinase activity. Moreover, infection with AdmPer2 resulted in dose-dependent synergic cell killing effects with the anticancer agent cisplatin (CDDP) in human pancreatic cancer cells. This synergic effect might be related to the reduction of Bcl-X(L) induced by infection with AdmPer2. Our results suggest that the circadian gene Period2 may play an important role in suppression of cell proliferation in human cancer, and additionally Period2 gene expression level may influence the sensitivity to cisplatin depending on Bcl-X(L) expression level.</P>