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- 저자 : Haichuan Liu (검색결과 2 건)
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Inhibition of mouse SP2/0 myeloma cell growth by the B7-H4 protein vaccine
( Nan Mu ),( Nannan Liu ),( Qiang Hao ),( Yujin Xu ),( Jialin Li ),( Weina Li ),( Shouzhen Wu ),( Cun Zhang ),( Haichuan Su ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.7
B7-H4 is a member of B7 family of co-inhibitory molecules and B7-H4 protein is found to be overexpressed in many human cancers and which is usually associated with poor survival. In this study, we developed a therapeutic vaccine made from a fusion protein composed of a tetanus toxoid (TT) T-helper cell epitope and human B7-H4IgV domain (TT-rhB7-H4IgV). We investigated the anti-tumor effect of the TT-rhB7-H4IgV vaccine in BALB/c mice and SP2/0 myeloma growth was significantly suppressed in mice. The TT-rhB7-H4IgV vaccine induced high-titer specific antibodies in mice. Further, the antibodies induced by TT-rhB7-H4IgV vaccine were capable of depleting SP2/0 cells through complement-dependent cytotoxicity (CDC) in vitro. On the other hand, the poor cellular immune response was irrelevant to the therapeutic efficacy. These results indicate that the recombinant TT-rhB7-H4IgV vaccine might be a useful candidate of immunotherapy for the treatment of some tumors associated with abnormal expression of B7-H4. [BMB Reports 2014; 47(7): 399-404]
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Hussaini Abdullahi Umar,Xiaohui Zeng,Xuli Lan,Huasheng Zhu,Yirui Li,Haichuan Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.12
Filling layer self-compacting concrete (FLSCC) is an essential material used in the construction of China Rail Track System type III (CRTS III) slab track of high-speed rail. The mechanical properties of the filling layer are of paramount significance to the performance and serviceability of the track system. In this study, asphalt emulsion (AE) was incorporated into the FLSCC, and various properties related to workability, strength, durability, and damping performance were experimentally evaluated. The effect of AE on the durability of FLSCC was investigated through water absorption, sorptivity, and rapid chloride ion penetration tests; while damping properties were evaluated using impact resonance method. Results show that addition of AE decreases the compressive and split tensile strength while flexural strength increases, especially at lower AE content. The durability properties were greatly enhanced with the addition of AE, which results from the decreased permeability of FLSCC specimens due to the pore-filling effect of asphalt film that flows and fills the pores and cracks of the matrix. Damping ratio of FLSCC increased by 22.8%, 23.7%, 25%, and 30.6% through the addition of 5%, 10%, 15%, and 20% AE, respectively. According to the findings of this study, AE content up to 10% is recommended for FLSCC production.
ScienceON
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