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- 저자 : Han Jo Kim1, Moo Jun Baek2, Dong Hyun Kang2, Sang- (검색결과 1 건)
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Association between c-Met and lymphangiogenic factors in patients with colorectal cancer
Han Jo Kim1, Moo Jun Baek2, Dong Hyun Kang2, Sang- 순천향대학교 일반대학원 2018 국내박사
Purpose: Animal models show a strong relationship between lymphangiogenesis and lymph node metastasis. however, the clinical significance of lymphangiogenesis in colorectal cancer (CRC) remains uncertain. The goal of this study was to evaluate the association between c-Met and lymphangiogenic factors and to elucidate the prognostic significance of c-Met in patients with CRC. Methods: A total of 379 tissue samples were obtained from surgically resected specimens from patients with CRC in Soonchunhyang University Cheonan Hospital between January 2002 and December 2010. The expressions of c-Met, vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, and podoplanin were examined by immunohistochemistry. The expression of c-Met and clinical factors were analyzed. Results: Three hundred and one of 379 (79.4%) tissues had c-Met expression. High expression of c-Met in tumor cells was significantly associated with high expression of VEGF-C (P 〈 0.001) and VEGFR-3 (P = 0.001). But, there was no statistically significant association with podoplanin (P = 0.587) and VEGF-D (P = 0.096). Of the 103 evaluable patients, expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = 0.020), positive lymph node status (P = 0.038), and high expression of VEGF-C (P = 0.020). But, there was no statistically significant association with podoplanin (P = 0.518), VEGFR-3 (P = 0.085), VEGF-D (P = 0.203), and overall survival (P = 0.360). Conclusion: Our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic markers. But, c-Met expression in patients with CRC are not prognostic indicator for overall survival.
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