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- 저자 : Han Guiying (검색결과 2 건)
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Li, Guiying,Han, Chang,Xu, Lihong,Lim, Kyu,Isse, Kumiko,Wu, Tong Wiley Subscription Services, Inc., A Wiley Company 2009 Hepatology Vol.50 No.3
<P><B>Abstract</B></P><P>Cyclooxygenase‐2 (COX‐2)–derived prostaglandins participate in a number of pathophysiological responses such as inflammation, carcinogenesis, and modulation of cell growth and survival. This study used complementary approaches of COX‐2 transgenic (Tg) and knockout (KO) mouse models to evaluate the mechanism of COX‐2 in Fas‐induced hepatocyte apoptosis and liver failure <I>in vivo</I>. We generated Tg mice with targeted expression of COX‐2 in the liver by using the albumin promoter‐enhancer–driven vector. The COX‐2 Tg, COX‐2 KO, and wild‐type mice were treated with the anti‐Fas antibody Jo2 (0.5 μg/g of body weight) for 4 to 6 hours, and the extent of liver injury was assessed by histopathology, serum aminotransferases, TUNEL staining, and caspase activation. The COX‐2 Tg mice showed resistance to Fas‐induced liver injury in comparison with the wild‐type mice; this was reflected by the lower alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, less liver damage, and less hepatocyte apoptosis (<I>P</I> < 0.01). In contrast, the COX‐2 KO mice showed significantly higher serum ALT and AST levels, more prominent hepatocyte apoptosis, and higher levels of caspase‐8, caspase‐9, and caspase‐3 activity than the wild‐type mice (<I>P</I> < 0.01). The COX‐2 Tg livers expressed higher levels of epidermal growth factor receptor (EGFR) than the wild‐type controls; the COX‐2 KO livers expressed the lowest levels of EGFR. Pretreatment with a COX‐2 inhibitor (NS‐398) or an EGFR inhibitor (AG1478) exacerbated Jo2‐mediated liver injury and hepatocyte apoptosis. <I>Conclusion:</I> These findings demonstrate that COX‐2 prevents Fas‐induced hepatocyte apoptosis and liver failure at least in part through up‐regulation of EGFR. (H<SMALL>EPATOLOGY</SMALL> 2009.)</P>
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Study on Selective Leakage Protection System of Mine Low-voltage Grid Based on Internet of Things
Liu Zhongfu,Han Guiying,Shi Lixin 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.7
Leakage is one of the most common fault forms of mine low-voltage grid protection. With the continuous increase of automation degree of mine, the leakage protection system of mine low-voltage grid needs to be monitored and managed comprehensively; as a response to this demand, the selective leakage protection system of mine low-voltage grid is explored and studied in this paper from the perspective of practical application based on Internet of Things. In this paper, the design of leakage protection system of mine low-voltage grid is proposed based on the combination of ZigBee protocol the framework of Internet of Things, and the perception layer of Internet of Things is constructed by ZigBee technology to collect and transmit the related data. Meanwhile, the low-voltage leakage fault principle of the mine and the variation law of zero-sequence current and zero-sequence voltage mine are analyzed in this paper; on this basis, a selective leakage protection scheme based on the additional DC power detection and zero-sequence power direction is proposed, in which additional DC power principle is applied to the main feeder switch, the protection principle of zero-sequence power direction is applied to the branch feeder switch, and the branch leakage is interpreted by Fourier algorithm. Through experimental verification, the performance indicators of leakage protection system are consistent with standard requirements, with the small error, which can meet the requirements of the mine grid leakage protection. Internet of Things can realize ZigBee networking and transmit the leakage information of the grid the host computer through ZigBee network.
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