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Diego Hernandez-Hernandez,Tam Larkin,Nawawi Chouw 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.4
This research addresses experimentally the relationship between the excitation frequency and both hoop and axial wall stresses in a water storage tank. A low-density polyethylene tank with six different aspect ratios (water level to tank radius) was tested using a shake table. A laminar box with sand represents a soil site to simulate Soil-Structure Interaction (SSI). Sine excitations with eight frequencies that cover the first free vibration frequency of the tank-water system were applied. Additionally, Ricker wavelet excitations of two different dominant frequencies were considered. The maximum stresses are compared with those using a nonlinear elastic spring-mass model. The results reveal that the coincidence between the excitation frequency and the free-vibration frequency of the soil-tank-water system increases the sloshing intensity and the rigid-like body motion of the system, amplifying the stress development considerably. The relationship between the excitation frequency and wall stresses is nonlinear and depends simultaneously on both sloshing and uplift. In most cases, the maximum stresses using the nonlinear elastic spring-mass model agree with those from the experiments.
Edgar Hernandez Sosa,Yulianis Martín Castejón,Alexander Batista Duharte,Deivys Portuondo,Vivian Tamayo,Humberto J. Morris Quevedo,Clara Esther Martínez Manrique 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Trichilia hirta (Family Meliaceae) is a tree traditionally used in the folk medicine of Cuba to treat asthma, cancer, and ulcers. The objective of this study was to determine the phytochemical composition of ethanol extracts obtained from leaves, roots, and stem bark and to evaluate the leukocyte-stimulating effect of T. hirta root extracts on BALB/c mice. The chemical composition of the extracts was determined by phytochemical screening. Saponins, tannins, flavonoids, and coumarins were detected in extracts of T. hirta. The leukocyte-stimulating effect was evaluated by oral application of ethanol extracts (81.8 and 976 mg/kg) in BALB/c mice for 7 days. The application of 976 mg of extract/kg increased the total leukocyte count up to 15–33%; this effect was significant for neutrophil counts compared with control animals (P<.05). In addition, a dose of 82 mg/kg significantly increased total leukocytes at day 4 of the study (P<.05). The results indicated that T. hirta extracts contain phytochemicals reported as immunostimulants. The administration of these extracts to BALB/c mice indicated that ethanol extract could exhibit leukocyte-stimulating properties and makes it a promising alternative for the development of an immunoprotective agent.
Tapia-Hernandez, Alejandro,Ponce-Silva, Mario,Olivares-Peregrino, Victor Hugo,Valdez-Resendiz, Jesus Elias,Hernandez-Gonzalez, Leobardo The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.4
The main contribution of this paper is the use of sensorless active diodes to generate the gate signals for a three-phase boost-rectifier with a self-powered control scheme. The sensorless operation is achieved making use of the gate control signals generated by the active diode schemes on each of the switching devices using a pulse width half-controlled boost rectifier modulation technique (PWM-HCBR). The proposed scheme synchronizes the gate control signals with a three phase voltage supply. Autonomous operation is obtained making use of the output DC bus to feed the control circuitry, the active diodes and the driver circuitry. The three-phase boost-rectifier is supplied by a three-phase permanent magnet electric generator powered by a solar concentrator dish with variable voltage and variable frequency conditions. Experimental results report an efficiency of up to 94.6% for 25 W and an input of 3.6 V peak per phase with 450.
Vitamin D and its effects on cardiovascular diseases: a comprehensive review
( Nonanzit Perez-hernandez ),( Gad Aptilon-duque ),( Maria Cristina Nostroza-hernandez ),( Gilberto Vargas-alarcon ),( Jose Manuel Rodriguez-perez ),( Ruben Blachman-braun ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.6
Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.
Alejandro Tapia-Hernandez,Mario Ponce-Silva,Victor Hugo Olivares-Peregrino,Jesus Elias Valdez-Resendiz,Leobardo Hernandez-Gonzalez 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.4
The main contribution of this paper is the use of sensorless active diodes to generate the gate signals for a three-phase boost-rectifier with a self-powered control scheme. The sensorless operation is achieved making use of the gate control signals generated by the active diode schemes on each of the switching devices using a pulse width half-controlled boost rectifier modulation technique (PWM-HCBR). The proposed scheme synchronizes the gate control signals with a three phase voltage supply. Autonomous operation is obtained making use of the output DC bus to feed the control circuitry, the active diodes and the driver circuitry. The three-phase boost-rectifier is supplied by a three-phase permanent magnet electric generator powered by a solar concentrator dish with variable voltage and variable frequency conditions. Experimental results report an efficiency of up to 94.6% for 25 W and an input of 3.6 V peak per phase with 450.
Hernandez Alejandro,Nuñez Jorge H.,Sallent Andrea,Gargallo-Margarit Albert,Gallardo-Calero Irene,Barro Victor 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.2
Background: Untreated osteonecrosis of the femoral head ultimately leads to secondary coxarthrosis. The aim of this study was to determinate if the core decompression of the femoral head combined with implantation of autologous bone marrow concentrate with tricalcium phosphate could be used to prevent radiographic progression of early stage osteonecrosis of the hip. We also sought to determine whether this treatment improved clinical outcomes and reduced the need for total hip arthroplasty. Methods: Eighteen hips were included in the present study. All of them underwent core decompression of the femoral head combined with implantation of autologous bone marrow concentrate with tricalcium phosphate between 2007 and 2012. The cell concentrate was obtained from the posterior iliac crest and processed and implanted during the same surgical procedure. Patient demographic data, clinical data including modified Harris hip score, and radiological data were collected preoperatively, postoperatively, and during the follow-up period. Also, survival endpoints were analyzed: time of femoral head collapse and need for total hip arthroplasty. Results: The mean age of patients was 37.8 years (standard deviation [SD], 9.31 years). The mean follow-up was 68.9 months (SD, 15.0 months). In most cases (70.6%), the etiology of the osteonecrosis of the femoral head was corticosteroid use; in the remaining cases, secondary to alcohol use. Core decompression of the femoral head combined with implantation of autologous bone marrow concentrate with tricalcium phosphate did not prevent progression to collapse (< 80% at 5 years) although modified Harris hip scores improved. Overall median survival with the total hip arthroplasty as endpoint was 23 months (95% confidence interval [CI], 14.9 to 31.1 months). Overall median survival time with any degree of collapse as endpoint was 7 months (95% CI, 2.0 to 12.0 months). Conclusions: The results obtained in this study suggest that core decompression combined with implantation of autologous bone marrow concentrate and tricalcium phosphate will not prevent radiographic progression of early stage osteonecrosis of the hip. These finding also suggest that the absence of indications for hip replacement alone is not an indicator of good response to the treatment, and it is important to note the radiological results.
A biomedically oriented automatically annotated Twitter COVID-19 dataset
Hernandez, Luis Alberto Robles,Callahan, Tiffany J.,Banda, Juan M. Korea Genome Organization 2021 Genomics & informatics Vol.19 No.3
The use of social media data, like Twitter, for biomedical research has been gradually increasing over the years. With the coronavirus disease 2019 (COVID-19) pandemic, researchers have turned to more non-traditional sources of clinical data to characterize the disease in near-real time, study the societal implications of interventions, as well as the sequelae that recovered COVID-19 cases present. However, manually curated social media datasets are difficult to come by due to the expensive costs of manual annotation and the efforts needed to identify the correct texts. When datasets are available, they are usually very small and their annotations don't generalize well over time or to larger sets of documents. As part of the 2021 Biomedical Linked Annotation Hackathon, we release our dataset of over 120 million automatically annotated tweets for biomedical research purposes. Incorporating best-practices, we identify tweets with potentially high clinical relevance. We evaluated our work by comparing several SpaCy-based annotation frameworks against a manually annotated gold-standard dataset. Selecting the best method to use for automatic annotation, we then annotated 120 million tweets and released them publicly for future downstream usage within the biomedical domain.
Experiments on granular flow in a hexagonal silo: a design that minimizes dynamic stresses
Hernandez-Cordero, Juan,Zenit, R.,Geffroy, E.,Mena, B.,Huilgol, R.R. The Korean Society of Rheology 2000 Korea-Australia rheology journal Vol.12 No.1
In this paper, an experimental study of the rheological behavior of granular flow in a new type of storage silo is presented. The main characteristic of the new design is a hexagonal shape chosen with the objective of minimizing the stresses applied to the stored grains, and to reduce grain damage during the filling and emptying processes. Measurements of stress distribution and flow patterns are shown for a variety of granular materials. Because of the design of the silo, the granular material adopts its natural rest angle at all times eliminating collisional stresses and impacts between grains. A homogeneous, low friction flow is naturally achieved which provides a controlled stress distribution throughout the silo during filling and emptying. Secondary dynamic stresses, which are responsible for wall failure in conventional silos of the vertical type, are completely eliminated. A comparison between the two geometries is presented with data obtained for these silos and a number of granular materials. The discharge pattern inhibits powder formation in the silo and the filling system virtually eliminates unwanted material packing. Finally, notwithstanding the rheological advantages of this new design, the hexagonal cells that constitute the silo have many other advantages, such as the possible use of solar energy to control the humidity inside them. The cell type design allows for versatile storage capabilities and the elevation above the ground provides unlimited transportation facilities during emptying.