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        Opiate 수용체의 발달에 대한 연구

        홍은경,김해리 ( Eun Kyung Hong,Har Ret Kim ) 생화학분자생물학회 1984 BMB Reports Vol.17 No.4

        It was reported that the opiate peptides function as a neurotransmitter of neuromodulator. They may be involved in a natural pain suppression system (analgesia) or possibly also in other behavioral and emotional functions and food intake regulation. In the present study, the changes of opiate receptor binding in the whole brain, cortex, cerebellum, hypothalamus, midbrain, medulla oblongata, striatum, pylorus and ileum, from the 18th day of gestation to adulthood in both sexes were investigated. We observed that the developmental pattern of the opiate receptar binding is independent of both total protein content and protein concentration. The level of ³H-naloxone binding in brain regions, pylorus and ileum was divided into 3 groups according to the developmental pattern of ³H-naloxone binding. The cortex and midbrain belong to high binding group. The hypothalamus, striatum, and medulla oblongata belong to moderate binding group. ³H-Naloxone binding was low in the cerebellum, pylorus and ileum. Distinct differences between male and female rats were observable in the brain regions. The pattern of opiate receptor binding in the pylorus and ileum is more like that in the cerebellum than in any other brain regions.

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