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RISS 인기검색어
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- 저자 : Hengameh Abdi (검색결과 1 건)
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Fereidoun Azizi,Navid Saadat,Mir Alireza Takyar,Hengameh Abdi,Ladan Mehran,Atieh Amouzegar 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.6
Background: This study compared the degree of sustained control of hyperthyroidism in patients with toxic multinodular goiter(TMNG) treated with long-term methimazole (LT-MMI) or radioactive iodine (RAI). Methods: In this clinical trial, 130 untreated patients with TMNG were randomized to either LT-MMI or RAI treatment. Bothgroups were followed for 108 to 148 months, with median follow-up durations of 120 and 132 months in the LT-MMI and RAIgroups, respectively. Both groups of patients were followed every 1 to 3 months in the first year and every 6 months thereafter. Results: After excluding patients in whom the treatment modality was changed and those who were lost to follow-up, 53 patients inthe LT-MMI group and 54 in the RAI group completed the study. At the end of the study period, 50 (96%) and 25 (46%) patientswere euthyroid, and two (4%) and 25 (46%) were hypothyroid in LT-MMI and RAI groups, respectively. In the RAI group, four(8%) patients had subclinical hyperthyroidism. The mean time to euthyroidism was 4.3±1.3 months in LT-MMI patients and 16.3±15.0 months in RAI recipients (P<0.001). Patients treated with LT-MMI spent 95.8%±5.9% of the 12-year study period in a euthyroid state, whereas this proportion was 72.4%±14.8% in the RAI-treated patients (P<0.001). No major treatment-related adverseevents were observed in either group. Conclusion: In patients with TMNG, LT-MMI therapy is superior to RAI treatment, as shown by the earlier achievement of euthyroidism and the longer duration of sustained normal serum thyrotropin.
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