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Harrson S. Santana,João L. Silva Jr,Osvaldir P. Taranto 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-
Several studies have been carried out on biodiesel production in microreactors. Usually, in conventionalscale processes, researchers and industry professionals use modeling and simulation to develop andoptimize equipment and processes. However, modeling and simulation in microfluidics are still newwhen compared to conventional scale, being the literature even scarcer for biodiesel synthesis. In thiscontext, the biodiesel synthesis is discussed in this paper from the viewpoint of modeling andmicroreactors’ simulations. A state-of-art review emphasizing the design of microdevices is presented,followed by a discussion about modeling and simulation. Finally, the conclusions are exposed.
Droplet microfluidics for double lipase immobilisation using TiO2 and alginate microbeads
Rosilene Andrea Welter,Harrson Silva Santana,Bruna Gregatti Carvalho,Natalia Melani,Michael Oelgemöller,Lucimara Gaziola de la Torre,Osvaldir Pereira Taranto 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-
A double immobilisation technique was developed for C. antarctica lipase (CALB) that improved its enzymaticactivity and solved difficulties frequently observed in reactions catalysed by lipases. The firstimmobilisation consisted of CALB adsorption onto a TiO2 nanoparticle surface (CALB TiO2). The adsorptionwas carried out by an oriented monolayer formed by CALB’s hydrophilic amino acids and the TiO2 surface,leaving the CALB’s active site accessible for reaction. As a result, an increase in enzymatic activity wasachieved. The Relative Enzymatic Activity ((REA) obtained was 289%. The second immobilisation consistedof CALBTiO2 entrapment into calcium alginate microbeads [(CALBTiO2)EDTA-Ca], obtained by an internalcrosslinking ion-exchange mechanism and using microfluidic droplet technique. The microbiocatalystobtained, (CALBTiO2)EDTA-Ca, retained a high enzymatic activity (REAt=0 = 232%) and stability(REAt=30days = 263%) at a size (diameter, Ø=8.9104 nm) that enabled easier recovery than CALBTiO2(Ø = 2.3102 nm) or CALBFree (Ø=5.0 nm), and showed a favourable porosity for diffusion without releasingCALBTiO2. Although the microbeads showed CALBFree leaching, as demonstrated by the loss of REA after amechanical resistant test, (CALBTiO2)EDTA-Ca maintained an almost constant REA.
Renan Rodrigues de Oliveira Silva,Paulo Victor Cuesta Calvo,Christian Adrian Merfels,Mikael Vitor Rodrigues Lima,Harrson S. Santana,Attilio Converti,Mauri Sergio Alves Palma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Continuous flow synthesis in microreactors has been integrated into chemical-pharmaceutical industryin recent years as an alternative to the batch process due to its advantages, especially process intensification,which can reduce the time for a new drug to be placed on the market on a large scale. This workaimed to transpose the synthesis of Lobeglitazone, a drug employed in the treatment of diabetes mellitustype 2, from batch to flow process in a microreactor as well as to determine the reaction kinetics of eachstep. The synthesis was carried out in five-steps, being synthesized intermediates 4-chloro-6-(4-methoxyphenoxy)pyrimidine (I1), 2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethanol (I2), 4-(2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethoxy)benzaldehyde (I3), 5-[4-(2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethoxy)benzylidene]thiazolidine-2,4-dione (I4) andLobeglitazone. Intermediates I1 and I4 were synthesized in flow, while I4 was synthesized either in a continuousflow multistep synthesis or in a one-pot batch process. The flow syntheses of I1, I2 and I4 showed28.0 %, 61.8 % and 32.0 % yields at 25, 160 and 120 C, respectively, while the yield of I3 in batch processwas 73.3 % at 60 C. In one-pot batch process and continuous flow multistep synthesis, I2 was obtainedwith 13 and 16 % yields, respectively. These preliminary results constitute a starting point for the synthesisof this drug in flow on an industrial scale, with the aim of improving reaction performance using thisnew technology.