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Planck Cold Clumps in the <i>λ</i> Orionis Complex. II. Environmental Effects on Core Formation
Yi, Hee-Weon,Lee, Jeong-Eun,Liu, Tie,Kim, Kee-Tae,Choi, Minho,Eden, David,II, Neal J. Evans,Francesco, James Di,Fuller, Gary,Hirano, N.,Juvela, Mika,Kang, Sung-ju,Kim, Gwanjeong,M. Koch, Patrick,Lee, American Astronomical Society 2018 The Astrophysical journal, Supplement series Vol.236 No.2
<P>Based on the 850 mu m dust continuum data from SCUBA-2 at James Clerk Maxwell Telescope (JCMT), we compare overall properties of Planck Galactic Cold Clumps (PGCCs) in the lambda Orionis cloud to those of PGCCs in the Orion A and B clouds. The Orion A and B clouds are well-known active star-forming regions, while the A Orionis cloud has a different environment as a consequence of the interaction with a prominent OB association and a giant H-II region. PGCCs in the lambda Orionis cloud have higher dust temperatures (T-d = 16.13 +/- 0.15 K) and lower values of dust emissivity spectral index (beta = 1.65 +/- 0.02) than PGCCs in the Orion A (T-d = 13.79 +/- 0.21 K, beta = 2.07 +/- 0.03) and Orion B (T-d = 13.82 +/- 0.19 K, beta =1.96 +/- 0.02) clouds. We find 119 substructures within the 40 detected PGCCs and identify them as cores. Out of a total of 119 cores, 15 cores are discovered in the lambda Orionis cloud, while 74 and 30 cores are found in the Orion A and B clouds, respectively. The cores in the lambda Orionis cloud show much lower mean values of size R = 0.08 pc, column density N(H-2) (9.5 +/- 1.2) x 10(22)cm(-2) , number density n(H-2) - (2.9 +/- 0.4) x 10 5 CM -3 , and mass M-core = 1.0 +/- 0.3 M(circle dot)compared to the cores in the Orion A [R = 0.11 pc, N(H-2) = (2.3 +/- 0.3) x 10(23) cm(-2), n(H-2) = (3.8 +/- 0.5) x 10(5)cm(-3) , and M-core = 2.4 +/- 0.3 M-circle dot] and Orion B [R = 0.16 pc, N(H-2) (3.8 +/- 0.4) x 10(23) cm(-2), n(H-2) = (15.6 +/- 1.8) x 10(5) cm(-3) , and M-core = 2.7 +/- 0.3 M-circle dot] clouds. These core properties in the A Orionis cloud can be attributed to the photodissociation and external heating by the nearby H rr region, which may prevent the PGCCs from forming gravitationally bound structures and eventually disperse them. These results support the idea of negative stellar feedback on core formation.</P>
STAT3-RANTES autocrine signaling is essential for tamoxifen resistance in human breast cancer cells.
Yi, Eun Hee,Lee, Chang Seok,Lee, Jin-Ku,Lee, Young Ju,Shin, Min Kyung,Cho, Chung-Hyun,Kang, Keon Wook,Lee, Jung Weon,Han, Wonshik,Noh, Dong-Young,Kim, Yong-Nyun,Cho, Ik-Hyun,Ye, Sang-Kyu American Association for Cancer Research 2013 Molecular cancer research Vol.11 No.1
<P>The acquisition of tamoxifen resistance is a major therapeutic problem in breast cancer. We developed a tamoxifen-resistant MCF-7 (TRM-7) cell line to elucidate the molecular mechanisms and factors associated with acquisition of such resistance. We showed that phosphorylation of STAT3 at tyrosine 705 (Y705) and RANTES expression are increased in response to tamoxifen in human breast cancer cells. On the basis of these results, we hypothesize that upregulated STAT3 phosphorylation and RANTES may be correlated with the development of drug resistance. Here, we showed that STAT3 and RANTES contribute to the maintenance of drug resistance. STAT3 phosphorylation is constitutively retained via a RANTES autocrine loop, which in turn upregulates anti-apoptotic signals in TRM-7 cells. STAT3-RANTES autocrine signaling affected expression of anti-apoptotic BCL-2 family genes and prevented TRM-7 cells from undergoing programmed cell death by inhibiting PARP and caspase-9 cleavage. Subsequently, blockade of STAT3 and RANTES in TRM-7 cells resulted in reduction of anti-apoptotic signals, which was rescued by exogenous RANTES treatment; drug resistance was also restored. Taken together, our results suggested that STAT3-RANTES autocrine signaling is essential for maintenance of drug resistance and inhibition of programmed cell death. These mechanisms of STAT3-RANTES autocrine signaling suggest a novel strategy for management of patients with tamoxifen-resistant tumors.</P>
Massilia jejuensis sp. nov. and Naxibacter suwonensis sp. nov., isolated from air samples
Weon, Hang-Yeon,Yoo, Seung-Hee,Kim, Soo-Jin,Kim, Yi-Seul,Anandham, Rangasamy,Kwon, Soon-Wo Microbiology Society 2010 International journal of systematic and evolutiona Vol.60 No.8
<P>Two Gram-negative, motile, rod-shaped bacteria (strains 5317J-18<SUP>T</SUP> and 5414S-25<SUP>T</SUP>) were isolated from air samples collected in the Jeju Island and Suwon region of Korea, respectively. Phylogenetically, strain 5317J-18<SUP>T</SUP> was grouped with the genus <I>Massilia</I> with <I>Massilia brevitalea</I> byr23-80<SUP>T</SUP> as the closest relative (98.8 % sequence similarity). Strain 5414S-25<SUP>T</SUP> was affiliated with the genus <I>Naxibacter</I> with <I>Naxibacter haematophilus</I> CCUG 38318<SUP>T</SUP> as the closest relative (98.8 % sequence similarity). The mean DNA-DNA relatedness values between strain 5317J-18<SUP>T</SUP> and <I>M. brevitalea</I> DSM 18925<SUP>T</SUP> and <I>Massilia aurea</I> DSM 18055<SUP>T</SUP> were 43 and 36 %, respectively. The mean DNA-DNA hybridization values between strain 5414S-25<SUP>T</SUP> and <I>N. haematophilus</I> KACC 13771<SUP>T</SUP>, <I>M. brevitalea</I> DSM 18925<SUP>T</SUP>, <I>Massilia timonae</I> DSM 16850<SUP>T</SUP>, <I>Naxibacter varians</I> KACC 13770<SUP>T</SUP>, <I>M. aurea</I> DSM 18055<SUP>T</SUP>, <I>Massilia lutea</I> DSM 17473<SUP>T</SUP> and <I>Massilia albidiflava</I> DSM 17472<SUP>T</SUP> ranged from 33 to 42 %. Both novel strains had ubiquinone Q-8 as the predominant isoprenoid quinone and summed feature 3 (comprising iso-C15 : 0 2-OH and/or C16 : 1<I>ω</I>7<I>c</I>) and C16 : 0 as the major fatty acids. Both strains also showed similar polar lipid profiles with phosphatidylethanolamine, phosphatidylglycerol and diphosphatidylglycerol as the major polar lipids. The DNA G+C contents of strains 5317J-18<SUP>T</SUP> and 5414S-25<SUP>T</SUP> were 66.1 and 67.8 %, respectively. On the basis of their phenotypic, chemotaxonomic and genotypic characteristics, the new strains represent novel species in the genera <I>Massilia</I> and <I>Naxibacter</I>. Strain 5317J-18<SUP>T</SUP> (=KACC 12634<SUP>T</SUP>=DSM 21309<SUP>T</SUP>) is proposed as the type strain of <I>Massilia jejuensis</I> sp. nov. and strain 5414S-25<SUP>T</SUP> (=KACC 12635<SUP>T</SUP>=DSM 21311<SUP>T</SUP>) is proposed as the type strain of <I>Naxibacter suwonensis</I> sp. nov.</P>