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- 저자 : Hamilton Trinh (검색결과 2 건)
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Hamilton Trinh,Vicki Irish,Mireya Diaz,Humphrey Atiemo 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.3
Purpose: Intradetrusor onabotulinum toxin A (BTXA) and sacral neuromodulation (SNM) are effective third-line therapies for overactive bladder (OAB). We aimed to measure the outcomes of BTXA for treatment of OAB refractory to initial SNM and identify patient characteristics associated with these outcomes. Methods: This retrospective cohort study included patients who failed to respond to initial SNM treatment for OAB and subsequently received BTXA at a single provider’s clinic between January 2013 and December 2016. Treatment successes were defined as patients willing to continue BTXA or who found symptom relief whereas treatment failures discontinued BTXA due to adverse effects or lack of symptom relief. Symptoms and patient-reported outcomes on validated questionnaires were compared before the initial BTXA trial to 2 months after the last BTXA treatment. The SNM failure BTXA groups were also compared to BTXA SNM naïve groups. Results: Of 18 patients who received BTXA after failed SNM treatment, 7 (39%) achieved treatment success. Successfully treated patients demonstrated decreased urinary frequency from a median 11 voids/day pre-BTXA to 8 voids/day with BTXA (P=0.042). Patients whose treatment failed reported increased complaints of a weak urinary stream (P=0.03) and higher frequency of straining to urinate (P=0.016) than the successful treatment group pre-BTXA. Compared to BTXA patients without prior SNM, the odds of failing BTXA after initial SNM were 3.6 times higher (P=0.016). Conclusions: BTXA appears effective for OAB refractory to SNM, although the success rate is lower compared to BTXA patients without SNM exposure.
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Light-Induced Absorption and Holographic Recording in Pr:LiNbO3
Van-Thai Pham,임기수,D. S. Hamilton,Minh-Tuan Trinh,이선균 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.2I
With ultraviolet illumination, we have found a broad UV-induced absorption in the blue and some involvement of Pr ions in Pr:LiNbO3. Transient and stable absorption induced by UV illumination was analyzed at 457, 514, and 633 nm and could be explained by hole trap centers and iron ions. We also studied the effects of UV illumination and boundary conditions during holographic recording in the visible. In ultraviolet-gated short-circuit holographic recording, we obtained a high sensitivity and a high diffraction efficiency.
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