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홍은경,김해리 ( Eun Kyung Hong,Har Ret Kim ) 생화학분자생물학회 1984 BMB Reports Vol.17 No.4
It was reported that the opiate peptides function as a neurotransmitter of neuromodulator. They may be involved in a natural pain suppression system (analgesia) or possibly also in other behavioral and emotional functions and food intake regulation. In the present study, the changes of opiate receptor binding in the whole brain, cortex, cerebellum, hypothalamus, midbrain, medulla oblongata, striatum, pylorus and ileum, from the 18th day of gestation to adulthood in both sexes were investigated. We observed that the developmental pattern of the opiate receptar binding is independent of both total protein content and protein concentration. The level of ³H-naloxone binding in brain regions, pylorus and ileum was divided into 3 groups according to the developmental pattern of ³H-naloxone binding. The cortex and midbrain belong to high binding group. The hypothalamus, striatum, and medulla oblongata belong to moderate binding group. ³H-Naloxone binding was low in the cerebellum, pylorus and ileum. Distinct differences between male and female rats were observable in the brain regions. The pattern of opiate receptor binding in the pylorus and ileum is more like that in the cerebellum than in any other brain regions.
두릅나무와 황백피의 혼합추출물 P55A 의 랫트 및 개에 대한 경구투여 급성독성
강부현(Boo Hyon Kang),손화영(Hwa Young Son),송시환(Si Whan Song),차신우(Shin Woo Cha),서동욱(Dong Oook Seo),이상봉(Sang Bong Lee),정영신(Young Sin Jung),홍은경(Eun Kyung Hong),김해리(Har Riet Kim),김성진(Sung Jin KIm) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.2
The current study was performed to determine the acute oral toxicity of P55A, a crude extract of 1:1 mixture of Phellodendron amurense cortex and Aralia elate cortex, in SD rats and beagle dogs. 5 rats of each sex were treated with a single dose of P55A orally at doses of 0 and 5,000 mg/kg respectively. Also 2 dogs of each sex were treated with a single dose of P55A orally at doses of 0 and 2,000 mg/kg, respectively. After the treatment, clinical signs, and body weight change were observed for 14 days. All rats survived during the study and did not show any clinical sign. Body weight gain showed no significant difference between the control and treated rats. Grossly, no lesion was observed in the rats. All dogs survived during the study. In clinical signs, dark stool was observed in the 2,000 mg/kg treated dogs at day 1 after administration. The animals recovered from general signs at day 2 after administration. Body weight gain showed no significant difference between the control and treated dogs. Grossly, no lesion was observed in the dogs. It is suggested that the LD_(50) of P55A by oral administration was estimated to be over 5,000 mg/kg in both sexes of rats and 2,000 mg/kg in both sexes of beagle dogs.