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Association of Insulin Resistance with Overactive Bladder in Female Patients
Hakki Uzum,Mehmet Kalkan,Adnan Yilmaz,Ahu Kemik,Orhan Unal Zorba 대한배뇨장애요실금학회 2012 International Neurourology Journal Vol.16 No.4
Purpose: Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder (OAB). Additionally, insulin resistance is the underlying mechanism of metabolic syndrome. We aimed to investigate the association of insulin resistance with overactive bladder in female patients. Methods: We prospectively conducted the study in our urology department. Female patients aged between 30 and 76 years old applied to our policlinics with or without OAB symptoms were enrolled. One hundred and twenty-two patients with OAB and 62 age-matched controls without OAB were included into the study. Fasting serum insulin, glucose, high-density lipoprotein (HDL-c), and triglycerides levels were measured. Insulin resistance value was obtained via the homeostasis model assessment of insulin resistance (HOMA-IR) calculator. The chi-square and Mann-Whitney U tests were used to compare differences in variables. Results: Serum insulin level was found higher in female patients with OAB (11.5±6.2 μU/mL) relative to controls (6.4±2.1 μU/mL), statistically significant (P=0.036). In addition, HOMA-IR was significantly found higher in the OAB group, 2.86 (0.76 to 17.04) in comparison to controls, 1.32 (0.67 to 224), P=0.018. High-density lipoprotein cholesterol levels (HDL-c) were significantly found lower in females with OAB. Conclusions: Insulin resistance can be associated to overactive bladder and may play significant role in pathogenesis.
Input Price Discrimination and Informative Advertisement Efforts
( Hakki Lee ) 한국산업조직학회 2020 産業組織硏究 Vol.28 No.3
This paper examines a monopolistic supplier’s optimal decision of input prices when two downstream sellers simultaneously choose their advertisement efforts and, then, output levels. In contrast to the previous literature, it demonstrates that allowing third-degree price discrimination leads the supplier to offer one seller (cost-efficient seller if they are asymmetric) a price discount and charge the other (inefficient seller) a higher fee to clarify the claim on the demand enhanced by informative advertisement and to avoid the under-advertisement problem. Therefore, it may increase aggregate output, consumer surplus, and social surplus- the reverse of the welfare implications in the previous literature.
Hakki Oktay Seymen,Sabiha Civelek,Arzu Seven,Gunnur Yigit,Husrev Hatemi,Gulden Burcak 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP
This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to cause an increase in thiobarbituric acid-reactive substances (TBARS) and copper zinc superoxide dismutase (Cu, Zn SOD) activity, but decreases in the glutathione-peroxidase (GSH Px) activity and glutathione (GSH). Iron supplementation caused an increase in TBARS and a decrease in GSH. Iron supplementation in hyperthyroid rats attenuated the hyperthyroid state, but lowered the plasma ferritin level, which is considered an indicator of thyroid hormone action. Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD. Our findings suggested no increase, but a decrease, in the risk of oxidative stress in iron supplemented hyperthyroid rats. Whether supplementation of iron would have similar effects in humans should be further investigated in clinical studies.
Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus
( Hakki Oguz Kazancioglu ),( Merve Erisen ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.5
Background: The treatment options for oral lichen planus (OLP) are numerous and include topical and systemic agents. Intralesional and systemic corticosteroids are used; however, the therapeutic results are often disappointing. Objective: To compare the influence of ozone, laser, and topical corticosteroid therapies in the treatment of OLP. Methods: One hundred twenty adult patients with ≤3 cm atrophic-erosive biopsy- proven OLPs in the tongue or buccal mucosa were recruited into the study. They were randomly assigned, by preoperative envelope drawing, to be treated with low-level laser therapy (LLLT group), ozone therapy (ozonated group), and topical corticosteroid therapy (positive control group). A placebo treatment containing base ointment without the active corticosteroid component was administered to patients in the negative control group. Response rate scores were determined on the basis of changes in the appearance score and pain score of the lesions between baseline and after each treatment. Results: The study subjects consisted of 56 male and 64 female OLP patients with a combined mean age of 42.6±8.3 years (range, 28∼55 years). No statistically significant difference was detected in clinical severity among the groups. The sign scores decreased in almost all scoring groups; however, statistically significant improvement was found in the ozonated and corticosteroid-treated groups. Symptom improvement was achieved after treatment with LLLT, ozone, and corticosteroid (p<0.05). The efficacy indices were significantly higher in the ozonated and corticosteroid- treated groups. Conclusion: Ozone and corticosteroid therapies were more effective than 808-nm LLLT in the treatment of OLP. (Ann Dermatol 27(5) 485∼491, 2015)
자동변속기 클러치 윤활 및 냉각해석을 통한 오일 홀 최적화
김학기(Hakki Kim),송경(Kyoung Song),박재인(Jaein Park),황동환(Dongwhan Hwang),김현석(Hyunsuk Kim) 한국자동차공학회 2011 한국자동차공학회 학술대회 및 전시회 Vol.2011 No.11
The flow rate of the automatic transmission fluid (ATF) from a input shaft to the clutch plates have been simulated as a three-dimensional and transient-state using the free surface method of commercial CFD code STAR-CCM+. During the disengagement of the wet clutch plates, amount of heat energy dissipated by the lubricating oil that flow the nominal gap between the plates which have relative rotating speed. To supply the oil equally into the nominal clearances among the friction plates, a lay out of the lubrication passage hole configuration is very important. Since the hole configurations can be changed by the hole number, shape and the position at the hub, the optimization of the oil hole configuration is necessary. It is difficult to estimate the flow rate of the lubricating oil exactly at each part of the automatic transmission because of its structural complexity under rotating conditions. This paper suggest the method that can estimate the optimal oil hole configurations which affect the temperature of the plates by using 1D ATF oil circuit simulation and the numerical thermal analysis program “clutchtherm” with the 3D CFD results. From this result, we can obtain various information about the lubricating state at every part of the plates and can help our judgment of whether lubrication is sufficient.
Training EFL/ESL teachers for a peaceful Asia-Pacific region
Ismail Hakki Mirici 서울대학교 교육연구소 2008 Asia Pacific Education Review Vol.9 No.3
In this experimental study which is based on qualitative and quantitative data collection from an experimental and a control group, it has been found that when some educational terms in English Language Teacher Training programs are strengthened in meaning through some adaptations to better convey the message, their effectiveness is increased. Therefore, it is suggested that foreign or second language teachers in the Asia-Pacific region should not teach the target language only for linguistic and communicative purposes but also to introduce characteristics of different cultures and to contribute to educating people who enjoy similarities, respect differences and value human rights.
Role of a Risk of Malignancy Index in Clinical Approaches to Adnexal Masses
Simsek, Hakki Sencer,Tokmak, Aytekin,Ozgu, Emre,Doganay, Melike,Danisman, Nuri,Erkaya, Salim,Gungor, Tayfun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18
Objective: The aim of this study was to evaluate predictive role of risk of malignancy index in discriminating between benign and malignant adnexal masses preoperatively. Methods: This retrospective study was conducted with a total of 569 patients with adnexal masses/ovarian cysts managed surgically at our clinic between January 2006 and January 2012. Obtained data from patient files were age, gravidity, parity, menopause status, ultrasound findings and CA125 levels. For all patients ultrasound scans were performed. For the assessment of risk of malignancy index (RMI) Jacobs' model was used. Histopathologic results of all patients were recorded postoperatively. Malignancy status of the surgically removed adnexal mass was the gold standard. Results: Of the total masses, 245 (43.1%) were malignant, 316 (55.5%) were benign and 8 (1.4%) were borderline. The mean age of benign cases was lower than malign cases ($35.2{\pm}10.9$ versus $50.8{\pm}13.4$, p<0.001). Four hundred and five of them (71.2%) were in premenopausal period. Malignant tumors were more frequent in postmenopausal women (81% versus 29%, p<0.001). All ultrasound parameters of RMI were statistically significantly favorable for malignant masses. In our study ROC curve analysis for RMI provided maximum Youden index at level of 163.85. When we based on cutoff level for RMI as 163.85 sensitivity, specificity, PPV, NPV was calculated 74.7%, 96.2%, 94% and 82.6%, respectively. Conclusions: RMI was found to be a significant marker in preoperative evaluation and management of patients with an adnexal mass, and was useful for referring patients to tertiary care centers. Although utilization of RMI provides increased diagnostic accuracy in preoperative evaluation of patient with an adnexal mass, new diagnostic tools with higher sensitivity and specificity are needed to discriminate ovarian cancer from benign masses.